Contents of Furanocoumarins in Grapefruit Juice and Health Foods
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1 326 Vol. 49, No , Contents of Furanocoumarins in Grapefruit Juice and Health Foods Narue S6@6B6@> 1,,Mitsuo N6@6O6ID 2,Hiroko M6IHJBDID 1, Kayo H6<>CD 1,Keiko H>G6I6 1 and Hirofumi UH=>N6B6 1 1 Tama Branch Institute, Tokyo Metropolitan Institute of Public Health: Shibasaki-cho, Tachikawa, Tokyo , Japan; 2 Tokyo Metropolitan Institute of Public Health: Hyakunin-cho, Shinjuku-ku, Tokyo , Japan Interactions between grapefruit juice and medications have long been recognized. In recent years, several furanocoumarins (FCs) that inhibit P450 activity in intestinal microsomes have been isolated from grapefruit juice. FCs, i.e., bergamottin (BG), bergapten (BP), bergaptol (BT) and 6,7 -dihydroxybergamottin (DHB), in samples was extracted with acetonitrile, and separated on a Phenyl column using 0.1 phosphoric acid-acetonitrile gradient as a mobile phase, with monitoring at 311 nm. The recoveries of BG, BP, BT and DHB from lemon juice spiked at the level of 5.0 mg/g were , , and , respectively. The quantification limits were 1.0 mg/g in samples. The contents of BG, BP and DHB in grapefruit juice (n 13), citrus fruit of 20 species and health food (n 16) were measured. The contents of BG were 0 16 mg/g, 0 16 mg/g and mg/g, BT were 0 39 mg/g, 0 13 mg/g and 0 28 mg/g, DHB were 0 10 mg/g, 0 35 mg/g and mg/g, respectively. BP was not detected. These results suggest that patients prescribed calcium antagonists or antiallergic agents should be cautions about their intake of FCs from grapefruit juice, citrus and health foods. (Received January 28, 2008) Key words: furanocoumarins; bergamottin; 6,7-6,7 -dihydroxybergamottin; grapefruit juice; health food; citrus fruit; drug interaction; HPLC 1) 5) (BG) 6,7 - (DHB) (FC) 1) 3) P450 3A4 (CYP3A4) ) 3) 1 3 DHB t.html PIpdf 4 Vol. 59, p. 287, 2005
2 August DHB FC 6) 13) BG (BP) (BT) FC FC FC BG EXTRASYNTHESE S. A. BP EXTRASYNTHESE S. A. BT EXTRASYNTHESE S.A mg 50 ml DHB Ultrafine Chemicals 4.0 mg 20 ml 1mL BG, BP, BT DHB 200 mg FC FC 5mL 20 ml HPLC 3. Agilent Technologies 1100 series 4. HPLC CAPCELL PAK SG-Phenyl 5 mm, 4.6 mm i.d. 150 mm A B (A : B 50 : 50) 20 (80 : 20) 1.0 ml/min nm 20 ml 5. 1) 6) 10 g 30 ml ml 14, HPLC 2) 10 g HPLC 6. FC 0.2, 0.5, 1.0, 2.0, 5.0, 10.0, mg/ml FC 20 ml HPLC 1. HPLC FC HPLC UV 6) FC UV Fig nm nm 240 nm HPLC 311 nm 311 nm 6) BG DHB BT 3 HPLC 0.1 (4 : 6) BP BP BP DHB 1 Fig. 1. UV spectra of standard BG, DHB, BT and BP
3 328 Vol. 49, No. 4 Table 1. Contents of furanocoumarins in grapefruit juice and health foods Sample Analytical result (mg/g) BG DHB BT Fig. 2. HPLC chromatograms of BG, DHB, BT and BP in sample extracts (A) Standard: 1.0 mg/ml, (B-1) lemon juice: control, (B-2) lemon juice: furanocoumarins added (5.0 mg/g) Operating conditions: CAPCELL PAK SG-Phenyl (5 mm, 4.6 mm i.d. 150 mm) column, mobile phase (a) acetonitrile (b) 0.1 phosphoric acid, gradient elution a/b 50 : 50 (0 5 min) a/b 80 :20 (20 min), column