Synergies in Food Allergy Activities USA-EU. Steve L. Taylor, Ph.D. Food Allergy Research & Resource Program University of Nebraska
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1 Synergies in Food Aergy Activities USA-EU Steve L. Tayor, Ph.D. Food Aergy Research & Resource Program University of Nebraska
2 We Are A in This Together Anne Munoz-Furong, CEO Food Aergy & Anaphyaxis Network USA
3 Food Aergy Research - USA Cinica Research - Much focused on improved treatment strategies Consumer Research Basic Research (aergen characterization) Aergenicity Assessment (GMOs) Food Industry-Focused Research Food Aergy Research and Resource Program 2007
4 Food Industry Focused Activities Food Aergy Research & Resource Program - Research - Industry Outreach/Training Food Aergy Research and Resource Program 2007
5 FARRP CONSORTIUM Advance Food Company Agrana Fruit (Austria) Ajinomoto (Japan) Amy s s Kitchen ADM Barry Caebaut (France) Bommer Chocoate Bue Diamond Growers Bodendorfer-Johnson Bunge Miing Cadbury (U.K.) Campbe Soup Company Cargi Charm Sciences Chr. Hansen (Denmark) Coca Coa ConAgra Foods Continenta Mis Danone (France) DSM (Switzerand) Neogen Corp. Ecoab Neste (Switzerand) Genera Mis Newy Weds Foods Gerber Products Norand Products. Givaudan Favors (Switzerand) PepsiCo, Inc. Hain Ceestia Procter & Gambe H. C. Bri Raston Foods Hershey Foods r-biopharm (Germany) H. J. Heinz Sara Lee John B. Sanfiippo Schweppes America Beverages Keogg Sensient Favors Kerry Ingredients Soae Company Keystone Foods Tate & Lye (U.K.) Kraft Foods Uniever (U.K.) Laemand (Canada) Wm. Wrigey Jr. Company Mat-o-Mea Mea Manidra (Austraia) Mars Snackfood McCormick & Co. Food Aergy Research and Resource Program 2007
6 FARRP AG BIOTECH CONSORTIUM Monsanto DuPont Dow Agrosciences Syngenta (U.K.) Bayer (France) BASF (Germany) Food Aergy Research and Resource Program 2007
7 FOOD ALLERGY RESEARCH Steve L. Tayor Rick Goodman Searching for one more facuty position Food Aergy Research and Resource Program 2007
8 FARRP Facts Strong industry research support Strong internationa reputation Graduate students (3 Ph.D.; 5 M.S.) Postdocs (1) Grants (over $1 miion per year from industry, trade associations, government EPA, USDA) Food Aergy Research and Resource Program 2007
9 FARRP Research Provide food industry with toos to evauate aergic risk associated with products and processing Deveop scientific/cinica information to assist with risk assessment (fi the data gaps) Assess aergen contro strategies and deveop improved methods Coordinate cinica and basic research on food aergies wordwide Food Aergy Research and Resource Program 2007
10 FARRP Research Provide food industry with toos to evauate aergic risk associated with products and processing Deveop scientific/cinica information to assist with risk assessment (fi the data gaps) Assess aergen contro strategies and deveop improved methods Coordinate cinica and basic research on food aergies wordwide Food Aergy Research and Resource Program 2007
11 Rapid Methods for Detection of Aergenic Food Residues Deveop ELISAs Past projects: Peanut, mik, egg, amond, wanut, hazenut, pecan, shrimp, cam, sesame seed, soy four, parvabumin (fish) Current projects: Mustard, upine, cashew, buckwheat Food Aergy Research and Resource Program 2007
12 Rapid Methods for Detection of Aergenic Food Residues Deveop ELISAs Future projects:??? Other tree nuts (Brazi nut, pistachio, macadamia nut, pine nut, coconut), improved soy, fish, ceery Food Aergy Research and Resource Program 2007
13 Rapid Methods for Detection of Aergenic Food Residues Evauate/Perfect Anaytica Methods Past projects: Egg and processing; mik vs. casein and whey Current projects: ATP vs. ELISA; various grains and guten ELISAs, egg kit vaidation; effect of deep-fat frying Future projects: Many possibiities because testing must become more rugged Food Aergy Research and Resource Program 2007
14 Rapid Methods for Detection of Aergenic Food Residues Commerciaization of ELISAs Licensing agreement with Neogen Corporation: Kits for peanut, egg, mik, amond, hazenut, soy four, guten 96-we quantitative, swab tests, atera fow strips Food Aergy Research and Resource Program 2007
15 FARRP Research Provide food industry with toos to evauate aergic risk associated with products and processing Deveop scientific/cinica information to assist with risk assessment (fi the data gaps) Assess aergen contro strategies and deveop improved methods Coordinate cinica and basic research on food aergies wordwide Food Aergy Research and Resource Program 2007
16 Treatment for True Food Aergies Specific Avoidance Diets Food Aergy Research and Resource Program 2007
17 Exquisite Sensitivity of Some Food-Aergic Individuas Trace amounts of the offending food wi trigger reactions Food Aergy Research and Resource Program 2007
18 How Much is Too Much? Miigram amounts! (ppm concentrations) Food Aergy Research and Resource Program 2007
19 How Cean Is Cean Enough? The Coroary Question Food Aergy Research and Resource Program 2007
20 Why are we interested in Minima Eiciting Doses? Very sma amounts of specific aergens can provoke reactions in some individuas, but we don t t know in how many we don t t know how sma the amounts are we don t t know how severity of reaction reates to an individua s sensitivity aergic peope are known to react differenty on different occasions So it is difficut to assess how much needs to be done to achieve e the desired eve of safety with respect to aergens. Source: R. Creve, IUFoST - Chicago, Juy 2003
