Fluopyram (AE C656948)

Transcription

1 FLUOPYRAM (24) The first draft was prepared by Mr David Lunn, Plants, Food & Environment Directorate, Ministry for Primary Industries, Wellington, New Zealand EXPLANATION, a pyridylethylamide broad spectrum fungicide was first evaluated by the 2 JMPR, where residue definitions were proposed, an ADI of. mg/kg bw and an ARfD of.5 mg/kg bw were established and maximum residue levels were recommended for a limited number of uses where GAP information was available. New GAP and supporting information were evaluated by the JMPR in 22 and in 2, with a number of additional maximum residue levels being recommended. The 2 JMPR also established residue definitions for fluopyram: For plant products (compliance with MRLs and dietary intake assessment) fluopyram For animal products (compliance with MRLs) sum of fluopyram and 2-(trifluoromethyl) benzamide, expressed as fluopyram For animal products (dietary intake assessment) sum of fluopyram, 2- (trifluoromethyl)benzamide and the combined residues N-{(E)-2-[-chloro-5- (trifluoromethyl)pyridin-2-yl]ethenyl}-2-trifluoromethyl) benzamide and N-{(Z)-2-[-chloro- 5-(trifluoromethyl)pyridin-2-yl]ethenyl}-2-trifluoromethyl) benzamide, all expressed as fluopyram. The 46 th Session of the CCPR (2) listed fluopyram for further evaluation by the 25 JMPR for additional MRLs and the current Meeting received new GAP information and/or new supporting residue information from the manufacturer for tomatoes, eggplants, beans, peas, soya beans (dry), sunflower seeds and cotton seed. The Meeting also considered relevant residue information provided to the JMPR in 2 for tomatoes, beans and peas (fresh and dry) and sunflower seeds. is N-{2-[-chloro-5-(trifluoromethyl)pyridin-2-yl]ethyl}-2- (trifluoromethyl)benzamide. It is relatively insoluble in water (5 mg/l), stable to hydrolysis, of low volatility (.2 6 Pa at 2 C), has a log P OW of. and is soluble (> 25 g/l) in methanol, dichloromethane, acetone, ethyl acetate and dimethyl sulfoxide. F C Cl O CF N N H (AE C656948) The following abbreviations are used for the metabolites discussed below. BZM -benzamide 2-(trifluoromethyl)benzamide E-olefine N-{(E)-2-[-chloro-5-(trifluoromethyl)pyridin-2-yl}-2-trifluoromethyl) benzamide Z-olefine N-{(Z)-2-[-chloro-5-(trifluoromethyl)pyridin-2-yl]ethenyl}-2-trifluoromethyl) benzamide

2 8 Methods of residue analysis Analytical methods The 2 JMPR reviewed and summarized analytical method descriptions and validation data for fluopyram and major metabolites (BZM, -OH, PCA, PAA and the methyl-sulfoxide) in crop and animal commodities, and in soil. These included Methods 984 and GM--P-, which were used to measure residues of fluopyram in the new supervised residue trials on tomatoes, beans and peas, soya beans, sunflower and cotton. In Method 984 and its minor variants, fluopyram residues were extracted by maceration with acetonitrile/water and residues were quantified by reversed-phase chromatography with tandem mass spectrometry (MS/MS) with electrospray ionisation. Method GM--P-, a modification Method 984, used an isotopically labelled internal standard and included an additional C- 8 solid phase extraction (SPE) clean-up step. USE PATTERNS Information on GAP in the USA and Canada, South Africa and a number of countries in Europe was provided to the Meeting for foliar applications or seed treatments to crops for which new or previously submitted data were available. This GAP information is summarized in Table. Table Registered uses of fluopyram, SC or FS formulations (including co-formulations with tebuconazole, trifloxystrobin and triadimenol) Crop Country Application Max/season PHI method kg ai/hl water no kg (days) max kg ai/ha (max) L/ha ai/ha Fruiting vegetables (except Cucurbits) Remarks: Eggplant (indoor) Greece spray d day RTI Peppers (indoor) Greece spray d day RTI Tomato Chile spray a day RTI Tomato (indoor) Greece spray d day RTI Tomato Morocco (22) spray b.25 2 day RTI Tomato Ukraine spray a.5. 2 Legume vegetables Beans Netherlands spray day RTI Beans Belgium spray day RTI from flowering (BBCH 6 9) Peas (without pods) Peas (without pods) Netherlands spray day RTI Belgium spray day RTI from flowering (BBCH

3 9 Crop Country Application Max/season PHI method kg ai/hl water no kg (days) max kg ai/ha (max) L/ha ai/ha Remarks: 6 9) Pulses Soya bean USA seed e.25 mg ai/seed.25 preplant No grazing or feed use Oilseeds Sunflower Moldovia spray c BBCH 2 5 Sunflower Ukraine spray c BBCH 2 5 Cotton seed USA seed e.5 mg ai/seed preplant Cotton seed USA infurrow spray RTI = Re-treatment interval (gr) preplant a SC formulation containing 2 g ai/l fluopyram + 2 g ai/l tebuconazole b SC formulation containing 25 g ai/l fluopyram + 25 g ai/l trifloxystrobin c SE formulation containing 25 g ai/l fluopyram + 25 g ai/l prothioconazole d SC formulation containing 25 g ai/l fluopyram + 25 g ai/l triadimenol e FS seed treatment formulation containing 6 g ai/l fluopyram Residues resulting from supervised trials The Meeting reviewed supervised field trial information provided to the JMPR in 2 and received new information on supervised field trials involving applications of fluopyram to the following crops. Crop Group Commodity Region Table No. Fruiting vegetables, other than cucurbits Tomato (protected) Tomato (outdoor) Europe Europe 2 Legume vegetables Beans (protected) Beans (outdoor) Europe Europe 4 a 5 a, 6 Peas Europe a, 8 Pulses Soya bean (dry) North America 9 a, Oilseeds Sunflower seed Europe Cottonseed North America 2, Legume animal feeds Bean forage Pea vines and hay Europe Europe a, 5 6 a, a Data from trials evaluated by the 2 JMPR The supervised trials were well documented with laboratory and field reports. Laboratory reports included method validation including procedural recoveries with spiking at residue levels