temperature 40, flow rate 1.0 ml/min, detection wavelength UV 311 nm, injection volume 20 ml 0.1 (5 : 5) BG, BP, BT DHB 4 Fig. 2 HPLC mg/ml (r ) 1.0 mg/g 2. BT, DHB, BP BG 5.0 mg/g n 5 BT , DHB , BP , BG n 5 BT , DHB , BP , BG FC FC Table 1 FC BG 7.7 mg/g DHB 3.7 mg/ g BT 8.8 mg/g BP (a h) BG mg/g DHB 0 11 mg/g BT 0 12 mg/g 200 (i) BG 16 mg/g BG Grapefruit Juice a reconstituted fruit juice b reconstituted fruit juice ND c reconstituted fruit juice d reconstituted fruit juice ND e reconstituted fruit juice f reconstituted fruit juice 7.2 ND 6.8 g reconstituted fruit juice h reconstituted fruit juice 4.5 ND 12 i reconstituted fruit juice (200 ) 16 ND 26 j 30 fruit juice beverage ND ND 3.1 k mix fruit juice 4.8 ND 5.5 l straight fruit juice m straight fruit juice Health Food 1 jelly drink ND ND ND 2 jelly drink ND ND ND 3 jelly drink ND ND jelly drink ND ND ND 5 tablet tablet ND capsule ND ND ND 8 granule 5.6 ND 28 9 granule ND ND ND 10 granule ND ND ND 11 drink ND ND ND 12 drink ND ND ND 13 drink ND ND ND 14 candy ND 3.5 ND 15 jelly candy ND ND ND 16 biscuit ND ND ND ND: not detected : BPwas not detected. DHB 30 (j) BG DHB BT 3.1 mg/g 1 (k) BG 4.8 g/g, BT 5.5 mg/g DHB 2 (m) BG 7.4 mg/g, DHB 7.9 mg/g, BT 2.9mg/g (l) BG 32 g/g, DHB 2.0 mg/g, BT 39 mg/g BG 2 BT ), 14) FC FC 6) 7 BG DHB 100
4 August i k l 9 b BG f h 2 DHB 6 (a, c, d, e, g, m) BG DHB ml FC Table 2 FC BG mg, DHB mg, BT mg ml ) 100 a h l m ml FC mg 10 mg BG 5.6 mg/g 3 DHB 6.2 mg/g 4 BT 28 mg/g BP FC 7 1 FC Table ml 1/20 FC FC 4. FC 20 Table 3 DHB BG FC De Castro 10) Fukuda Table 2. Daily intakes of BG, DHB and BT in grapefruit juice and health foods Sample Furanocoumarins (mg/day) BG DHB BT Grapefruit juice a reconstituted fruit juice b reconstituted fruit juice ND c reconstituted fruit juice d reconstituted fruit juice ND e reconstituted fruit juice f reconstituted fruit juice 1.4 ND 1.4 g reconstituted fruit juice h reconstituted fruit juice 0.90 ND 2.4 i reconstituted fruit juice (200 ) 3.2 ND 5.2 j 30 fruit juice beverage ND ND 0.62 k mix fruit juice 0.96 ND 1.1 l straight fruit juice m straight fruit juice Health food (daily intake) 1 jelly drink (180 g) ND ND ND 2 jelly drink (180 g) ND ND ND 3 jelly drink (130 g) ND ND jelly drink (150 g) ND ND ND 5 tablet (4 g) tablet (38 g) ND capsule (2.1 g) ND ND ND 8 granule (4 g) ND granule (8 g) ND ND ND 10 granule (4 g) ND ND ND 11 drink (120 g) ND ND ND 12 drink, powder (12 g) ND ND ND 13 drink (150 g) ND ND ND 14 candy (30 g) ND 0.11 ND 15 jelly candy (31 g) ND ND ND 16 biscuit (80 g) ND ND ND ND: not detected : To estimate the daily intakes, it was assumed that a person takes 200 ml of grapefruit juice in a day. : Toestimate the daily intakes, it was assumed that a person takes one package or the recommended serving size per day as shown on a package. 14) FC FC Saita 15) 15 red pummelo 8 Saita 15) FC FC 200 ml 200 g FC
