Cyanogenic Glycosides

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Cyanogenic Glycosides Cyanogenic glycosides are present in many plants and are converted to hydrogen cyanide or prussic acid when plant cells are damaged. The concentration of cyanogenic glycosides within a plant is variable: growth stage, moisture and time of day can all influence plant cyanogenic glycosides levels. Fertilization and herbicide application can increase cyanogenic glycoside concentrations. Chronic cyanide poisoning from eating sublethal doses over time causes loss of nerve function. Acute cyanide poisoning causes sudden death. Care should be taken to remove the plants containing cyanogenic glycosides from pastures. Common Pasture Plants Affecting the Nervous System Acroptilon repens Russian knapweed Apocynum cannabinum Hemp dogbane Centaurea solstitialis Yellow star thistle Cicuta douglasii Western water hemlock Conium maculatum Poison hemlock Daucus carota Wild carrot Delphinium spp. Larkspur Prunus spp. Black cherry & Chokecherry Trifolium spp. Clover Triglochin spp. Arrowgrass

Russian Knapweed, Acroptilon repens Identification: Creeping perennial with erect, branched stems from one to three feet. Young stems are softly pubescent. Lower leaves with toothed margins. Upper leaves with entire margins and stiff hairs. Lavender flowers in thistle-like heads with papery, spineless bracts. Whiteish seeds and papus remain in seed heads. Habitat: Cultivated fields, pastures and roadsides Animals Affected: Horses Toxin Family: Sesquiterpene lactones (neurotoxin) Other: Causes the formation of lesions and eventually affects horses ability to chew ( Chewing disease ). An increased tonicity of facial muscles causes horses to have a wooden expression. A lack of coordination of chewing muscles can cause frothy saliva, resembling rabies. Symptoms are very similar to yellow star thistle, but it appears Russian knapweed is more toxic, requiring a shorter feeding period to cause disease.

Hemp Dogbane, Apocynum cannabinum Identification: Perennial, growing up to six feet. Leaves opposite or whorled, oblong and entire. Stems often red and exude milky sap. Small white-ish flowers arranged in clusters at branch ends. Fruit is a long (3-8 inches), narrow pendulous pod, hanging in pairs, reddish-brown at maturity. Seeds have tufts of hair, similar to milkweed. Habitat: Roadsides, waste areas, open spaces and noncultivated agricultural lands; along streams and irrigation ditches Animals Affected: Especially horses Toxin family: Dogbane contains the glycosides apocynin and cymarin in the milky sap (resin), contained in all plant parts. Other: Can cause cyanogenic glycoside poisoning. Livestock are rarely poisoned by dogbane, and will eat it only when lacking other forages.

Yellow Star Thistle, Centaurea solstitalis Identification: Two- to Three-foot annual; flowers July-August. Rigid branching stems covered with cottony hairs. Lobed basal leaves. Stem leaves entire and covered with cottony hair. Yellow flowers; single at branch ends and with 3/4" thorny bracts. Germinates fall and spring. Habitat: Grasslands, rangelands, pasture, crop edges, roadsides and disturbed areas Animals Affected: Horses Toxin Family: Neurotoxins Other: Horses get "Chewing Disease" (inability to chew). Plant is toxic when green and dried and horses will develop a preferential liking for the plant. Horses must eat large quantities for toxins take effect. The plant is not toxic to sheep or cattle, which can be used for control.

Western Water Hemlock, Cicuta douglasii Identification: Perennial up to 2 meters tall. Stems with purple blotches. Stems are hairless and hollow, with compartments near the base. Alternate compound leaves, leaflets with toothy margins. Flowers in white-greenish umbrella-shaped umbels Habitat: Shallow ponds, swamps and marshes, irrigation ditches. Animals Affected: Humans and all livestock, but primarily cattle Toxin Family: Cicutoxin (a neurotoxin) contained in all plant parts: leaves and stems highly toxic in spring, decreasing as plant matures. Root is especially toxic always. Other: Causes rapid onset of muscle tremors and convulsions. Death occurs within hours of consumption. One of the most poisonous plants in N. America; removal of Western water hemlock from pastures should be a priority. Plants are generally easily removed by pulling and should be burned. Plants should be removed before setting seed, as that is their primary reproductive tactic. Spraying can increase palatability before plant dies.

