GEORGE J. SOLEAS, B.Sc., M.Sc., Ph.D.

Transcription

1 GEORGE J. SOLEAS, B.Sc., M.Sc., Ph.D Clubview Drive Office: (416) Burlington, Ontario Fax: (416) L7M 4R3 Home: (905) CAREER SUMMARY A Professional with 24 years of in depth and diverse technical experience, integrating Management, Business, Research, Quality Management and Creative Solving Skills. CAREER HISTORY LIQUOR CONTROL BOARD OF ONTARIO (LCBO) 1997-Present Vice President, Quality Assurance Head Office, Toronto, Ontario Directs the activities and requirements of the LCBO Quality Assurance Laboratories and Quality Services. QA Vision: Quality Safety Innovation QA Core Values: Client Satisfaction Excellence through quality management Continuous improvement Employee growth QA Mission: Committed to providing testing and quality services to the highest standards through good professional practice and client-focused quality objectives and continual improvement of its quality management system, designed to meet the ISO 9001:2000 and ISO/IEC 17025:1999 standards, The LCBO Quality Assurance Department takes a leading role in the implementation of the

2 G.J. (George) Soleas 2 LCBO policy to assure that beverage alcohol products sold through the LCBO are in compliance with federal and provincial regulations, are of sound quality, and are safe for consumption. It fulfills this role by providing expert services in analytical chemistry, packaging and label review, sensory analysis, alcoholic beverage knowledge, and the monitoring, investigation and resolution of internal and external client complaints/issues. This expertise is used to approve, reject or recall products and provide information on alcoholic beverage quality as required. The Quality Assurance Department provides the only reference laboratory for the analysis of contraband beverage alcohol products in Ontario. It has an international reputation and undertakes research and development projects in partnership with other organizations as well as providing services on a contract basis. Works independently within LCBO policies and objectives often recommending changes in policies and objectives. Applies judgement in analyzing broad problems and develops solutions, often where methods and policies are inadequate or not established. Exercises judgement in establishing and evaluating personnel and operational activity and determining appropriate action. Represents the LCBO/MEDT in Inter-Agency Council on Food Safety, O.I.V. and CCOVI-Brock University. Member of the LCBO Executive Team. Member of the Expert Committee of the World Wide Trade Group (WWTG). Develops the short term and long term Business Plans and prepares the departments operational and capital budgets and administers cost controls. Chairs the National Quality Assurance Committee of the Canadian Association of Liquor Jurisdictions (CALJ). Presents at National and International conferences. Major Accomplishments: Implemented a cost recovery program by introducing laboratory fee, collaborating on research projects with private industry and by offering thelaboratory services to private industry. Introduced efficiency/productivity programs:

3 G.J. (George) Soleas 3 Reducing/streamlining testing where possible. Maximizing resources. Implementing state-of-the-art automated technology. Improving processes, method capabilities, equipment efficiencies and minimizing instrument downtime. Providing relevant training. Re-structured, re-organized and re-focused the QA Laboratory and Quality Services activities and created a change ready team and a seamless environment between the two groups. Introduced communication channels between management and staff within Quality Assurance and QA-clients (internal and external) and created a customer service oriented environment. Improved the turn-around-time of reporting results from 18 to 3.0 working days by introducing efficiencies into the system. Implemented client satisfaction surveys for internal and external customers, resulting in specific business initiatives. Guided the QA-team to achieve ISO registration and ISO/IEC accreditation, the first Liquor Jurisdiction in the world to be doubly accredited. Initiated the re-engineering of the Lab-Information Management System to a completely configurable system adaptable to our changing business requirements with major productivity and capability improvements. Created a self-containment laboratory for the analysis of contraband products, improved the security of the QA Laboratory and enhanced the chain-of-custody process of all samples submitted to QA. Expanded the fingerprinting/profiling capabilities by adding high-tech Isotopic Ratio Mass Spec. instrumentation. Initiated the Review of the LCBO Packaging Guidelines utilizing outside consultants. Oversaw the migration of all Quality Control contacts from the Retail Service Centres to Quality Assurance. Oversaw the re-engineering of the sensory grading system utilizing state-of-the-art sensory evaluation software by Compusense Inc. creating a unique to the industry system. Authored and co-authored several publications and abstracts (Appendix III & IV).