4 similar to those occurring in samples from the supervised trials. Dates of analyses or duration of residue sample storage were also provided. Although trials included control plots, no control data are recorded in the tables unless residues in control samples exceeded the LOQ. When multiple applications were made to a crop, the application rates, spray concentrations and spray volumes were not always identical from one application to the next. If the variation was small, only the final values for application rate, concentration and spray volume were recorded. For larger variations all values were recorded. Intervals of freezer storage between sampling and analysis were recorded for all trials and were covered by the conditions of the freezer storage stability studies reviewed by the 2 JMPR. Results from replicated field plots are presented as individual values and have not been corrected for concurrent method recoveries unless indicated. When residues were not detected they are shown as below the LOQ (e.g. <. mg/kg). Residues and application rates have been rounded to two significant digits (or if close to the LOQ, rounded to one significant digit). Average values have been calculated from the residue results prior to rounding, and the results from trials conducted according to the maximum GAP and used for the estimation of maximum residue levels have been underlined. In addition to the description and details of the field trials and analytical methods, each report includes a summary of the method validation, procedural recoveries, and in most cases, concurrent recoveries in stored frozen samples. In the trials, where multiple analyses are conducted on a single sample the average value is reported, and where duplicate samples have been analysed, both the individual results and the average values have been reported. Where results from separate plots with distinguishing characteristics such as different formulations, varieties or treatment schedules were reported, results are listed for each plot, and the highest value has been used in calculations of MRLs and STMRs. Fruiting vegetables (except Cucurbits) Tomatoes Results from supervised trials from Europe on greenhouse and field tomatoes were provided to the Meeting to supplement the data provided to the 2 JMPR. In four greenhouse trials provided to the Meeting, three applications of fluopyram (SC formulations) were made at day intervals to mature plants as foliar sprays using knapsack sprayers with hand lances ( 4 nozzles) to apply.5 kg ai/ha in 5 L water/ha. Plot sizes in these trials ranged from 5 46 m 2. In a further eight greenhouse trials, two applications of.5 kg ai/ha fluopyram in L water/ha were made at -day intervals using similar equipment and with plot sizes of 2 8 m 2. In eight field trials provided to the Meeting, two applications of fluopyram (SC formulations) were made at 6 day intervals to mature plants as foliar sprays using knapsack or motorised sprayers with 2 nozzle hand lances or mini-booms ( 9 flat-fan nozzles) to apply.5 kg ai/ha in 5 L water/ha. Plot sizes in these trials ranged from 2 8 m 2. In all trials, unreplicated samples of at least 2 kg or 24 fruit (48 for cherry tomatoes) were taken from each plot, frozen within 24 hours of sampling and stored at or below 8 C for up to 44 days before analysis for fluopyram and metabolites using LC/MS/MS Methods 984 or 984/M (LOQ. mg/kg). Mean recovery rates in samples spiked with.. mg/kg fluopyram ranged from 8 9%.

5 Table 2 Residues in tomatoes from supervised greenhouse trials in Europe involving two or three foliar applications of fluopyam (SC formulation) TOMATO Spain, 2 Sanlucar de Barrameda (Matias) Italy, 2 Croce Camerina (Parsifal) Germany, 2 Leichlingen (Albis) Netherlands, 2 Honselersdyk (Doloress) Germany, 2 Leichlingen (Meceno) Netherlands, 2 Zwaagdijk (Super Sweet ) Cherry tomato Belgium, 2 Saint-Amand (Macarena Beef tomato) France, 2 Castelsarrasin (Kiveli F Hybrid) Application Matrix DALA Residues.5. 5 fruit.5.2 fruit.5.5 fruit.5.5 fruit fruit fruit fruit fruit

6 2 TOMATO Spain, 2 Bigues i Riells (Plumcher) Cherry tomato Italy, 2 Vittoria (RG) (Creativo) Cherry tomato Greece, 2 Katerini, Pieria (Corbus) Cherry tomato Portugal, 2 Silveira-Torres Vedras (Bigran) Application Matrix DALA Residues fruit fruit fruit fruit

7 Table residues in tomatoes from supervised field trials in Europe involving two foliar applications of fluopyam (SC formulation) TOMATO France (S), 2 St Etienne du gres (Leader) Spain, 2 Los Palacios (Albatross) Italy, 2 Bologna (Monti) Portugal, 2 Almeirim (H-5) Greece, 2 Aronas, Katerini (Evia) RA--2, France (S), 2 Boé (Leader) Spain, 2 Alginet (Maplica) Italy, 2 Ostellato (548 f) Application Matrix DALA Residues fruit fruit fruit fruit fruit fruit fruit fruit <.... <. <. <

8 4 Legume vegetables Common beans Results from supervised trials from Europe on protected and outdoor common beans were provided to the Meeting to supplement the data provided to the 2 JMPR. In the 2 trials evaluated by the 2 JMPR, two applications of fluopyram (SC 5 formulations) were made 8 days apart as foliar sprays using knapsack or wheel barrow sprayers with 4 flat-fan, solid or hollow-cone nozzles or hand-held-booms ( 2 flat-fan nozzles), applying. kg ai/ha in 6-5 L water/ha to the protected crops and.25 kg ai/ha in L water/ha to the outdoor crops. Plot sizes in these trials ranged from 8 8 m 2. In the more recent trials, two foliar applications of.2 kg ai/ha fluopyram (SC formulations) were made 9 days apart using knapsack sprayers with flat-fan, solid or hollow-cone nozzles or plot boom sprayers (5 2 nozzles) to apply 5 L spray mix/ha to the protected crops and.25 kg ai/ha in L water/ha to the outdoor crops. Plot sizes in these trials ranged from 8 25 m 2. Unreplicated samples of kg of pods (including seeds) and in the outdoor trials at least 2 8 kidney bean plants (min kg green material, including pods and seeds) were taken from each plot, frozen within 24 hours of sampling and stored at 8 C or below for up to 456 days before analysis for fluopyram using LC/MS/MS Methods 984 or 984/M. The reported LOQs were. mg/kg for each analyte. Mean fluopyram recovery rates ranged from 8 98% in fresh pods spiked with. 4. mg/kg, 85 % in vines spiked with. mg/kg and % in seeds (fresh) spiked with.. mg/kg. Table 4 residues in protected common beans from supervised trials in Europe, evaluated by the 2 JMPR [Ref: JMPR 2 E, Table, pp ] BEANS Country, year (variety) France, 26 Rognonas (Nadal) France, 26 Noves (Donna) Spain, 26 Almerimar (Donna) Spain, 26 St M del Aguila (Festival) Application matrix DALA Residues & Comments no kg ai/ha kg ai/hl water 2.. pods 2.. pods pods pods RA-2596/6 9-6 RA-2596/ RA-2596/6 5-6 RA-2596/6 54-6

9 5 BEANS Country, year (variety) Germany, 26 Langenfeld (Markant) Germany, 26 Meckenbeuren (Eva) Netherlands, 26 Andijk (Overvloed) Belgium, 26 Villers-Perwin (Grappes de Malines) Spain, 2 Puebla de Vicar (Donna) Application matrix DALA Residues & Comments no kg ai/ha kg ai/hl water pods pods 2.. pods pods pods RA-2596/ RA-2596/ RA-2596/6 5-6 RA-2596/ RA-26/ 248-

10 6 Table 5 Residues in outdoor common beans from supervised trials in Europe, evaluated by the 2 JMPR [Ref: JMPR 2 E, Table 4, pp 56 ] BEANS Germany, 26 Lampertheim (Albani) Germany, 26 Langenfeld-Reusrath (Classic) Netherlands, 26 Zwaagdijk-Oost (Unknown) Belgium, 26 Villers-Perwin (Polder) Belgium, 2 Villers-Perwin (Cadillac) Germany, 2 Langenfeld-Reusrath (Classic) France, 2 Fresnoy les Roye (Lugos) Netherlands, 2 Biddinghuizen (Cadillac) Germany, 2 Swisttal-Heimerzheim (Sonesta) Application Matrix DALA Residues pods pods pods pods pods pods pods pods pods RA-2594/6-6 RA-2594/ RA-2594/ RA-2594/ RA-25/ - RA-25/ 546- RA-25/ 54- RA-25/ 548- RA-25/ 549-