5 330 Vol. 49, No. 4 Table 3. Quantitative comparison of furanocoumarins in grapefruit and other citrus fruits No. of samples Analytical result (mg/g) BG DHB BT Grapefruit (white) 2 6.3, , 7.9 ND Grapefruit (ruby) 2 4.1, 4.9 ND ND Grapefruit (white), Canned in light syrup 1 11 ND 13 Oroblanco 2 3.7, , 4.9 ND Melogold ND Banpeiyu pummelo ND ND Akunebuntan pummelo 1 ND ND ND Suishobuntan pummelo 1 ND ND ND Tosabuntan pummelo 1 ND ND ND Iyokan 1 ND ND ND Satsuma mandarins 1 ND ND ND Kumquats 1 ND ND ND Setoka 1 ND ND ND Sweet spring 1 ND ND ND Dekopon tangor 2 ND ND ND Natsumikan 1 ND ND ND Hassaku 1 ND ND ND Pearl-kan 1 ND ND ND Hyuganatsu 1 ND ND ND Ponkan 1 ND ND ND Lemons 1 ND ND ND ND: not detected 200 g g 400 g FC FC 14,000 HPLC FC 311 nm FC BG 0 32 mg/g DHB 0 11 mg/g BT 0 39 g/g ml mg 10 mg FC BG mg/g, DHB mg/g, BT 0 28 mg/g mg FC FC 20 FC FC ) (ISBN ) 2) 109, , (2006). 3) Yamazoe, Y. Properties of grapefruit juice-drug interaction. Rinsho-Yakuri No Shimpo (Recent Advances in Clinical Pharmacology), 21, (2000). 4) (ISBN ) 5) Boullata, J. I., Armenti, V. T. Handbook of drugnutrient interactions (ISBN )
6 August ) Uesawa, Y., Mohri, K. Comprehensive determination of furanocoumarins derivatives in citrus juice by high performance liquid chromatography. Yakugaku Zasshi (Journal of the Pharmaceutical Society of Japan), 125, (2005). 7) Orii, Y., Tsuboi, T., Tanigawa, T., Hashizume, N., Kawano, K. Specificity of chemical comstituents in grapefruits juice which are known to inhibit CYP3A4 activity. Jpn. J. Clin. Pharmacol. Ther., 30, ) Ohtani, M., Kawabata, S., Kariya, S., Uchino, K., Itou, K., Kotaki, H., Kasuyama, K., Morikawa, A., Seo, I., Nishida, N. E#ect of grapefruit pulp on the pharmacokinetics of dihydropyridine calcium antagonists Nifedipine and Nisoldipine. Yakugaku Zasshi (Journal of the Pharmaceutical Society of Japan), 122, (2002). 9) Widmer, W., Haun, C. Variation in furanocoumarin content and new furanocoumarin dimmers in commercial grapefruit (Citrus paradisi Macf.) juices. J. Food Sci., 70, (2005). 10) De Castro, W. V., Mertans.-Talcott, S., Rubner, A., Butterweck, V., Derendorf, H. Variation of flavonoids and furanocoumarin in grapefruit juices: A potential source of variability in grapefruit juice-drug interaction studies. J. Agric. Food Chem., 54, (2006). 11) Manthey, J., A., Buslig, B. S. Distribution of furanocoumarin in grapefruit juice fractions. J. Agric. Food Chem., 53, (2005). 12) Uesawa, Y., Mohri, K. E#ects of sweetie juice on nifedipine pharmacokinetics in rats. Yakugaku Zasshi (Jounal of the Pharmaceutical Society of Japan), 125, (2005). 13) Mohri, K., Uesawa, Y. E#ects of furanocoumarin derivatives in grapefruit juice on nifedipine pharmacokinetics in rats. Pharmaceutical Reserch, 18, (2001). 14) Fukuda, K., Guo, L., Ohashi, N., Yoshikawa, M., Yamazoe, Y. Amounts and variation in grapefruit juice of the main components causing grapefruit-drug interaction. J. Chromatogr. B. Biomed. Sci. Appl., 741, (2000). 15) Saita, T., Fujito, H., Mori, M. Screening of furanocoumarin derivatives in citrus fruits by enzyme-linked immunosorbent assay. Biol. Pharm. Bull., 27, (2004).
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