Benchtop Evaluations of Tampering with Pharmaceutical Dosage Forms
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1 Benchtop Evaluations of Tampering with Pharmaceutical Dosage Forms Opioid Abuse Resistance Conference Philip A. Goliber, Ph.D. Andrew s Enterprises, LLC October 5 Tampering To interfere so as to weaken or change for the worse Manipulating a pharmaceutical dosage form so as to change its (drug delivery) performance in a way not specified or intended by the manufacturer Tampering is distinguished from abuse in that the latter can occur without manipulation of the dosage form 1
2 Scope of Tamper Evaluations Simulated IV Tampering Simulated Oral/Nasal Tampering Simple Extractions Advanced Extractions Simulated IV Tampering Three analysts (variability in crushing) Run intact or crush material via spoons or pill crusher Transfer to spoon Add 2 ml water - Mix with spatula heat to boiling - mix Draw into insulin syringe through cotton 2
3 Simulated IV Tampering EXTRACTION FOR INTRAVEUS USE Percent Released None Two Spoon Crushing Technique Pill Crusher Material Simulated IV Tampering GROUND INTACT Soluble / Extractable in small amounts (<=ml) water? Results in Injectable? Level 1 3
4 Simulated Oral/Nasal Tampering Simulated Oral/Nasal Chewing or crushing for nasal administration. (Mortar & Pestle 6,12,24 strokes) One strike on tablet to fracture, then count strokes Transfer using ml warm media ml of SGF w/pepsin for media Attempting to measure immediate release component Sampled after 5, 25 and 45 minutes Simulated Oral/Nasal Tampering CRUSHING FOR ORAL/NASAL USE Percent Released (5 min) Two Spoons Pill Crusher M&P 6x M&P 12x M&P 24x Material Crushing Technique 4
5 Simulated Oral/Nasal Tampering Soluble / Extractable with mild (M&P) grinding Results in active becoming immediately released Level 2 Simple Extractions Simple Extraction ml solvent 15 and 1 minutes. Water (RT) Water C Water 75C Water C Acid (.1N HCl; ph = 1.2) Base (2N NaOH; ph = 13.1) 5% Ethanol (beer) 14% Ethanol (wine) % Ethanol ( proof liquor) 5
6 Simple Extractions % Dissolved Extraction with Water for Oral/Nasal Use Water (RT) Water (C) Solvents Water (75C) Water (C) Simple Extractions Extraction with Ethanol for Oral/Nasal Use % Recovered Water (RT) EtOH (5%) EtOH (14%) EtOH (%) Solvents 6
7 Simple Extractions Soluble / Extractable under simple (water, ethanol ) conditions (e.g., ph, Temp) Results in active becoming immediately released Level 3 Advanced Extraction (Intact) (Intact) PERCENT EXTRACTED (15 min) Cooking Oil Baking Soda Vinegar Ethyl Acetate Ether Methanol % IPA Ethanol Acetone SOLVENT 7
8 Advanced Extraction (Crushed) (Crushed) PERCENT EXTRACTED (15 min) Ethanol Acetone Ether Methanol % IPA Cooking Oil Baking Soda Vinegar Ethyl Acetate SOLVENT Advanced Extractions Soluble / Extractable with advanced techniques (solvents / grinding) Results in ability to isolate the active ingredient Level 4 Level 5 8
9 Flow Chart for Dosage Form Tampering Level 1 Level 2 INTACT Soluble / Extractable in small amounts (<=ml) water? Results in Injectable? Soluble / Extractable with mild (M&P) grinding Results in active becoming immediately released GROUND Level 5 Results in ability to isolate the active ingredient Soluble / Extractable with advanced techniques (solvents / grinding) Results in active becoming immediately released Soluble / Extractable under simple (water, ethanol ) conditions (e.g., ph, Temp) Level 4 Level 3 Summary A consistent, logical scheme for evaluating the tamper resistance of pharmaceutical formulations Covers tamper methods from simple direct methods intended for IV use to more complex and longer processes Could form the basis for a set of standardized methods for general use 9
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