4 G.J. (George) Soleas 4 ANDRES WINES LTD Manager, R & D and Quality Control Head Office, Winona, Ontario Reported to the Senior Vice President, Operations Directed the activities and requirements of the Research & Development and Quality Control laboratories i) instrumentation and methodologies ii) applied for research grants iii) conducted interviews for research and quality control staff/labour distribution iv) capital costs/annual v) developed and co-ordinated research projects corporately vi) provided technical support to winemakers and technical personnel corporately. Evaluated and recommended R & D projects, proposals, methodologies, data, instrumentation and QA/QC programs. Chaired the Technical/Scientific committee of the Canadian Wine Institute since1987. Involved in the purchase of raw materials such as wine and grape must from around the globe. Involved in new product development, shelf-life studies and sensory evaluations. Attended meetings of technical and production management personnel. Trained personnel on WHMIS and other safety issues. Represented the company on environmental issues such as the MISA program, MOE and Federal guidelines on drinking water and waste treatment technologies. Presented on National and International technical and scientific conferences. Prepared the annual budget for the Research & Quality Control laboratories and personnel. Major Accomplishments:

5 G.J. (George) Soleas 5 Reorganized the R & D and QA/QC facilities and provided direction for new research and high-tech instrumentation. Achieved Certification for Andres wines R & D laboratories for the analysis of Ethyl Carbamate under the H.P.B. program. Presented papers on Ethyl Carbamate, Pesticide residues, Wine phenolics and Health Benefits of wine at National and International Conferences and participated as a panelist on various scientific discussions. Initiated and completed Research projects on the production of wine and sherry with low Ethyl Carbamate concentrations. Established external analytical services (Canadian & U.S.) for the analysis of various parameters in wine, resulting in more than $800K revenue for R & D and QA/QC laboratories. Consulted for and implemented waste water and drinking water quality control programs for all Andres regional operations. Initiated and implemented Quality Control/Assurance programs for the analysis of pesticide residues, ethyl carbamate, metals and other parameters in concentrate, juice and wine products. Represented Andres Wines Ltd. and the Canadian Wine Institute on National and International conferences such as AOAC, IUPAC, ASEV, OIV, Pesticide Residue conferences, etc. Applied and received grants exceeding $600,000 from the National Research Council of Canada (Appendix II). Provided direction to the wine industry on the issues of FAS/FAE and of. Sulfites and presented the industry s case to the Health Committee of the House of Commons. STELCO INC., LAKE ERIE WORKS, NANTICOKE Chemist, Primary Chemical Laboratory Nanticoke, Ontario Developed new methods for the analysis of raw materials, finished products and byproducts of the steel and iron industry.

6 G.J. (George) Soleas 6 Prepared and use methods approved by the Ministry of the Environment to analyze and report organic and inorganic parameters in waste water effluents, sludge,drinking water and Biological Treatment Plant effluents. Prepared water quality reports on weekly and monthly basis and make recommendations on some water quality related problems and sampling procedures. Conducted laboratory quality control programs to ensure accuracy and precision of reported results. Advised on new project proposals and methodologies. Applied Statistical Process Control methods on all results produced by the labs. Trained as a project metallurgist on the coke ovens and Blast Furnace operations. ENVIRONMENT CANADA (CCIW), BURLINGTON, ONTARIO Chemical Analyst, Organic Analysis lab; Water Quality Branch Burlington, Ontario EDUCATION B.Sc. - McMaster University (1981)

7 G.J. (George) Soleas 7 Major Subjects: Chemistry & Biochemistry M.Sc. University of Toronto (1997) M.Sc. Thesis title: The Analysis of Polyphenolic Constituents in Wine and Their Relationship to Antioxidant Activity Ph.D. - University of Toronto (2001) Ph.D. Thesis title: Analytical and Biochemical Aspects of Wine constituents that Affect Human Health Hotel Business Diploma - Hotel & Catering Institute of Cyprus ( ) Certificate in Metallurgy - McMaster University (1985) AFFILIATIONS National Quality Assurance Committee (CALJ) Expert Committee World Wide Trade Group (WWTG) Inter-Agency Council on Food Safety Advisory Board of CCOVI Brock University Research Committee CCOVI Brock University Chemical Institute of Canada American Society of Enology & Viticulture Association of Chartered Chemists Alumni of McMaster University & University of Toronto Reviews for: Journal of Chromatography, Journal of Agriculture and Food Chemistry, Journal of Enology & Viticulture Italian Journal of Food Science Food Chemistry