11 BEANS Spain, 26 Alginet (Cleo) Italy, 26 Pradelle di Nogarole Rocca (Jamaica) Spain, 26 Malgrat de Mar (Nasao) Italy, 26 Ladispoli (Bronco) France, 2 Chazay d'azergues (Contender) Italy, 2 Ladispoli (Bronco) Spain, 2 Alginet (Cleo) Portugal, 2 Ribafria Peniche (Tradicional) Application Matrix DALA Residues pods pods pods pods pods pods pods pods RA-2595/6 8-6 RA-2595/ RA-2595/ RA-2595/ RA-252/ 5- RA-252/ 55- RA-252/ 55- RA-252/ 552- Table 6 residues in common beans from supervised outdoor trials in Europe involving two foliar applications of fluopyam (SC formulation) BEANS Application Matrix DAL A Residues

12 8 BEANS Germany, 22 Werl-Mawicke (Primel bean) France (N), 22 Fondettes (Contender) France (N), Picardie (Flavert) SC5 formulation A France (N), (Flavert) SC5 formulation B Italy, Lazio (Bronco) Kidney bean SC5 formulation A Italy, Lazio (Bronco) Kidney bean SC5 formulation B France (N), 2 Criquebeuf sur Seine (Flagrano) Application Matrix DAL A pods pods pods pods pods pods pods Residues < France (N), 2 Damery (Flagrano) seeds (green) pods 2.2 <. <. < Germany, 2 Heimerzheim (Orinoko) Belgium, 2 Villers-Perwin (Beaufort) seeds (green) pods pods 2.2 <. <. <. <. <. <. <. <. <

13 9 BEANS Spain, 2 Alginet (Cleo) Italy, 2 Ladispoli (Orinoko) France (S), 2 Toulouse (Argus) Portugal, 2 Ribafria (Bolinhas) France (S), 2 Toulouse-Croix daurade (Argus French bean) Spain, 2 Alginet (Cleo dwarf bean) Italy, 2 Andria (Blue lake) Portugal, 2 Atowia da Enreia (Bolinhas) Application Matrix DAL A pods pods pods pods pods pods pods pods 2 Residues < <..5 <. <. <. <. <.. < < Peas Results from supervised trials from Europe conducted in 22 on field peas were provided to the Meeting to supplement the data provided to the 2 JMPR. In the trials evaluated by the 2 JMPR, two applications of fluopyram (SC formulation) were made to peas 8 days apart as foliar sprays using knapsack or wheel barrow

14 5 sprayers with hand-held spray booms ( 2 flat-fan or hollow cone nozzles), applying.25 kg ai/ha in 6 L water/ha. Plot sizes in these trials ranged from 24 m 2. Unreplicated samples of at.5 4 kg succulent seeds, pods and/or whole plants (including pods and seeds but without roots) were taken from each plot, frozen within 24 hours of sampling and stored at 8 C or below for up to 29 days before analysis for fluopyram and its metabolites using LC/MS/MS Method 984. The reported LOQs were. mg/kg for each analyte and average fluopyram recovery rates were % in plants and pods spiked with. mg/kg and 88 99% in succulent seeds spiked with..5 mg/kg. In the 22 trials, two applications of fluopyram (SC formulations) were made to peas 9 days apart as foliar sprays using knapsack or plot sprayers with hand-held single-nozzle lances or spray booms ( 2 flat-fan or hollow cone nozzles), applying.2.25 kg ai/ha in 5 L water/ha. Plot sizes in these trials ranged from 45 6 m 2. Unreplicated samples of at least kg of fresh pods and vines (without pods and roots) and at least.5 kg of dry seeds and straw were taken from each plot, frozen within 24 hours of sampling and stored at 8 C or below for up to 46 days before analysis for fluopyram using LC/MS/MS Method 984 or 984/M. The reported LOQs were. mg/kg for each analyte and average fluopyram recovery rates ranged from 9 % in fresh pods spiked with. 2. mg/kg, 9 % in vines spiked with. 2 mg/kg, 8 % in seeds (fresh and dry) spiked with.. mg/kg and 89 98% in straw spiked with. 2 mg/kg. Table Residues in fresh peas (with and without pods) from supervised trials in Europe evaluated by the 2 JMPR. [Ref: JMPR 2 E, Table, pp 5 5] PEAS Germany, 26 Machern (Harnaß) United Kingdom, 26 Needham (Hawk) Germany, 26 Meckenbeuren (Rondo) Netherlands, 2 Kopstukken (unknown) Germany, 2 Burscheid (Wunder von Kelvedon) France, 2 Goyencourt (Arabelle) Belgium, 2 Landenne-Sur-Meuse (Tristar) Application Matrix DAL A pods seeds (green) pods seeds (green) pods seeds (green) seeds (green) seeds (green) seeds (green) seeds (green) Residues <. < RA-259/6 8-6 RA-259/ RA-259/6 2-6 RA-25/ 6- RA-25/ 55- RA-25/ 554- RA-25/ 555-

15 5 PEAS Germany, 2 Swisttal- Heimerzheim (Spring) Spain, 26 Brenes (Rondo) Italy, 26 Migliarino (Agami) France, 2 Chazay d'azergues (Douce de provence) Spain, 2 Brenes (Rondo) Application Matrix DAL A seeds (green) pods seeds (green) pods 9 seeds (green) seeds (green) seeds (green) Residues.2. < <. <. < RA-25/ 556- RA-2598/6 8-6 RA-2598/ RA-25/ - RA-25/ 55- Table 8 Residues in peas (with and without pods) from supervised field trials in Europe involving two applications of fluopyram (SC formulations) PEAS Spain, 22 Salobrena Granada (Utrillo) Application Matrix DALA Residues pods seeds (green) Spain, 22 Malaga (Utrillo) seeds (dry) pods seeds (green)... Italy, 22 Papiana Marsciano (Gran Rugoso Tondo) seeds (dry) pods seeds (green) seeds (dry) 2..62

16 52 PEAS Southern France, 22 Lapalud (Isard) Application Matrix DALA Residues pods seeds (green) <. <.. Spain, 22 Dos Hermanas (Cartouche) seeds (dry) pods seeds (green) Italy, 22 Ladispoli (RM) (Attika) seeds (dry) pods seeds (green) <. <..2 Greece, 22 Nea Messimvria (Li Violetta) seeds (dry) pods seeds (green).2.. Spain, 22 Alginet (Lincoln) seeds (dry) pods seeds (green) Germany, 22 Burscheid (Respect) seeds (dry) pods seeds (green) 2 <. <. <. <. seeds (dry) 9.

