Celiac Disease: An Overview and Personal
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1 Celiac Disease: An Overview and Personal Perspective By: Rie-ann Jansen BSN RN CGRN January 20, 2016 Celiac Disease an Overview and Personal Perspective OBJECTIVES: At the conclusion of this presentation, the participant will be able to: 1. Define celiac disease, its symptoms and associated disorders. 2. Explain the tests used to diagnose celiac disease. 3. Explain the treatment of celiac disease. 4. Identify the current legislative measures and research studies associated with celiac disease. 5. List three challenges associated with following the gluten free diet. Definition Symptoms Complications Associated Diseases/Syndromes Diagnosis Treatment Legislation Research/Clinical Trials 1
2 Celiac Disease: A Personal Perspective Diagnosis Challenges Shopping Food Preparation Eating Out Definition: an autoimmune genetic disease caused by an ingested trigger Autoimmune: ingestion of the trigger causes a response resulting in damage of small intestine Genetic: predisposition linked to HLA-DQ2 and HLA-DQ8 genes Ingested trigger: Proteins in wheat, barley, and rye 2
3 Facts and Figures Chance of developing CD Average healthy person 1 in 133 In people with related symptoms 1 in 56 People with 1 st degree relative 1 in 22 People with 2 nd degree relative 1 in 39 Facts and Figures CD affects at least 3 million Americans with 83% undiagnosed (1% of healthy, average Americans) Average length of time to diagnosis: 4 years No age barrier Usually involves a trigger Symptoms: More than 200 Common Abdominal pain/bloating Diarrhea/constipation Weight loss Pale, foul smelling, fatty stools Vomiting Uncommon Unexplained Fe-deficiency anemia Fatigue Bone/joint pain 3
4 Uncommon symptoms (cont.) Canker sores Dermatitis herpetiformis Silent/No Symptoms Long-term complications Anemia Osteoporosis Miscarriage/fertility issues Liver disease Intestinal cancers Rare Complications of Celiac Disease Refractory Sprue Ulcerative Colitis Lymphoma Associated Autoimmune Diseases IDDM Graves Disease Hashimoto s Thyroiditis Sjogrens Disease Associated Syndromes Down s Syndrome Turners Syndrome Williams Syndrome 4
5 Diagnosis All tests must be done with pt on normal diet Lab tests Tissue transglutaminase antibody (ttg), IgA Gliadin Antibody, IgA Total IgA EMA titer DGP Other possible tests: iron, folic acid, Ca+, Vitamins D, K, B Biopsy Done via upper endoscopy 6 biopsies from distal duodenum Normal small intestine 5
6 Normal Small Intestine and Histology Small Intestine: lack of villi, scalloping and celiac disease histology Treatment: COMPLETE and LIFELONG elimination of gluten from diet Gluten Gue free eede diet Avoidance of wheat, barley, rye, and oats* Obvious sources: bread, pasta, cereal, beer Hidden sources: NUMEROUS Canned, frozen, dry packaged items, precooked foods Non-food items: communion wafers, lipstick, play dough, meds, stamps, envelopes 6
7 Foods to Avoid Obvious wheat sources: flours, bran, gluten, starch, germ/oil Malts: flavoring, extract, milk, syrup, vinegar, beverages (beer/wine coolers) Barley: malt, extract Rye Mir, miso,matzo, graham flour, farina, couscous, cracker meal Bulgar: wheat, nuts Broth/Bouillons ** must be GF Cereals Hydrolyzed: oat starch, wheat gluten, wheat protein Gluten free Diet (cont.) Allowable foods Fresh meat, vegetables, fruits, and dairy products prepared with allowable ingredients Safe grains and starches Quinoa Nut flour Soy Millet Tapioca Potato Rice Bean Buckwheat Corn Amaranth Teff flour Certain canned, frozen, dried, packaged foods Cross Contamination Amount of gluten in the average diet: 10-40gm/day Smallest amount of gluten to cause damage: 0.1mg/day = 1/48 th slice of bread Amount of tolerable gluten: 1/8 th teaspoon of flour per day 7
8 1/19/2016 Education Dietary eayconsult Support Groups National Local Internet sites Improvement of symptoms Within days/weeks Healed Small Intestine 6-18 months (up to 2 years for adults Normalized Antibody Levels 3-12 months Follow up (controversial) 3-6 months after diagnosis 1 year after being on gluten free diet Annually Legislation The Food Allergen Labeling and Consumer Protective Act (FALCPA) Voluntary Definition of gluten free on product labels HR 3648: Gluten in Medicine Disclosure Act of 2015 Americans with Disabilities Act (504 Plan) Celiac disease is a disability USDA Child Nutrition Division School Lunch Guidelines 8