8 APPENDIX I PROFESSIONAL DEVELOPMENT Leading & Managing Organizational change Athabasca University Supervisory Training Course - McMaster University Economic 1A6 McMaster University Interaction Management Studies - Development Dimensions International Strategic Planning - Kinetics Consultants Inc. - Vancouver, B.C. Supervisory Skills course - U.B.C. Enology: Several Winemaking Courses - University of California, Davis, CA. Winery Sanitation Workshop - ASEV (Anaheim, CA) Statistical Process Control Certificate - S.P.C. Quality Assurance Principles for Analytical Labs - AOAC Train the Trainer Certificate (WHMIS) IAPA Statistics for Methodology - AOAC Statistical Analysis of Agri-Food Experiments - University of Guelph Various courses and workshops on various analytical instruments Windows, Microsoft Word, Excel and Power Point

9 APPENDIX II RESEARCH GRANTS OBTAINED 1. Develop a method for the analysis of Organochlorinated & Organophosphorous pesticide residues in raw materials used in winemaking (Phase 1). June 15/ 87 - Oct. 16/1987; Amount = $6, Develop a method for the analysis of Organochlorinated & Organophosphorous pesticide residues in grape juice and finished wines (Phase 2). Oct. 19/ 87 - Feb. 19/1988; Amount = $6, Survey of OC & OP pesticide residues in Ontario grape juice and wines (Phase 3). May 09/ 88 - Sept. 09/1988; Amount = $6, Development of a method for the analysis of Carbamate pesticide residues in grape juice and wines. Sept. 12/ 88 - Jan. 14/1989; Amount = $6, Determination and Optimization of pesticide residue removal during vinification and wine processing (Phase 1). April 01/ 89 - Dec. 31/1989; Amount = $30, Determination and Optimization of pesticide residue removal during vinification and wine processing (Phase 2). Oct. 22/ 90 - Mar. 31/1991; Amount = $29, Development of a GC/MS assay to analyze for resveratrol in grape juice and wine (Collaboration with Dr. D. M. Goldberg and Dr. E. P. Diamandis). Jan. 04/ 93 - April 30/1993; Amount = $28, Develop Technology to enhance the extraction of wine phenolics & resveratrol in Canadian wines (Collaboration with Dr. D. M. Goldberg and Dr. E. P. Diamandis). Dec. 04/ 93 - Dec. 31/1994; Amount = $100, Develop an assay to survey Biogenic amines in Ontario wines. Jan. 02/ 95 - April 30/1995; Amount = $9, Develop technology to enrich wines with phenolics and validate their antiatherosclerosis properties. (Collaboration with Dr s K. Ingold, (S.I.M.S.), D.M. Goldberg, (U. of T.) and E.P. Diamandis, Mount Sinai/U. of T.). July 01/ 95 - Mar. 31/ 1997; Amount = $250,000.00

10 11. Enhancement of grape concentrate with oak extracts. Mar. 03/ 97 - May 31/1997; Amount = $10, Development of an Assay for the Analysis of 2,4,6-Trichloroanisole in Wine and Corks. (Collaboration between Vincor Int. Inc. and LCBO). Dec. 01/ 97 - Mar. 30/1998; Amount = $15, Contribution of Wood Extract and Micro-Oxygenation to Wine and the Effect on the Biological Activity of Wine Polyphenols. (Collaboration between Andres Wines Ltd., LCBO and the University of Toronto). June 1/ 98 - May 30/1999; Amount = $100, Feasibility of Developing a Process to Evaluate corks and to Exclude Those with unacceptably High 2,4,6-Trichloroanisole Content. (Collaboration between Vincor Inc., LCBO and Mount Sinai). Sept.01/ 98 - Aug. 31/1999; Amount = $90, Development of an Extraction Process for the recovery of natural antioxidants from grape vine cuttings. (Collaboration between Inniskillin Wines and LCBO) June 30/ 01 - June 29/2002; Amount = $135, Control of MALB in Niagara Vineyards. (On sub-contract basis with Inniskillin Wines) September 1/04 - August 30/2005; Amount = $ 50,000