17 5 PEAS France (N), 22 Chaussy (Genial) Application Matrix DALA Residues pods seeds (green) 2..2 <..2 Germany, 22 Beucha-Wolfshain (Rocket) seeds (dry) pods seeds (green) Belgium, 22 Villers-Perwin (Ravenna) seeds (dry) pods seeds (green) <. <. <. United Kingdom, 22 Cambridge (Tommy) seeds (dry) pods 2 6 < (c=.) seeds (green) Germany, 22 Langförden (Alvesta) seeds (dry) pods seeds (green) <. <. <. Germany, 2 Burscheid (Mascara) seeds (dry) pods 22 2 < seeds (dry) 2.6.5

18 54 PEAS France (N), 2 Ambleville (Athos) Spain, 22 Salobrena (Utrillo) Application Matrix DALA Residues pods seeds (dry) pods mm rain mm rain within hour after 2 nd application seeds (green) Italy, 22 Zibido San Giacomo (Utrillo) seeds (dry) pods seeds (green) Spain, 2 Alginet (Lincoln) seeds (dry) pods seeds (green) Spain, 2 Dos Hermanas (Cartouche) seeds (dry) pods seeds (green) seeds (dry) 2. Pulses Soya bean (dry) Results from supervised trials from the USA on soya beans were provided to the Meeting. In these trials, fluopyram (SC formulation) was applied either as seed treatment to soya bean seeds, or as a seed treatment followed by two foliar applications to the plants. In the plots involving seed treatments, the seeds were slurry-treated with either.5 or.25 mg ai/seed and the targeted seeding rate was about 544, seeds/ha (equivalent to.82 kg ai/ha or.6 kg ai/ha respectively). Actual seeding rates ranged from 25, 642, seeds/ha. Plot sizes in these trials ranged from 46 m 2.

19 55 In the plots that also included foliar fluopyram treatments, one application of..2 kg ai/ha was made about 2 days before harvest with a second treatment of kg ai/ha applied 5 8 days later, using CO 2 plot or knapsack sprayers with hand-held spray booms or tractor-mounted boom sprayers to apply 9 9 L spray mix/ha. Duplicate samples of at least kg seeds were taken from each plot, frozen within 4 hours of sampling, held in frozen storage for up to 585 days before analysis for fluopyram using LC/MS/MS Method GM--P-, with a reported LOQ of. mg/kg and with an average fluopyram recovery rate of 9% in dry soya bean seeds spiked with..4 mg/kg. Table 9 residues in in soya beans (dry) from supervised trials in the USA involving seed treatment applications of fluopyram (SC formulations) SOYA BEAN Application Matrix DALA residues no. kg ai/ha mg ai/seed mean Seed treatment.5 mg ai fluopyram/seed USA, 22 Athens, GA (DP 4546 RR) USA, 22 Suffolk, VA (DP 4546 RR) USA, 22 Fisk, MO (Pioneer 9B52) USA, 22 Proctor, AR (Asgrow STB 444) USA, 22 Cheneyville, LA (AG44RR) USA, 22 Stewardson, IL (DP 564 RR) USA, 22 Marysville, OH (Garst 4RR) USA, 22 Northwood, ND (Agripro 22 RR/N) USA, 22 Seymour, IL (NKs G) USA, 22 Gardner, KS (S-4) USA, 22 Clarence, MO (RG 2) USA, 22 Sheridan, IN (Sucrosco 95- RNX.82.5 seeds, dry 5., <.. RAGMY6 GM-2HA.8.5 seeds, dry 8 <., <. <. RAGMY6 GM2-2HA.82.5 seeds, dry <., <. <. RAGMY6 GM-2HA.8.5 seeds, dry <., <. <. RAGMY6 GM4-2HA.8.5 seeds, dry seeds, dry , <. <., <..8,..26,.24.2,.2.9,.22.29,.2.2,..29,.26.2,.8 <.2 < RAGMY6 GM5-2DA RAGMY6 GM6-2DA.8.5 seeds, dry <., <. <. RAGMY6 GM-2HA.54.5 seeds, dry 6 <., <. <. RAGMY6 GM8-2HA.82.5 seeds, dry.,..2 RAGMY6 GM9-2HA.9.5 seeds, dry 6 <., <. <. RAGMY6 GM-2HA.82.5 seeds, dry 6 <., <. <. RAGMY6 GM-2HA.6.5 seeds, dry.8,.9.9 RAGMY6 GM2-2HA

20 56 SOYA BEAN USA, 22 Campbell, MN (NSQ49-Q9) USA, 22 Richland, IA (NK S49-Q9) USA, 22 Gardner, ND (DP 4546 RR) USA, 22 Geneva, MN (Hutchinson) USA, 26 Springfield, NE (RT25) USA, 22 Verona, WI (Pioneer 9M9) USA, 22 Stafford, KS (Pioneer 9B82) USA, 22 Delavan, WI (SC 984RR) USA, 22 Conklin, MI (9M9) Application Matrix DALA residues no. kg ai/ha mg ai/seed mean.9.5 seeds, dry 2 <., <. <. RAGMY6 GM-2HA.82.5 seeds, dry <.,.. RAGMY6 GM-2HA.85.5 seeds, dry 8 <., <. <. RAGMY6 GM5-2HB.8.5 seeds, dry <., <. <. RAGMY6 GM6-2HA.84.5 seeds, dry.2,.2.2 RAGMP9 GM-2HA.8.5 seeds, dry 6.2,.2.2 RAGMY6 GM8-2HA.8.5 seeds, dry 4.22,.2.2 RAGMY6 GM9-2HA.82.5 seeds, dry 6 <., <. <. RAGMY6 GM2-2HA.8.5 seeds, dry 6 <., <. <. RAGMY6 GM2-2HA Seed treatment.25 mg ai fluopyram/seed USA, 22 Athens, GA (DP 4546 RR) USA, 22 Suffolk, VA (DP 4546 RR) USA, 22 Fisk, MO (Pioneer 9B52) USA, 22 Proctor, AR (Asgrow STB 444) USA, 22 Cheneyville, LA (AG44RR) USA, 22 Stewardson, IL (DP 564 RR) USA, 22 Marysville, OH (Garst 4RR).6.25 seeds, dry 5.,.2.26 RAGMY6 GM-2HA.8.25 seeds, dry 8 <., <. <. RAGMY6 GM2-2HA.6.25 seeds, dry <., <. <. RAGMY6 GM-2HA.6.25 seeds, dry <., <. <. RAGMY6 GM4-2HA.6.25 seeds, dry seeds, dry , <. <., <..8,..26,.24.2,.2.9,.22.29,.2.2,..29,.26.2,.8 <.2 < RAGMY6 GM5-2DA RAGMY6 GM6-2DA seeds, dry <., <. <. RAGMY6 GM-2HA