9 Clinical Trials Many studies in various stages throughout the world ALV003 (protease) Larazotide acetate Inoculation with Human Hookworm Published Study Increased Prevalence and Mortality in Undiagnosed Celiac Disease (Gastroenterology 2009; 137:88-93) Celiac Disease: A Personal Perspective Diagnosis Challenges Shopping/Cost ($$$) Food Preparation Eating out Celiac Disease: A Personal Perspective Shopping Loaf of bread $ $ hamburger buns $4.00-$7.00 Flour blend $5.00/pound Cold Cereal Varies Chocolate cake mix $3-$5/box Spaghetti (corn, rice) $2-$4/12 oz Quinoa elbow macaroni $2.50/8 oz. Xanthan gum $12.00/8oz 9
10 Celiac Disease: A Personal Perspective Shopping (continued) More traditional foods available General Mills Betty Crocker Better food labeling makes shopping easier Celiac Disease: A Personal Perspective Cooking/Baking Utensils: cross-contamination Recipes Flours/flour blends Commercial flour blends Homemade flour blends Individual flours Soy Flour Tapioca starch/flour Potato starch/flour Brown rice flour rice flour Xanthan gum Celiac Disease: A Personal Perspective Eating away from home Restaurants Potlucks Cafeterias High School College Hospital 10
11 Celiac Disease: A Personal Perspective Gluten Free Restaurant Dining Tips Be selective about type of restaurant t Prior contact with restaurant staff Avoid peak times Bring Plan B item Tell Server right away Articulate dietary restrictions Narrow your choices Ask questions Discuss possible hidden gluten Confirm order upon arrival to table Express appreciation Igel, Jeff Restaurant Survival for the Celiac: A Chef s Perspective Celiac Disease: A Personal Perspective Potlucks Ingredients of ingredients Plan on not being able to eat much Cross-contamination When in doubt, don t eat it Cafeterias High School College Hospital 11
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16 Celiac Disease: A Personal Perspective Conclusion Be knowledgeable about the disease Don t minimize the disease Ask patients their preferences/suggestions 16
17 and Personal Perspective The esilver Lining. RETURN OF VILLI Families living with Celiac Disease: happy and healthy 17
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23 Benedictine Sisters of Perpetual Adoration Thank You!! (NIH), N. I. (2013, September 11). Testing for Celiac Disease (For Healthcare Providers). Retrieved from topics/diagnostic-tests/testing-celiac-disease/pages/diagnostic-test.aspx Administration, U. F. (2015, June 15). Gluten-Free Labeling of Foods. Retrieved from lergens/ucm htm Awareness, N. F. (2015, November 1). Navigating the School System. Retrieved from Youth/Navigating-The-School-System/209/ Awareness, N. F. (2015, November 1). What is Celiac Disease? Retrieved from 5cf210a/what%20is%20celiac%20disease%20-% pdf Center, T. U. (2015). CDCFactSheets2_Symptoms. Retrieved from oms.pdf Center, T. U. (2015). Celiac Disease Facts and Figures. Retrieved from gures0614.pdf Center, T. U. (2016, January 15). Home / FAQs / What other autoimmune disorders are typically associated with those who have celiac disease? Retrieved from Cure Celiac: ClinicalTrials.gov. (n.d.). Retrieved from
24 Diseases, N. I. (2011, March). What I Need to Know About Celiac Disease. Retrieved from Igel, J. (. (2009, April 4). Restaurant Survival for the Celiac: A Chef's Perspective. Green Bay, WI. Kelly, C. P. (2015, June 18). Diagnosis of Celiac Disease in Adults. Retrieved from Pelkowski, T. D., & Viera, A. J. (January, ). American Family Physician. Retrieved from Celiac Disease: Diagnosis and Management: Sources of Gluten. (2016). Retrieved from Celiac Disease Foundation: gluten of gluten/ What Can I Eat. (2016). Retrieved from Celiac Disease Foundation: What I Need to Know About Celiac Disease. (n.d.). Retrieved from (Pathology slides photos obtained from private collection of Dr. Robert Cutlan, Green Bay, WI) 24
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