11 APPENDIX III BOOK CHAPTERS 1. D.M. Goldberg, G.J. Soleas, S.E. Hahn, E.P. Diamandis. Identification and Assay of Trihydroxystilbenes in Wine and their Biological properties. In: Composition and Health Effects of Wine, T. Watkins (ed), pp.24-43, American Chemical Society, Washington. D.C. 2. D.M. Goldberg, G.J. Soleas. Determination of Polyphenolic Antioxidants of Wine by High Performance Liquid Chromatography. In: Methods in Enzymology. L. Packer (ed), Vol. 299 (Part A) pp , 1998, Academic Press, San Diego 3. G.J. Soleas, D.M. Goldberg. Determination of Polyphenolic Antioxidants of Wine by Gas Chromatography with Mass-Selective Detection. In: Methods in Enzymology. L. Packer (ed), Vol 299 (Part A), pp , 1998, Academic Press, San Diego. 4. G.J. Soleas, E.P. Diamandis, D.M. Goldberg. The World of Resveratrol. In: Nutrition and Cancer Prevention: New Insights into the Role of Phytochemicals. Adv. Exp. Med. Biol. 492: , D.M. Goldberg, G.J. Soleas. Beverage Alcohol Consumption as a Negative Risk Factor for Coronary Heart Disease: Biochemical Mechanisms. In: Health Effects of Alcohol Intake. D.P. Agarwal and H.K. Seitz (eds), pp , 2001, Marcel Decker, New York. 6. G.J. Soleas, J. Yan, D.M. Goldberg. The Measurement of trans-resveratrol, (+)-Catechin and Quercetin in Rat and Human Blood and Urine by Gas Chromatography with Mass Selective Detection. In: Methods in Enzymology. L. Packer (ed), Vol. 335, pp , 2001 Academic Press, San Diego. 7. G.J. Soleas, M. Angelini, L. Grass, E.P. Diamandis, D.M. Goldberg. On the Absorption of trans-resveratrol in the Rat. In Methods in Enzymology. L. Packer (ed), Vol. 335, pp , 2001 Academic Press, San Diego. 8. D.M. Goldberg, G.J. Soleas. Resveratrol: Biochemistry, Cell biology and the Potential Role in Disease Prevention. In: Wine A Scientific Exploration. M. Sandler and R. Pinder (ed), pp , 2003 Taylor & Francis Inc, New York.

12 APPENDIX IV INVITED REVIEWS 1. G.J. Soleas, E.P. Diamandis, D.M. Goldberg. Resveratrol: A Molecule Whose Time has Come? and Gone? Clin. Biochem, 30: , G.J. Soleas, E.P. Diamandis and D.M. Goldberg. Wine as a Biological Fluid:History,Production, and Role in Disease Prevention. J. Clin. Lab. Anal. 11: , D.M. Goldberg, G.J. Soleas and M. Levesque. Moderate Alcohol Consumption: TheGentle Face of Janus. Clin. Biochem. 32: , ORIGINAL SCIENTIFIC PAPERS 1. D.M. Goldberg, J. Yan, E. Ng, E.P. Diamandis, A. Karumanchiri, G. Soleas, A.L. Waterhouse. Direct Injection Gas Chromatographic Mass Spectrometric Assay for trans-resveratrol. Anal. Chem. 66: , D.M. Goldberg, J. Yan, E. Ng, E.P. Diamandis, A. Karumanchiri, G. Soleas, A. Waterhouse. A Global Survey of Trans-Resveratrol Concentration in Commercial Wines. Am. J. Enol. Vitic. 46: , G.J. Soleas, D.M. Goldberg, E.P. Diamandis, A. Karumanchiri, J. Yan, E. Ng. A Derivatized Gas Chromatographic-Mass Spectrometric Method for the Analysis of Both Isomers of Resveratrol in Juice and Wine. Am. J. Enol. Vitic. 46: , D.M. Goldberg, A. Karumanchiri, E. Ng, J. Yan, E.P. Diamandis, G.J. Soleas. Direct Gas Chromatographic-Mass Spectrometric Method to Assay-Cis- Resveratrol in Wines: Preliminary Survey of its Concentration in Commercial Wines. J. Agric. Food Chem.43: , C.R. Pace-Asciak, S.E. Hahn, E.P. Diamandis, G. Soleas, D.M. Goldberg. The Red Wine Phenolics Trans-Resveratrol and Quercetin Block Human Platelet Aggregation and Eicosanoid Synthesis: Implications for Protection Against Coronary Heart Disease. Clin. Chim. Acta. 235: , G.J. Soleas, D.M. Goldberg, A. Karumanchiri, E.P. Diamandis, Ng, E. Influences of Viticultural and Oenological Factors on Changes in Cis- and Trans-Resveratrol in Commercial Wines. J. Wine Res. 6: , D.M. Goldberg, E. Ng., A. Karumanchiri, J. Yan, E.P. Diamandis, G.J. Soleas. Assay of Resveratrol Glucosides and Isomers in Wine by Direct-Injection High- Performance Liquid Chromatography. J. Chromatogr. A. 708: 89-98, 1995.