21 5 SOYA BEAN USA, 22 Northwood, ND (Agripro 22 RR/N) USA, 22 Seymour, IL (NKs G) USA, 22 Gardner, KS (S-4) USA, 22 Clarence, MO (RG 2) USA, 22 Sheridan, IN (Sucrosco 95- RNX USA, 22 Campbell, MN (NSQ49-Q9) USA, 22 Richland, IA (NK S49-Q9) USA, 22 Gardner, ND (DP 4546 RR) USA, 22 Geneva, MN (Hutchinson) USA, 26 Springfield, NE (RT25) USA, 22 Verona, WI (Pioneer 9M9) USA, 22 Stafford, KS (Pioneer 9B82) USA, 22 Delavan, WI (SC 984RR) USA, 22 Conklin, MI (9M9) Application Matrix DALA residues no. kg ai/ha mg ai/seed mean.9.25 seeds, dry 6 <., <. <. RAGMY6 GM8-2HA.6.25 seeds, dry.,..2 RAGMY6 GM9-2HA..25 seeds, dry 6 <., <. <. RAGMY6 GM-2HA.6.25 seeds, dry 6 <., <. <. RAGMY6 GM-2HA.2.25 seeds, dry.8,.9.9 RAGMY6 GM2-2HA.6.25 seeds, dry 2 <., <. <. RAGMY6 GM-2HA.6.25 seeds, dry <.,.. RAGMY6 GM-2HA.2.25 seeds, dry 8 <., <. <. RAGMY6 GM5-2HB.4.25 seeds, dry <., <. <. RAGMY6 GM6-2HA..25 seeds, dry.2,.2.2 RAGMP9 GM-2HA..25 seeds, dry 6.2,.2.2 RAGMY6 GM8-2HA.6.25 seeds, dry 4.22,.2.2 RAGMY6 GM9-2HA.6.25 seeds, dry 6 <., <. <. RAGMY6 GM2-2HA.2.25 seeds, dry 6 <., <. <. RAGMY6 GM2-2HA Table residues in in soya beans (dry) from supervised trials in the USA involving seed treatment plus two foliar applications of fluopyram (SC formulations) SOYA BEAN Application Matrix DAL A no. kg ai/ha mg ai/seed (water/ha) Seed treatment.25 mg ai fluopyram/seed residues mean

22 58 SOYA BEAN USA, 22 Athens, GA (DP 4546 RR) USA, 22 Suffolk, VA (DP 4546 RR) USA, 22 Fisk, MO (Pioneer 9B52) USA, 22 Proctor, AR (Asgrow STB 444) USA, 22 Cheneyville, LA (AG44RR) USA, 22 Stewardson, IL (DP 564 RR) USA, 22 Marysville, OH (Garst 4RR) USA, 22 Northwood, ND (Agripro 22 RR/N) USA, 22 Seymour, IL (NKs G) USA, 22 Gardner, KS (S-4) USA, 22 Clarence, MO (RG 2) USA, 22 Sheridan, IN (Sucrosco 95- RNX no. kg ai/ha Application Matrix DAL A mg ai/seed (water/ha).25 (56) (62).25 () ().25 (8) (8).25 (6) (6).25 (6) (64).25 (9) ().25 (65) (64) (64) (64).25 (2) () () ().25 (94) (94) (9) (92).25 (2) (5).25 (5) (84).25 (9) (8) residues mean seeds, dry.2, RAGMY6 GM-2HA seeds, dry 24 <., <. <. RAGMY6 GM2-2HA seeds, dry <., <. <. RAGMY6 GM-2HA seeds, dry.6,..69 RAGMY6 GM4-2HA seeds, dry 5 2 seeds, dry 2.2,.8.25,..,.89.5,.98.92,.85.2,.8.49,.8.8,..9,.8., RAGMY6 GM5-2DA RAGMY6 GM6-2DA seeds, dry <., <. <. RAGMY6 GM-2HA seeds, dry <., <. <. seeds, dry <., <. <. RAGMY6 GM8-2HA seeds, dry., <.. seeds, dry RAGMY6 GM9-2HA seeds, dry <., <. <. seeds, dry 2.5,.5.5 RAGMY6 GM-2HA seeds, dry 2.5,..5 RAGMY6 GM-2HA seeds, dry., <.. RAGMY6 GM2-2HA

23 59 SOYA BEAN USA, 22 Campbell, MN (NSQ49-Q9) USA, 22 Richland, IA (NK S49-Q9) USA, 22 Gardner, ND (DP 4546 RR) USA, 22 Geneva, MN (Hutchinson) USA, 26 Springfield, NE (RT25) USA, 22 Verona, WI (Pioneer 9M9) USA, 22 Stafford, KS (Pioneer 9B82) USA, 22 Delavan, WI (SC 984RR) USA, 22 Conklin, MI (9M9) no. kg ai/ha Application Matrix DAL A mg ai/seed (water/ha).25 (8) (8).25 (6) ().25 (2) (4).25 (2) (8).25 () ().25 () ().25 () (2).25 () (2).25 (8) (9) residues mean seeds, dry.8,.6.8 RAGMY6 GM-2HA seeds, dry <., <. <. RAGMY6 GM-2HA seeds, dry.49,.5.5 RAGMY6 GM5-2HB seeds, dry.22,..26 RAGMY6 GM6-2HA seeds, dry 2.24,.2. RAGMP9 GM-2HA seeds, dry.22,.2.2 RAGMY6 GM8-2HA seeds, dry.242,.9.2 RAGMY6 GM9-2HA seeds, dry <.,..2 RAGMY6 GM2-2HA seeds, dry <., <. <. RAGMY6 GM2-2HA Oilseeds Sunflower seed Results from supervised trials from Europe on sunflowers were provided to the Meeting. In these trials, two applications of.. kg ai/ha (SC formulations) were made to sunflower plants, 5 days apart as foliar sprays using knapsack or CO 2 plot sprayers with hand-held or wheeled spray booms ( 2 nozzles) to apply 25 4 L spray mix/ha. Applications were made up to the seed development or early ripening stages (BBCH 6 85)Plot sizes in these trials ranged from 6 4 m 2. Unreplicated samples (min kg seed) were taken from each plot, frozen within 24 hours of sampling, held in frozen storage for up to 58 days before analysis of whole seeds. In a number of trials, seeds (min 9 kg samples) were also conditioned to < 8% moisture content, cleaned, crushed (between mm rubber rollers), shelled and dry-fractioned to separate the kernels (the commodity in trade), prior to analysis. The analytical methods used in these trials for measuring fluopyram residues were LC/MS/MS Method 948/M or 948/M, with a reported LOQ of. mg/kg and with average fluopyram recovery rates of 92 % in seeds, kernels and seed fractions spiked with.. mg/kg.

24 6 Table residues in sunflower seed (dried) from supervised trials in Europe, involving two foliar applications (SE formulations) SUNFLOWER SEED Study, Trial Germany, 2 Burscheid (Rigasol) Belgium, 2 Frasnes-Lez-Gosselies (LG 54.5 HO) Greece, 2 Gallikos, Kilkis (Sanay MP) Spain, 2 Fuentes de Andalucia (Transol) Germany, 2 Burscheid (Rigasol) Application Matrix DALA Residues no kg ai/ha kg ai/hl water seed < BBCH & seed 2 < BBCH 69 & seed BBCH & seed a BBCH & seed <. < BBCH 6 & Belgium, 2 Villers-Perwin (P64HE) kernel seed fraction seed <. <. <. <. <. <. < BBCH 65 & 69 Greece, 2 Kissa/Kozani (Sanay) kernel seed fraction seed <. < <. < BBCH 8 & 85 France (S), 2 Gargas (Tekny) kernel seed fraction seed <. <. <. <. <. <. < BBCH & 8 kernel seed fraction <. <. France (N), Mesnil Milon (Vellox Early variety) seed <. <., BBCH & 8 kernel seed fraction <. <.