Poison Hemlock, Conium maculatum Identification: Three- to seven-foot biennial. Blooms early summer. Erect hollow branching stems, alternate leaves, pinnately dissected and fern-like. Flowers in compound, flat-top umbel. Enlarged taproot. Reproduces prolifically by seed. Habitat: Waste areas, roadways, ditches, pastures and edges of cultivated fields Animals Affected: Humans and all livestock Toxin Family: Piperdine alkaloids (neurotoxins); all plant parts are poisonous. Other: Causes repertory failure and paralysis, leading to coma and death. Can cause skeletal defects in calves if eaten in small amounts by pregnant cows. Strong odor prevents palatability unless no other forage available.

Wild Carrot, Daucus carota Identification: Two- to four-foot biennial. Remains a rosette the first year, and flowers the second. Stems are erect and hollow, with stiff hairs. Leaves are alternate, stalked near base and sessile above; twice-pinnately compound with short hairs. Tiny white flowers grow in flat-topped umbels. Strong carrot odor. Habitat: Roadsides, pastures, waste areas Animals Affected: All livestock Toxin Family: Neurotoxin, photosensitization Other: Toxic only if large quantities are eaten. May be a skin irritant also. Graze infested areas only if abundant forage is available or late in the season and avoid grazing during the toxic window.

Larkspurs, Delphinium spp. Identification: At least 60 species exist in the West, from Alaska to Mexico. It is best to assume all are toxic. Generally, palmately-lobed leaves clustered around base. Hollow stems. Showy flowers, generally blue to purple with distinct, prominent spur; produced on terminal, erect racemes. Habitat: Pastures, rangeland Animals Affected: especially cattle, horses and sheep affected if consume vast quantities and are under stress. Toxin Family: Diterpenoid alkaloids Most toxic early in the season, and young leaves are palatable. Other: Tall larkspur becomes more palatable once stem elongates and flowers are produced (toxin is reduced later in the season, though seeds remain highly toxic). A toxic window occurs between stem elongation and seed set plants are palatable and still toxic. Low larkspurs are most palatable early in the spring, when they are most toxic. By the time low larkspur flowers, there is enough other forage to reduce cattle s interest. Poisoning leads to muscle weakness and paralysis. Rapid bloating in cattle, often they fall down with head pointed downhill. Death is rapid. Graze infested areas only if abundant forage is available or late in the season and avoid grazing during the toxic window. Larkspurs cause more fatalities of cattle in the western US than any other native plant.

Black Cherry & Chokecherry, Prunus spp. Prunus serotina Black cherry Identification: Woody shrub or small tree with gray bark and obvious horizontal lenticels. Leaves are dark green and shiny above, paler below and are finely serrated, oblong to lance-shaped, with very small inconspicuous glands on petiole. Leaves usually have a dense yellowish-brown, sometimes white pubescence along mid-rib. Small white flowers in drooping raceme. Edible dark purple to black fruits (seeds are toxic). Prunus virginiana Chokecherry Identification: Woody shrub or small tree with gray bark and obvious lenticels. Leaves ovate, finely toothed and rounded at the tip with glands on the petiole. Inflorescence is a cylindrical raceme of white, fragrant flowers. Edible dark purple to black fruits (seeds are toxic). Habitat: Forest edges, clearings, draws Animals Affected: Ruminants Toxin Family: Cyanogenic glycosides found in seed and leaves, bark and shoots. Other: Causes cyanide poisoning. Largest succulent leaves are most toxic. Wilted leaves and new growth are also highly toxic. Do not plant near animal enclosures.

Arrowgrass, Triglochin spp. Identification: Succulent, fleshy perennial grass-like plant. Long, linear basal leaves. Small inconspicuous greenish white flowers in a terminal pediceled raceme, appearing as an unbranched flower spike. Fruit a 3-6 celled golden pod that splits when mature. Habitat: Marshes, wet alkaline areas, native meadows, irrigated pasture Animals Affected: Primarily cattle and sheep Toxin Family: Cyanogenic glycosides Other: Symptoms include respiratory failure. All plant parts are toxic when green. Toxins are especially concentrated in the leaves under drought conditions and early spring. Fresh hay is toxic, but loses toxicity with increased storage. Highly palatable.