13 8. D.M. Goldberg, E. Ng, J. Yan, A. Karumanchiri, G.J. Soleas, E.P. Diamandis. Regional Differences in Resveratrol Isomer Concentrations of Wines from Various Cultivars. J. Wine Res. 7: 13-24, D.M. Goldberg, E. Tsang, A. Karumanchiri, E.P. Diamandis, G.J. Soleas, E. Ng. A Method to Assay the Concentrations of Phenolic Constituents of Biological Interest in Wines. Anal. Chem. 68: , D.M. Goldberg, E. Ng, A. Karumanchiri, E.P. Diamandis, G.J. Soleas. Resveratrol Glucosides are Important Components of Commercial Wines. Am. J. Enol. Vitic. 47: , G.J. Soleas, D.M. Goldberg, E. Ng. A. Karumanchiri, E. Tsang, E.P. Diamandis. Comparative Evaluation of Four Methods for Assay of Cis and Trans-Resveratrol. Am.J. Enol. Vitic. 48: , G.J. Soleas, E.P. Diamandis, A. Karumanchiri and D.M. Goldberg. A Multiresidue Derivatization Gas-Chromatographic Assay for Fifteen Phenolic Constituents with Mass Selective Detection. Anal. Chem. 69: , G.J. Soleas, J. Dam, M. Carey, E.P. Diamandis and D.M. Goldberg. Towards the Fingerprinting of Wines: Cultivar Related Patterns of Polyphenolic Constituents in Ontario Wines. J. Agric. Food Chem. 45: , G.J. Soleas, G. Tomlinson, E.P. Diamandis and D.M. Goldberg. The Relative Contributions of Polyphenolic Constituents to the Antioxidant Status of Wines: Development of a Predictive Model. J. Agric. Food Chem. 45: , D.M. Goldberg, A. Karumanchiri, E. Tsang, E.P. Diamandis and G.J. Soleas. Catechin and Epicatechin Concentrations of Red Wines: Regional and Cultivar- Related Differences. Amer. J. Enol. Vitic. 49: 23-34, D.M. Goldberg, E. Tsang, A. Karumanchiri and G.J. Soleas. Quercetin and p- Coumaric Acid Concentrations in Commercial Wines. Amer. J. Enol. Vitic. 49: , G.J. Soleas, G. Tomlinson and D.M. Goldberg. Kinetics of Polyphenol Release into Wine Must During Fermentation of Different Cultivars. J. Wine Res. 9: 27-41, G.J. Soleas, M. Carey and D.M. Goldberg. Biogenic Amines: Cultivar-Related Differences in Ontario Wines. Food Chem. 64: 49-58, 1999.