25 6 SUNFLOWER SEED Study, Trial Belgium, Marbais (P64HE) Application Matrix DALA Residues no kg ai/ha kg ai/hl water seed <. <. <. <. < BBCH 6 & 8 kernel seed fraction <. <. France, 29 Tarascon (CSF 92) seed ,.65 < BBCH 9 & 8 kernel seed fraction <. <. Spain, 29 Dos Hermanas (PR64H) seed , BBCH 2 & 8 kernel seed fraction <. <. Italy, 29 Furbara Cerveteri (RM) (Starsol) seed , BBCH & 9 kernel seed fraction <. <. Portugal, 29 Aramanha-Várzea (PR64H4) seed BBCH 65 & kernel seed fraction <. <. Greece, 29 Kissa, Kozani (PR64LE2) seed <..5.6, BBCH 6 & 6 kernel seed fraction <. <. Italy, 29 Bologna (PR64H4) seed < BBCH 69 & 9 kernel seed fraction <. <. a Seeds stored for 6 days at 8 C before sampling

26 62 Cotton seed Results from supervised trials from the USA on cotton were provided to the Meeting. In these trials fluopyram was applied either as a pre-plant seed treatment, as a seed treatment in combination with an in-furrow soil treatment at planting or as a combination of a seed treatment, in-furrow soil treatment and a foliar spray applied about days before harvest. For the plots receiving treated seed, cotton seeds were slurry-treated with.5 mg ai/seed and the targeted seeding rate was about 8, seeds/ha (equivalent to.4 kg ai/ha). Actual seeding rates ranged from 4,495 8,65 seeds/ha. Residues in cotton seed and gin byproducts from the seed treatment plots and from plots involving the combination of seed treatment and infurrow soil treatments are summarized in the following tables. Plots were harvested by mechanical picker, mechanical stripper or manually, with duplicate samples of at least kg (undelinted seed plus gin trash) taken from the mechanically harvested plots and at least kg (seed cotton) from the manually harvested plots. Samples were frozen within 24 hours of sampling, ginned and held in frozen storage for up to 8 days before analysis for fluopyram using LC/MS/MS Method GM--P-, with a reported LOQ of. mg/kg and with average fluopyram recovery rates of 98% in undelinted seed spiked with.. mg/kg and 9% in gin by-products spiked with. 8 mg/kg. Table 2 residues in cotton seed and gin byproducts from supervised trials in the USA involving fluopyram seed treatment applications (.5 mg ai/seed (FS formulation) COTTON SEED USA, 22 Chula, GA (FM ) USA, 22 Parma, MO (ST45 LLB2) USA, 22 Proctor, AR (ST45) USA, 22 Greenville, MS, (ST 5458 (B2RF)) USA, 22 Claude, TX, (ST 45) USA, 22 Levelland, TX (ST5458 (B2RF)) USA, 22 Hinton, OK (FM B2RF) USA, 22 Wall, TX (FM B2RF) Application Matrix DALA residues no. kg ai/ha mg ai/seed mean.4.5 seed gin by-products..5 seed gin by-products.4.5 seed gin by-products 6 <., <..469,.29 8 <., <..,. 5 <., <..6,. <..54 <..24 <..5 RAGML26- GM22-2HA RAGML26- GM2-2HA RAGML26- GM24-2HA.4.5 seed 4 <., <. <. RAGML26- GM25-2HA.4.5 seed gin by-products.4.5 seed gin by-products <., <. <., <. <., <. <., <. <., <. <., <. <., <. <., <. <., <. <., <. 58 <., <. <., <. <. <. <. <. <. <. <. <. <. <. <. <. RAGML26- GM2-2HA RAGML26- GM-2HA.4.5 seed 2 <., <. <. RAGML26- GM29-2HA.2.5 seed 5 <., <. <. RAGML26- GM-2HA

27 6 COTTON SEED USA, 22 Sanger, CA (Acala) USA, 22 Madera, CA (Acala) USA, 22 East Bernard, TX (ST 5458 (B2RF)) Application Matrix DALA residues no. kg ai/ha mg ai/seed mean.2.5 seed <., <. <. RAGML26- GM-2HA.4.5 seed <., <. <. RAGML26- GM-2HA..5 seed gin by-products <., <..2,.2 <..2 RAGML26- GM-2HA Table residues in cotton seed and gin byproducts from supervised trials in the USA involving fluopyram seed treatments (FS formulation) in combination with in-furrow soil applications (SC formulations) COTTON SEED USA, 22 Chula, GA (FM ) USA, 22 Parma, MO (ST45 LLB2) USA, 22 Proctor, AR (ST45) USA, 22 Greenville, MS, (ST 5458 (B2RF)) USA, 22 Claude, TX, (ST 45) Application Matrix DALA residues no. kg ai/ha mg ai/seed mean seed gin by-products.5 seed gin by-products.5 seed gin by-products 6 <., <..64,.5 8 <., <..5,.2 5 <., <..8,.2 <..5 <.. <..2 RAGML26- GM22-2HA RAGML26- GM2-2HA RAGML26- GM24-2HA.5 seed 4 <., <. <. RAGML26- GM25-2HA.5 seed <., <. <., <. <., <. <., <. <., <. <. <. <. <. <. RAGML26- GM2-2HA USA, 22 Levelland, TX (ST5458 (B2RF)) USA, 22 Hinton, OK (FM B2RF) USA, 22 Wall, TX (FM B2RF) USA, 22 Sanger, CA (Acala) USA, 22 Madera, CA (Acala) gin by-products.5 seed gin by-products <., <. <., <. <., <. <., <. <., <. 58 <., <..,.5 <. <. <. <. <. <..6 RAGML26- GM-2HA.5 seed 2 <., <. <. RAGML26- GM29-2HA.5 seed 5 <., <. <. RAGML26- GM-2HA.5 seed <., <. <. RAGML26- GM-2HA.5 seed <., <. <. RAGML26- GM-2HA

28 64 COTTON SEED USA, 22 East Bernard, TX (ST 5458 (B2RF)) Application Matrix DALA residues no. kg ai/ha mg ai/seed mean seed gin by-products <., <..,. <.. RAGML26- GM-2HA Primary feed commodities Legume animal feeds Bean fodder and forage In the European outdoor field trials on beans evaluated by the Meeting, two applications of fluopyram (SC 5 formulations) were made 8 days apart as foliar sprays using knapsack or wheel barrow sprayers with 4 flat-fan, solid or hollow-cone nozzles or hand-held-booms ( 2 flat-fan nozzles), applying.25 kg ai/ha in L water/ha to plots ranging from 8 8 m 2. Unreplicated samples of kg of pods (including seeds) and at least 2 8 bean plants (min kg green material, including pods and seeds) were taken from each plot, frozen within 24 hours of sampling and stored at 8 C or below for up to 456 days before analysis for fluopyram using LC/MS/MS Methods 984 or 984/M. The reported LOQs were. mg/kg for each analyte. Mean fluopyram recovery rates ranged from 8 98% in fresh pods spiked with. 4. mg/kg, 85 % in vines spiked with. mg/kg and % in seeds (fresh) spiked with.. mg/kg. Table Residues in bean forage from supervised trials in Europe, evaluated by the 2 JMPR [Ref: JMPR 2 E, Table 4, pp 56 ] BEAN FORAGE Germany, 26 Lampertheim (Albani) Germany, 26 Langenfeld-Reusrath (Classic) Netherlands, 26 Zwaagdijk-Oost (Unknown) Belgium, 26 Villers-Perwin (Polder) Application Matrix DALA Residues vines vines vines vines RA-2594/6-6 RA-2594/ RA-2594/ RA-2594/

