Standardization, validation and outcome of double-blind, placebo-controlled food challenges in children Vlieg-Boerstra, Berber

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1 University of Groningen Standardization, validation and outcome of double-blind, placebo-controlled food challenges in children Vlieg-Boerstra, Berber IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2008 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Vlieg-Boerstra, B. (2008). Standardization, validation and outcome of double-blind, placebo-controlled food challenges in children s.n. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date:

2 Standardization, validation and outcome of double-blind, placebo-controlled food challenges in children

3 The publication of this thesis was financially supported by Nutricia Nederland B.V., Phadia B.V., ALK-Abelló B.V., UCB Pharma B.V., Stichting Astma Bestrijding, Graduate School for Drug Exploration (GUIDE), Rijksuniversiteit Groningen, Alpro Soya Nederland B.V., Friso Kindervoeding, Mead Johnson Nutritionals, Nederlandse Zuivel Organisatie. ISBN: B.J. Vlieg-Boerstra All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means, without permission from the author. About the cover Incrementing amounts of challenged foods as sequentially administered in test food material in the double-blind, placebo-controlled food challenge (DBPCFC) and subsequent open challenge or home introduction in children at the Food Challenge Unit of the University Medical Center Groningen Photograph: Bert L. Tebbes, medial photographer of the Department of Plastic Surgery, University Medical Center Groningen Page layout: Peter van der Sijde, Groningen, the Netherlands Printed by: Drukkerij van Denderen B.V., Groningen, the Netherlands

4 Standardization, validation and outcome of double-blind, placebo-controlled food challenges in children Proefschrift ter verkrijging van het doctoraat in de Medische Wetenschappen aan de Rijksuniversiteit Groningen op gezag van de Rector Magnificus, dr. F. Zwarts, in het openbaar te verdedigen op woensdag 20 februari 2008 om uur door Berber Johanna Vlieg-Boerstra geboren op 4 augustus 1960 te Den Haag

5 Promotores: Copromotores: Prof. dr. A.E.J. Dubois Prof. dr. E.J. Duiverman Dr. S. van der Heide Dr. C.M.A. Bijleveld Beoordelingscommissie: Prof. dr. S.L. Taylor Prof. dr. R. Gerth van Wijk Prof. dr. C.A.F.M. Bruijnzeel-Koomen

6 Aan mijn echtgenoot Henk mijn kinderen Marenne en Miriam Our little systems have their day; They have their day and cease to be: They are but broken in lights of thee And thou, O Lord, art more than they. Alfred Tennyson ( ) 1849, In Memoriam A.H.H

7 Paranimfen: Henk Vlieg Nadine Kuijpers

8 Contents Chapter I General introduction 9 Chapter II Development and validation of challenge materials 19 for double-blind, placebo-controlled food challenges in children Chapter III Published recipes for double-blind, 37 placebo-controlled food challenges (letter) Chapter IV Placebo reactions in double-blind, 41 placebo-controlled food challenges in children Chapter V Ready-to-use introduction schedules for first 57 exposure to allergenic foods in children at home Chapter VI Dietary assessment in children adhering to a food 71 allergen avoidance diet for allergy prevention Chapter VII Should children with a history of anaphylaxis to 85 foods undergo challenge testing? Chapter VIII General Discussion 101 Chapter IX Summary & Samenvatting 119 Dankwoord (acknowledgements) 127 About the author 131 List of publications 132

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