14 19. D.M. Goldberg, G.J. Soleas and A Karumanchiri. Iprodione Content of Wine: Where do we Draw the Line.? J. Wine Res. 9: 27-41, D.M. Goldberg, A. Karumanchiri and G.J. Soleas. Concentrations of Selected Polyphenols in White Commercial Wines. Amer. J. Enol. Vitic. 50: , D.M. Goldberg, M. Levesque, E. Tan and G.J. Soleas. Comparative Evaluation of Two HPLC Methods to Assay Resveratrol Glucosides in Commercial Wines. J. Liquid Chromatogr. 22: , D.M. Goldberg, B. Hoffman, J. Yan and G.J. Soleas. Phenolic Constituents, Furans, and Total Antioxidant Status of Distilled Spirits. J. Agric. Food Chem. 47: , D.M. Goldberg, J. Dam, M. Carey and G.J. Soleas. Cultivar-Specific Patterns of Polyphenolic Constituents in Wines from New York State. J. Wines Res. 11: , G.J. Soleas and D.M. Goldberg. Potential Role of Clarifying Agents in the Removal of Pesticide Residues During Wine Production and Their Effects upon Wine Quality. J. Wine Res., 11:19-34, G.J. Soleas, J. Yan, K. Hom and D.M. Goldberg. A Multiresidue Gas Chromatographic Method for the Analysis of Seventeen Pesticides in Wine with Mass Selective Detection. J. Chromatogr. 882: , G.J. Soleas, P.D. Josephy, E.P. Diamandis and D.M. Goldberg. A Comparison of the Anticarcinogenic Properties of Four Red Wine Polyphenols. Proc. OIV Congress, Adelaide, Australia, G.J. Soleas, J. Yan and D.M. Goldberg. Assay of Ochratoxin A in Wine and Beer by High-Pressure Liquid Chromatography Photodiode Array and Gas Chromatography Mass Selective Detection. J. Agric. Food Chem. 49: , G.J. Soleas, J. Yan and D.M. Goldberg. Ultrasensitive Assay for Three Polyphenols (Catechin, Quercetin and Resveratrol) and Their Conjugates in Biological Fluids Utilizing Gas Chromatography With Mass Selective Detection. J. Chromatogr. B. 757: , G.J. Soleas, D.M. Goldberg, L. Grass, M. Levesque and E.P. Diamandis. Do Wine Polyphenols Modulate P53 Gene Expression in Human Cancer Cell Lines? Clin Biochem. 34: , 2001.

15 30. G.J. Soleas, J. Yan, T. Seaver and D.M. Goldberg. A Method for the Gas- Chromatographic Assay with Mass Selective Detection of Trichloro-Compounds in Corks and Wines Applied to Elucidate the Potential Cause of Cork Taint. J. Agric. Food Chem. 50: , G.J. Soleas, P.D. Josephy, E.P. Diamandis and D.M. Goldberg. A Comparison of the Anticarcinogenic Properties of Four Red Wine Polyphenols. Clin. Biochem. 35: , G.J. Soleas, L. Grass, P.D. Josephy, E.P. Diamandis, D.M. Goldberg. A Comparison of the Anticarcinogenic Properties of Four Red Wine Polyphenols. Bulletin O.I.V. 75: , D.M. Goldberg, J. Yan, G.J. Soleas. Absorption of Three Wine-related Polyphenols in Three Different Matrices by Healthy Subjects. Clin. Biochem. 36:79-87, G.J. Pickering, J.Y. Lin, R. Riesen, A. Reynolds, I. Brindle, G.J. Soleas. Influence of Harmonia axyridis on the Sensory Properties of White and Red Wine. Am. J. Enol. Vitic, G.J. Pickering, J.Y. Lin, A. Reynolds, G.J. Soleas, R. Riesen, I. Brindle. Harmonia axyridis and wine quality. (1) Wine composition and aging. Am. J. Enol. Vitic, submitted for publication, G.J. Pickering, J.Y. Lin, A. Reynolds, G.J. Soleas, R. Riesen, I. Brindle. Evaluation of remedial treatments for wine affected by Harmonia axyridis. Int. J. Food Sci and Technol., submitted for publication, ABSTRACTS 1. G.J. Soleas. Analysis of Ethyl Carbamate in Canadian wines. 39th Annual Meeting of American Society of Enology and Viticulture, Anaheim, California, G.J. Soleas. Multiresidue Method for the Determination of Pesticide Residues in Grape Juice and Wine. 40th Annual Meeting of American Society of Enology and Viticulture, Anaheim, Ca, G.J. Soleas, K. Papadopoulos, S. Sartor. Pesticide Residue Fate During Fermentation of Grape Juice to Wine. 42nd Annual Meeting of American Society of Enology and Viticulture, Seattle, Washington, 1991.