29 65 BEAN FORAGE Belgium, 2 Villers-Perwin (Cadillac) Germany, 2 Langenfeld-Reusrath (Classic) France, 2 Fresnoy les Roye (Lugos) Netherlands, 2 Biddinghuizen (Cadillac) Germany, 2 Swisttal-Heimerzheim (Sonesta) Spain, 26 Alginet (Cleo) Italy, 26 Pradelle di Nogarole Rocca (Jamaica) Spain, 26 Malgrat de Mar (Nasao) Italy, 26 Ladispoli (Bronco) Application Matrix DALA Residues vines vines vines vines vines vines vines vines vines RA-25/ - RA-25/ 546- RA-25/ 54- RA-25/ 548- RA-25/ 549- RA-2595/6 8-6 RA-2595/ RA-2595/ RA-2595/

30 66 BEAN FORAGE France, 2 Chazay d'azergues (Contender) Italy, 2 Ladispoli (Bronco) Spain, 2 Alginet (Cleo) Portugal, 2 Ribafria Peniche (Tradicional) Application Matrix DALA Residues vines vines vines vines RA-252/ 5- RA-252/ 55- RA-252/ 55- RA-252/ 552- Table 5 residues in bean forage from supervised outdoor trials in Europe involving two foliar applications of fluopyam (SC formulations) BEAN FORAGE Germany, 22 Werl-Mawicke (Primel bean) France (N), Picardie (Flavert) SC5 formulation A France (N), (Flavert) SC5 formulation B Italy, Lazio (Bronco) Kidney bean SC5 formulation A Application Matrix DALA Residues vines vines vines vines

31 6 BEAN FORAGE Italy, Lazio (Bronco) Kidney bean SC5 formulation B Germany, 2 Heimerzheim (Orinoko) Belgium, 2 Villers-Perwin (Beaufort) Application Matrix DALA Residues vines vines vines Pea vines and hay In the European trials on peas evaluated by the Meeting, two applications of fluopyram (SC formulation) were made to peas 9 days apart as foliar sprays using knapsack or wheel barrow sprayers with hand-held spray booms ( 2 flat-fan or hollow cone nozzles), applying.2.25 kg ai/ha in 6 L water/ha. Plot sizes in these trials ranged from 24 6 m 2. Unreplicated samples of at.5 4 kg whole plants (including pods and seeds but without roots), at least kg of fresh pods and vines (without pods and roots) and at least.5 kg of dry seeds and straw were taken from each plot, frozen within 24 hours of sampling and stored at 8 C or below for up to 46 days before analysis for fluopyram and metabolites using LC/MS/MS Method 984 or 984/M. The reported LOQs were. mg/kg for each analyte and average fluopyram recovery rates ranged from % in plants spiked with. mg/kg, 9 % in vines spiked with. 2 mg/kg, 8 % in seeds (fresh and dry) spiked with.. mg/kg and 89 98% in straw spiked with. 2 mg/kg. Table 6 Residues in fresh pea vines from supervised trials in Europe evaluated by the 2 JMPR [Ref: JMPR 2 E, Table, pp 5 5] PEA VINES Germany, 26 Machern (Harnaß) United Kingdom, 26 Needham (Hawk) Germany, 26 Meckenbeuren (Rondo) Application Matrix DAL A vines vines vines Residues RA-259/6 8-6 RA-259/ RA-259/6 2-6

32 68 PEA VINES Netherlands, 2 Kopstukken (unknown) Germany, 2 Burscheid (Wunder von Kelvedon) France, 2 Goyencourt (Arabelle) Belgium, 2 Landenne-Sur-Meuse (Tristar) Germany, 2 Swisttal- Heimerzheim (Spring) Spain, 26 Brenes (Rondo) Italy, 26 Migliarino (Agami) France, 2 Chazay d'azergues (Douce de provence) Spain, 2 Brenes (Rondo) Application Matrix DAL A vines vines vines vines vines vines vines vines vines Residues RA-25/ 6- RA-25/ 55- RA-25/ 554- RA-25/ 555- RA-25/ 556- RA-2598/6 8-6 RA-2598/ RA-25/ - RA-25/ 55-

33 69 Table Residues in pea vines and hay from supervised field trials in Europe involving two applications of fluopyram (SC formulations) PEA VINES/HAY Spain, 22 Salobrena Granada (Utrillo) Application Matrix DALA Residues vines Spain, 22 Malaga (Utrillo) straw vines Italy, 22 Papiana Marsciano (Gran Rugoso Tondo) straw vines Southern France, 22 Lapalud (Isard) straw vines Spain, 22 Dos Hermanas (Cartouche) straw vines Italy, 22 Ladispoli (RM) (Attika) straw vines Greece, 22 Nea Messimvria (Li Violetta) straw vines Spain, 22 Alginet (Lincoln) straw vines straw 2.64

34 PEA VINES/HAY Germany, 22 Burscheid (Respect) Application Matrix DALA Residues vines France (N), 22 Chaussy (Genial) straw vines Germany, 22 Beucha-Wolfshain (Rocket) straw vines Belgium, 22 Villers-Perwin (Ravenna) straw vines United Kingdom, 22 Cambridge (Tommy) straw vines Germany, 22 Langförden (Alvesta) straw vines (c=.) Spain, 22 Salobrena (Utrillo) straw vines (c=.29) Italy, 22 Zibido San Giacomo (Utrillo) straw vines 22 (c=.) straw 2.9.2