21 Minima eiciting doses and aergen risk management Labeing shoud be based on risk (i.e. No risk - no abe) Manufacturing practices shoud aim to reduce cross-contact contact aergen to safe eve (but not necessariy more) Risk assessment is required for both circumstances Food Aergy Research and Resource Program 2007 Source: R. Creve, IUFoST - Chicago, Juy 2003
22 Risk Assessment for Food Aergens
23 Risk Assessment Approaches to Evauation of Food Aergen Hazards FDA has determined that this is perhaps the best way to determine threshods for food aergens FDA has concuded that we do not have sufficient data for dose/response modeing Modeing is an accepted way of defining the probabiity of rare events with potentiay severe consequences Food Aergy Research and Resource Program 2007
24 Food Aergy Research and Resource Program 2007 Source: Bindsev Jensen et a. (2002)
25 FARRP Research Provide food industry with toos to evauate aergic risk associated with products and processing Deveop scientific/cinica information to assist with risk assessment (fi the data gaps) Assess aergen contro strategies and deveop improved methods Coordinate cinica and basic research on food aergies wordwide Food Aergy Research and Resource Program 2007
26 Determination of Minima Eiciting Dose for Commony Aergenic Foods Coaborative Cinica Trias Past Projects: Peanut, egg Current Projects: Shrimp, peanut-ii, soy four ILSI Interactions Modeing approaches w/uniever and ILSI Data mining w/d. A. Moneret-Vautrin (Nancy), ILSI, EuroPreva Exposure assessment w/ilsi, FAAN, FARRP Anaytica Lab. Bioogica mechanisms mode w/ilsi, FDA Food Aergy Research and Resource Program 2007
27 Aergenicity Assessment of Nove Foods and Ingredients Past Projects: Assessment of aergenicity of hardy kiwi (Goodman); cinica tria of fish geatin (Tayor); parvabumin in fish geatin and isingass (Goodman and Tayor); cincia tria of isingass (Tayor); assessment of aergenicity of basic mik protein (Goodman); assessment of aergenicity of barey b-gucan b (Tayor); cinica tria of refined soybean oi (Tayor) Current Projects: Assessment of aergenicity of canoa protein isoate (Goodman) Food Aergy Research and Resource Program 2007
28 Methods for Assessment of Aergenicity of GM Foods AergenOnine: peer-viewed database of sequences of known aergenic proteins used for sequence identity/homoogy comparisons (Goodman) Deveop antigen-specific IgE methods for evauating the in vitro cross-reactivity reactivity between GM proteins and known aergens improvement of serum screening strategies; differentiate binding to proteins and to carbohydrates (Goodman) Evauate use of 35% identity over 80 amino acid segments criterion to identify potentia aergenic proteins (Goodman) Food Aergy Research and Resource Program 2007
29 FARRP Research Provide food industry with toos to evauate aergic risk associated with products and processing Deveop scientific/cinica information to assist with risk assessment (fi the data gaps) Assess aergen contro strategies and deveop improved methods Coordinate cinica and basic research on food aergies wordwide Food Aergy Research and Resource Program 2007
30 Aergen Contro Strategies Food Aergy Research and Resource Program 2007
31 FARRP Research Provide food industry with toos to evauate aergic risk associated with products and processing Deveop scientific/cinica information to assist with risk assessment (fi the data gaps) Assess aergen contro strategies and deveop improved methods Coordinate cinica and basic research on food aergies wordwide Food Aergy Research and Resource Program 2007
32 FARRP Coaborations Extensive research and cinica coaborations USA, U.K., France, Denmark, Ireand, Switzerand, Japan, Germany, Netherands, South Africa, India EuroPreva?? Opportunities with threshod research (shrimp, modeing) Food Aergy Research and Resource Program 2007
33 FOOD ALLERGY EXTENSION Steve L. Tayor Rick Goodman Food Aergy Research and Resource Program 2007
34 FARRP Consumer Education Web site ( Partnerships with consumer organizations Food Aergy & Anaphyaxis Network (FAAN) Ceiac Sprue Association (CSA) Anaphyaxis Canada Anaphyaxis Campaign (U.K.) One-on on-one one assistance Consumers Physicians Attorneys Pubic Heath Professionas Food Aergy Research and Resource Program 2007
35 FARRP Industry Education Industry Workshops Food Aergen Workshops (1-2 2 per year) Food Aergen Sanitition Workshops (1-2 2 per year) Anaytica Methods for Food Aergens Conference (ea. 1.5 years) (partnership with Heath Canada) Internationa Threshod Roundtabe Conferences (3 so far) Food industry seminars and presentations (25-30 per year) Ag biotechnoogy seminars and presentation (7-10 per year) AergenOnine free pubic access One-on on-one one Assistance ( contacts per month) Food Aergy Research and Resource Program 2007
36 FARRP Industry Education Educationa Materias Training video in Engish, Spanish and French in VHS and PAL formats (partnership with Siiker) Food Aergen Databases Pubished iterature (>15,000 pubications) Fataity registry Reca database (FDA, USDA, CFIA) FARRP Website Pubic Site Members-ony Site FARRP Newsetters Food Aergy Research and Resource Program 2007
37 FARRP Proprietary Services FARRP Anaytica Laboratory industry sampes in $630,000 income generation from fee-for for-service - Anaysis for peanut, mik, egg, amond, hazenut, wanut, pecan, soy four, crustacean shefish, sesame seed, cam, mustard, guten (wheat, rye, barey) Food Aergy Research and Resource Program 2007
38 EuroPreva - FARRP Future Coaborations?? Open for further discussion Food Aergy Research and Resource Program 2007
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