16 4. D.M. Goldberg, J. Yan, E. Ng, E.P. Diamandis, A. Karumanchiri, A.L. Waterhouse, G.J. Soleas. A Definitive Gas-Chromatographic Mass-Spectrometric Assay for Resveratrol Suitable for Industrial and Biological Samples. 37th Annual Conference of the Canadian Society of Clinical Chemists, Banff, Alberta, April Clin. Biochem. 26 (abst): , D.M. Goldberg, A. Karumanchiri, E. Eng, E.P. Diamandis, J. Yan, G.J. Soleas, A.L. Waterhouse. Resveratrol Content of Wines Assayed by a Direct Gas Chromatographic- Mass Spectrometric Technique. 44th Annual Meeting of the American Society for Enology and Viticulture, Sacramento, California, June Am.J. Enol. Vit. 44: 344 (abst.) G.J. Soleas, D.M. Goldberg, E.P. Diamandis, A. Karumanchiri, E. Ng, J. Yan. A Gas Chromatographic Mass Spectrometric Method for the Analysis of Resveratrol in Juice and Wine Samples. 44th Annual Meeting of the American Society for Enology and Viticulture, Sacramento, California, June Am. J. Enol. Vit. 44: (abst.) D.M. Goldberg, A. Karumanchiri, E. Ng, E.P. Diamandis, J. Yan and G.J. Soleas. A Direct GC-MS Assay for Cis-Resveratrol and a Preliminary Evaluation of its Concentration in Wines from Various Countries. 45th Annual Meeting of the American Society of Enology and Viticulture, Annaheim, California, July Am. J. Enol. Vitic. 45: 364 (abst.) G.J. Soleas, D.M. Goldberg, E.P. Diamandis, and A. Karumanchiri. Cis-Resveratrol and its Concentration Relative ot that of Trans-Resveratrol in Ontario Wines Analyzed by a GC/MSD Derivatization Method. 45th Annual Meeting of the American Society of Enology and Viticulture, Annaheim, California, July Am. J. Enol. Vitic. 45: 364 (abst.) D.M. Goldberg, E. Ng, A. Karumanchiri, E.P. Diamandis, G.J. Soleas. Resveratrol Glucosides are Important Flavonoid Components of Commercial Red Wines. 46th Annual Meeting of American Society of Enology and Viticulture, Portland, Oregan, June, Am. J. Enol. Vitic., 46: 400 (abst.) Karumanchiri, E. Tsang, E. Ng, D.M. Goldberg, G.J. Soleas, E.P. Diamandis. Analysis of Eight Wine Phenolics by Direct-Injection Gradient-Elution HPLC Coupled to a Diode Array Detector. Am. J. Enol. Vitic., 46: 409 (abst.) G.J. Soleas, E. Ng, J. Yan, A. Karumanchiri, E.P. Diamandis, D.M. Goldberg, Comparative Evaluation of Three methods for Assay of Cis- and Trans- Resveratrol. 46th Annual Meeting of American Society of Enology and Viticulture, Portland, Oregan, June, Am. J. Enol. Vitic., 46: 409 (abst.) 1995.

17 12. L. Tham, D.M. Goldberg, E.P. Diamandis, A. Karumanchiri, G.J. Soleas. Extraction of Resveratrol from Human Blood. 39th Annual Scientific Meeting, Canadian Society of Clinical Chemistry, Whistler, BC, April, Clin. Biochem., 28: 339 (abst.) D.M. Goldberg, L. Tham, E.P. Diamandis, A. Karumanchiri, G.J. Soleas. The Assay of Resveratrol and its Distribution in Human Blood. 47th Annual Scientific Meeting, American Association for Clinical Chemistry, Anaheim, CA, July, Clin. Chem., 41: S115 (abst.) D.M. Goldberg, G.J. Soleas, S.E. Hahn, E.P. Diamandis, A. Karumanchiri. Identification and Assay of Trihydroxystilbenes in Wine and their Biological Properties. By invitation, American Chemical Society National Meeting, Chicago, August A. Karumanchiri, E. Tsang, G.J. Soleas, E.P. Diamandis and D.M. Goldberg. The Concentrations of Quercetin and p-coumaric Acid in Commercial Wines. 47th Annual Meeting of the American Society for Enology and Viticulture, Reno, Nevada, June Am. J. Enol. Vitic. 47: 351 (abst.) G.J. Soleas, D.M. Goldberg, E.P. Diamandis, and A. Karumanchiri. A Derivatized Gas Chromatographic-Mass Spectrometric Multiresidue Method for the Analysis of Phenolic Acids in Wine. 47th Annual Meeting of the American Society for Enology and Viticulture, Reno, Nevada, June Am. J. Enol. Vitic. 47: 352 (abst.) A. Karumanchiri, E. Tsang, D.M. Goldberg, E.P. Diamandis, and G.J. Soleas. Catechin and Epicatechin Concentrations of Red Wines from 15 Different Regions. 47th Annual Meeting of the American Society for Enology and Viticulture, Reno, Nevada, June Am. J. Enol. Vitic. 47: 357 (abst.) D.M. Goldberg, A. Karumanchiri, G.J. Soleas, E. Tsang and E.P. Diamandis. Polyphenol Concentrations in White Commercial Wines. 48th Annual Meeting of the American Society for Enology and Viticulture, San Diego, California, July Am. J. Enol. Vitic. 48: 379 (abst.) G.J. Soleas, D.M. Goldberg, M. Carey, E.P. Diamandis and A. Karumanchiri. Biogenic Amines in Canadian Wines: How Big is the Problem? 48th Annual Meeting of the American Society for Enology and Viticulture, San Diego, California, July Am. J. Enol. Vitic. 48: 386 (abst.) 1997.