35 PEA VINES/HAY Spain, 2 Alginet (Lincoln) Application Matrix DALA Residues vines Spain, 2 Dos Hermanas (Cartouche) straw vines straw APPRAISAL, a pyridylethylamide broad spectrum fungicide was evaluated for the first time by the 2 JMPR, where an ADI of. mg/kg bw and an ARfD of.5 mg/kg bw were established, residue definitions were proposed and maximum residue levels were recommended for a number of uses where GAP information was available. New GAP and supporting information were evaluated by JMPR in 22 and 2 JMPRs and a number of additional maximum residue levels were recommended. Residue definitions established by the 2 JMPR are: for plant products (compliance with MRLs and dietary intake assessment): fluopyram for animal products (compliance with MRLs): sum of fluopyram and 2-(trifluoromethyl) benzamide, expressed as fluopyram for animal products (dietary intake assessment): sum of fluopyram, 2- (trifluoromethyl)benzamide and the combined residues N-{(E)-2-[-chloro-5- (trifluoromethyl)pyridin-2-yl]ethenyl}-2-trifluoromethyl) benzamide and N-{(Z)-2-[-chloro- 5-(trifluoromethyl)pyridin-2-yl]ethenyl}-2-trifluoromethyl) benzamide, all expressed as fluopyram. New GAP information and supporting residue data were provided by the manufacturer for evaluation by the Meeting. Results of supervised residue trials on crops The Meeting received new supervised trial data for foliar applications of fluopyram (SC formulations, generally in combinations with other fungicides) on tomatoes, beans, peas, and sunflower and for seed treatments or in-furrow soil treatments on soya bean and cotton. The Meeting also noted that data for some of these crops had been provided to the 2 JMPR. The results from these new trials and those previously reported by the 2 JMPR and either matching critical GAP or where the results can be proportionally adjusted (scaled) to reflect GAP application rates were used to estimate maximum residue levels, STMRs and HRs for a number of commodities for which GAP information was available. Frozen sample storage times in the new trials were within the storage intervals considered acceptable by the 2 JMPR and the analytical methods used in these trials were the same as those evaluated by JMPR in 2.

36 2 Fruiting vegetables (except Cucurbits) Tomato The Meeting was advised that new GAP exists in Greece for fluopyram on protected tomatoes, involving up to three foliar applications of.5 kg ai/ha with a -day PHI. In four independent protected tomato trials matching this GAP in Greece, residues were.4,.,.8 and. mg/kg. New GAP was also provided for tomatoes in Ukraine, up to two foliar applications of.5 kg ai/ha with a day PHI. In eight independent trials on field tomatoes conducted in Europe and matching this GAP in Ukraine, fluopyram residues were: <.,.2,.6,.,.,.,. and. mg/kg. The Meeting noted that the 2 JMPR had recommended a fluopyram maximum residue level of.4 mg/kg based on trials on protected tomatoes where residues had been proportionally adjusted to the GAP in Morocco. The Meeting agreed that the 2 JMPR recommendations accommodated the new GAPs for tomatoes in Greece and Ukraine. Peppers and eggplant The Meeting noted that the new GAP in Greece for fluopyram on protected tomatoes (.5 kg ai/ha, -day PHI) also applied to protected peppers and eggplants and that the 22 JMPR had recommended a maximum residue level of.5 mg/kg for peppers based on the GAP in Turkey. No trials matching the GAP in Greece on peppers and eggplants were available. The Meeting noted that the previous trials on protected peppers provided to the 2 and 22 JMPRs all involved only two applications and application rates of either.6 kg ai/ha or. kg ai/ha and agreed that the proportionality approach could not be used to support revised recommendations for peppers and/or extrapolation to eggplants. Legume vegetables Beans (except broad bean and soya bean) The critical GAP for beans in Netherlands and Belgium is for up to two foliar applications of.25 kg ai/ha, with a -day PHI and results from supervised trials from Europe on protected and outdoor beans were provided to the Meeting to supplement the data provided to the 2 JMPR. In nine independent trials on protected beans matching this critical GAP, fluopyram residues were:.,.5,.6,.6,.2,.22,.22,.4 and.69 mg/kg in beans with pods. In 2 independent trials on outdoor beans conducted in Europe and matching this critical GAP, fluopyram residues were: <., <.,.,.,.4,.4,.5,.5,.,.8,.8,.9,.,.,.,.,.2,.,.5,.,.,.,.8,.9,.2,.2,.24,.24,.25,.26,.2 and.4 mg/kg in beans with pods. (Results in bold are from the new trials). The Meeting noted that the data sets for protected and outdoor bean were statistically different and agreed to use the data from the trials on protected beans to estimate a maximum residue level of mg/kg, an STMR of.2 mg/kg and an HR of.69 mg/kg for fluopyram on beans (except broad bean and soya bean). Peas, shelled The critical GAP for peas (without pods) in Netherlands and Belgium is for up to two foliar applications of.25 kg ai/ha, with a -day PHI and results from supervised trials from Europe on outdoor peas were provided to the Meeting to supplement the data provided to the 2 JMPR.

37 In independent trials conducted in Europe and matching this critical GAP, fluopyram residues were: <., <., <., <.,.,.,.,.2,.2,.2,.2,.2,.2,.2,.,.,.,.,.4,.5,.5,.5,.5,.6,.6,.6,.9,.9,. and.2 mg/kg in peas without pods. (Results in bold are from the new trials). The Meeting estimated a maximum residue level of.2 mg/kg, an STMR of. mg/kg and an HR of.2 mg/kg for fluopyram on peas, shelled. Beans, shelled The Meeting noted that the GAP for beans in Netherlands and Belgium (up to two foliar applications of.25 kg ai/ha, with a -day PHI) was for beans with and without pods, and since this GAP for beans was the same as for peas, the Meeting agreed to extrapolate the data from peas, shelled to beans, shelled. The Meeting estimated a maximum residue level of.2 mg/kg, an STMR of. mg/kg and an HR of.2 mg/kg for fluopyram on beans, shelled. Soya bean (dry) Results from supervised trials from the USA on soya beans were provided to the Meeting. In 2 independent trials matching the GAP in the USA for use as a seed treatment (.25 mg ai/seed) fluopyram residues were <. (2),.,.,.,.2,.2,.,. and. mg/kg in dry soya beans. The Meeting noted that the metabolism studies did not cover the use of fluopyram as a seed treatment. However the Meeting noted the 2 JMPR conclusions that fluopyram is slowly degraded in soil and when present, is the major residue in -day PBI rotational crops and agreed that the established residue definitions would also cover the use of fluopyram as a seed treatment. The Meeting estimated a maximum residue level of.5 mg/kg and an STMR of. mg/kg for fluopyram on soya bean (dry). Oilseeds Sunflower seed Results from supervised trials from Europe on sunflowers were provided to the Meeting. The critical GAP in Ukraine and Moldovia is for up to two foliar sprays of.25 kg ai/ha, applied before the start of flowering (BBCH 5) and with a minimum PHI of 5 days. The Meeting received results from 2 independent trials conducted in Europe, where two foliar sprays of.25. kg fluopyram/ha were applied up to the seed development or early ripening stages (BBCH 6 85). As these trials did not match the critical GAP, the Meeting did not recommend a maximum residue level for fluopyram on sunflower seed. Cotton seed Results from supervised trials from the USA on cotton were provided to the Meeting. These trials included separate plots where fluopyram was applied as a pre-plant seed treatment, or as as a combination of a seed treatment and an in-furrow soil treatment at planting. In the USA, GAP exists for the use of fluopyram as a pre-plant seed treatment (.5 mg ai/seed) and also as an in-furrow soil treatment of.25 kg ai/ha. In the plots from independent trials where the seed was treated with.5 mg/kg/seed (.4 GAP), fluopyram residues in cotton seed were all <. mg/kg (n=) and in the plots treated with a seed treatment (.5 mg ai/seed.4 GAP) followed by an in-furrow soil treatment matching the US GAP (.25 kg ai/ha) residues in cotton seed were also <. mg/kg.