Magnitude of Residue Studies in Pesticide Registration Field Trials and Crop Grouping Johannes Corley, Daniel Kunkel, Jerry Baron IR-4 HQ, Rutgers the State University of New Jersey 500 College Rd. East # 201 W. Princeton, NJ 08540 jcorley@aesop.rutgers.edu http://www.ir4.rutgers.edu
Overview of Presentation Focus on Magnitude of Residue Studies Specialty crops and IR-4 Residue expression and analytes of concern Study set-up Location of field trials Transportation of samples, to cut or not to cut, that is the question Analytical phase Crop Grouping Collaboration throughout NAFTA Harmonization
Major Crops > 200,000 Acres Corn Cotton Rice horticultureintheord.files.wordpress.com www.commodityonline.com Soybean Wheat www.biggone.com img.breakingmuscle.com Etc.
Specialty Crops and IR-4 Cherry Sunflower Hops Ginseng Watercress Cranberry
Residue Expression & Analytes of Concern U.S. Residue Expression: Fenpyrazamine: Fenpyrazamine S-allyl 5-amino-2-isopropyl-4-(2- methylphenyl)-3-oxo-2,3-dihydropyrazole-1-carbothioate Zoxamide: Zoxamide and its metabolites 3,5-dichloro-1,4- benzenedicarboxylic acid and 3,5-dichloro-4-hydroxymethylbenzoic acid Propiconazole: Propiconazole 1-[[2-(2,4-dichlorophenyl)-4-propyl-1,3- dioxolan-2-yl] methyl]-1h-1,2,4-triazole and its metabolites determined as 2,4-dichlorobenzoic acid and expressed as parent compound
Study Setup and Planning Planning a Magnitude of Residue Study involves coordinating both field and analysis phases. All under US EPA Good Laboratory Practice Standards. Determining a use pattern (based on efficacy studies) Matching use patterns from different parts of the country Choosing a use pattern that would provide residue data in a worst case scenario Ensuring that the use pattern will not result in unfavorable residues or harm the crop or the environment
Crop Total # of trials Location of Field Trials EPA 860-1500 Guidelines Number of trials in each NAFTA region 1 2 3 4 5 6 7 8 9 10 11 12 13 Asparagus 8 1 2 3 2 Avocado 5 1 4 Carrot 8 1 1 1 4 1 Tomato 16 1 1 2 1 11
Conduct of a field trial - Application
Conduct of a field trial Sampling www.foodchannel.com
Analytical Phase
Crop Grouping 10-10. CITRUS FRUIT GROUP 10-10A. Orange subgroup 10-10B. Lemon/Lime subgroup 10-10C. Grapefruit subgroup Orange or tangerine/mandarin, lemon or lime, and grapefruit Orange or tangerine/mandarin Lemon or lime Grapefruit Australian desert lime; Australian finger-lime; Australian round lime; Brown River finger lime; calamondin; citron; citrus hybrids; grapefruit; Japanese summer grapefruit; kumquat; lemon; lime; Mediterranean mandarin; mount white lime; New Guinea wild lime; orange, sour; orange, sweet; pummelo; Russell River lime; satsuma mandarin; sweet lime; tachibana orange; Tahiti lime; tangelo; tangerine (mandarin); tangor; trifoliate orange; uniq fruit; cultivars, varieties, and/or hybrids of these Calamondin; citron; citrus hybrids; Mediterranean mandarin; orange, sour; orange, sweet; satsuma mandarin; tachibana orange; tangerine (mandarin); tangelo, tangor; trifoliate orange; cultivars, varieties, and/or hybrids of these Australian desert lime; Australian finger-lime; Australian round lime; brown river finger lime; kumquat; lemon; lime; mount white lime; New Guinea wild lime; Russell River lime; sweet lime; Tahiti lime; cultivars, varieties, and/or hybrids of these Grapefruit; Japanese summer grapefruit; pummelo; tangelo; uniq fruit; cultivars, varieties, and/or hybrids of these Source: IR-4 Website: www.ir4.rutgers.edu
Crop Grouping 8-10. FRUITING VEGETABLE GROUP Tomato, standard size, and one cultivar of small tomato; bell pepper and one cultivar of small non-bell pepper African eggplant; bush tomato; bell pepper; cocona; currant tomato; eggplant; garden huckleberry; goji berry; groundcherry; martynia; naranjilla; okra; pea eggplant; pepino; non-bell pepper; roselle; scarlet eggplant; sunberry; tomatillo; tomato; tree tomato; cultivars, varieties, and/or hybrids of these 8-10A. Tomato subgroup Tomato (standard size and one cultivar of small tomato) Bush tomato; cocona; currant tomato; garden huckleberry; goji berry; groundcherry; naranjilla; sunberry; tomatillo; tomato; tree tomato; cultivars, varieties, and/or hybrids of these 8-10B. Pepper/Eggplant subgroup Bell pepper and one cultivar of small non-bell pepper African eggplant; bell pepper; eggplant; martynia; non-bell pepper; okra; pea eggplant; pepino; roselle; scarlet eggplant; cultivars, varieties, and/or hybrids of these 8-10C. One cultivar of small non-bell pepper or Nonbell pepper/eggplant one cultivar of small eggplant subgroup Source: IR-4 Website: www.ir4.rutgers.edu and/or hybrids of these Source: IR-4 Website: www.ir4.rutgers.edu African eggplant; eggplant; martynia; non-bell pepper; okra; pea eggplant; pepino; roselle; scarlet eggplant ; cultivars, varieties,
NAFTA Harmonization, a Success Story
Harmonization of Regulatory Requirements Some important factors to be considered in simplifying global food trade: Harmonization of residue testing guidelines Harmonization of residue expressions Harmonization of trial requirements Using a standardized method to calculate MRL s Greater acceptance of Codex MRL s at least for import/export purposes
Acknowledgements Funding for IR-4 is received from: USDA-NIFA USDA-FAS Additional support for IR-4 research is received from: USDA-ARS U.S. State Land Grant Universities Unless otherwise stated, all pictures are from IR-4 trials and crop tours