18 20. A. Karumanchiri, E.Tsang, G.J. Soleas, E.P. Diamandis, M. Levesque and D.M. Goldberg. Method-Dependent Bias in the Quantitation of Resveratrol Glucosides by High Performance Liquid Chromatography. 48th Annual Meeting of the American Society for Enology and Viticulture, San Diego, California, July Am. J. Enol. Vitic. 48: 389 (abst.) A. Karumanchiri, G.J. Soleas, E.P. Diamandis and D.M. Goldberg. Iprodione Content of Wine. Cause for Concern? 48th Annual Meeting of the American Society for Enology and Viticulture, San Diego, California, July Am. J. Enol. Vitic. 48: 389 (abst.) G.J. Soleas, E.P. Diamandis, G. Tomlinson, D.M. Goldberg. Identifying the Major Phenolic Antioxidants of Wine. 11th International Symposium on Atherosclerosis, Paris, Oct Atherosclerosis 134: 207 (abst.) D.M. Goldberg, A. Karumanchiri, G.J. Soleas, E. Tsang and E.P. Diamandis. Polyphenol Concentrations in White Commercial Wines. 48th annual Meeting of the American Society for Enology and Viticulture, San Diego, California, July Am. J. Enol. Vitic. 48: 379 (abst.) G.J. Soleas, D.M. Goldberg, M. Carey, E.P. Diamandis and A. Karumanchiri. Biogenic Amines in Canadian Wines: How Big is the Problem? 48th Annual Meeting of the American Society for Enology and Viticulture, San Diego, California, July Am. J. Enol. Vitic. 48: 386 (abst) G.J. Soleas, D.M. Goldberg. Phenolic Content of Wines from the Finger Lakes Region of New York State. 49th Annual Meeting of the American Society for Enology and Viticulture, Sacramento, California, June Am. J. Enol. Vitic. 49: 455 (abst.) G.J. Soleas, D.M. Goldberg. Assay of 2,4,6-Trichloroanisole in Corks and Wine. 49th Annual Meeting of the American Society for Enology and Viticulture, Sacramento, California, June Am. J. Enol. Vitic. 49: (abst.) G.J. Soleas, M. Angelini, E.P. Diamandis, D.M. Goldberg. The Absorption of trans- resveratrol in the rat. Annual Meeting, Canadian Cardiovascular Society, Quebec City, October 19-23, Can J Cardiol 15D: 210, (abst) G.J. Soleas, E.P. Diamandis, D.M. Goldberg, L. Grass. Do Alcoholic Beverages Prevent the Development of Atherosclerosis in the Rabbit? Annual Meeting, Canadian Cardiovascular Society, Quebec City, October 19-23, Can J Cardiol 15D: , (abst) G.J. Soleas, P.D. Josephy, E.P. Diamandis and D.M. Goldberg. A Comparison of the Anticarcinogenic Properties of Four Red Wine Polyphenols. 93 rd Annual Meeting, American Association for Cancer Research.

19 30. G.J. Pickering, J.Y. Lin, R. Riesen, A. Reynolds, I. Brindle, and G.J. Soleas. (2003). Impact of Harmonia axyridis (Asian Lady Beetle) on the Sensory Properties of White and Red Wine. Oral presentation to Vintners Quality Alliance-Ontario Winemakers Seminar, Brock University, 26 th March. 31. G.J. Pickering, Y. Lin, A. Reynolds, R. Riesen, G.J. Soleas, I. Brindle (2004). The Impact of Asian Lady Beetle (Harmonia axyridis) on Wine Quality. Poster presentation at the Ontario Fruit and Vegetable Convention, Brock University, St. Catharines, Ontario, th February, 2004.