Veterinary Product Catalog

Transcription

1 Veterinary Product Catalog 1

2 At ALK, we fight the cause of allergy and are in the forefront of developing evidence- based allergy immunotherapy treatments for the benefit of patients worldwide. Mission We improve the quality of life by fighting the cause of allergy. Vision In the global market for specific allergy treatment, we strengthen our leading position through our representation, acquisitions and partnerships. Our future is secured by a strong pipeline. We continuously launch new convenient products providing value to patients and society. We are driven by our customer focus and strong performance culture. We attract and retain dynamic and business-minded employees. Values Progressive, Focused, United, Trustworthy. These four values describe our corporate culture and set out the framework for our daily conduct and decisions

3 Table of Contents Introduction...5 Farm to Pharma...6 Allergen Extracts...7 Pollen Extracts...8 Molds Smuts Mites Insects Epidermals Diagnostic Controls Ancillary Products Normal Saline with Phenol (NSP) Pumps Colored Caps for Vials Syringes Trays Suggested Diagnostic Zones and Treatment Regions Cross Reactivity Weight to Volume Ordering Information Fax Order Form ACTT Allergy Program Contact Information... Back Cover 54 3

4 You have a choice for your allergy products. A pioneer in allergy immunotherapy. Since 1923, ALK has exemplified scientific leadership in the field of allergy research and in the treatment of allergic disease in humans. We are proud to extend our experience into the animal health industry by supporting veterinary dermatologists in the treatment of allergic pets. Benefits of partnering with ALK: Over 90 years experience of manufacturing allergenic extracts. Investing in allergic disease research for animals. Maintain dedicated Scientific Affairs team specializing in veterinary allergy to assist you with difficult cases and dose modification in your practice. ALK has 100% control of the extract manufacturing process and is 100% dedicated to allergic care

5 Bulk Allergens for Intradermal Testing and Treatment Formulation ALK is proud to offer bulk allergens for intradermal testing. Bulk allergens give your practice the ability and convenience to test your patients and interpret results on the spot, without delay. ALK handles the entire manufacturing process from the collection of raw materials, to fi nished allergy extracts. With over one-third of the allergy immunotherapy products worldwide produced by ALK, comprehensive analyses and quality control at all stages of the manufacturing process ensures that our products meet the highest manufacturing and quality standards. ALK is the World Leader in Allergy We are continually developing methodology to examine our extracts for their Purity, Complexity, Potency, and Stability. It is this science-based, extract characterization process that allows us to provide you with information that supports effective diagnosis and treatment. Purity Complexity & # ' " " ( ) & & * " + " ", * Potency! " # $ % Stability -! +. / van Ree, R. J Allergy Clin Immunol Feb; 119(2): Nelson, HS. et al. J Allergy Clin Immunol. 1981; 67:

6 From Farm to Pharma ALK controls the entire manufacturing process - from raw materials collection to packaging and distribution- to ensure quality. Comprehensive analyses and quality control at all stages of the manufacturing process ensure that ALK s products meet the highest manufacturing and quality standards. Raw Material : ; 7 < < = ; > A B? 6 C = 9 > 9? < < = D 6 7 E 7 F 6 G = < A 9 : 7 6 ; B? 6 A 9 A 5 6 = B 7 F 9 = 9 H Production F 6 = 9 > B? > > B = I J 7 < 7 5 J ;? < C? 6 J? K J > > F 6? < L 6 7 A F ; > 9 J 9 6 = L 6 7 A F ; J I < = J > 9 J 9 B = A L 6 7 A F ; > H Finishing M F? < J > N O > 6 7 < J 9? C J >? < D ; K > 7 9 F 6 = L 6 7 A F ; > 9? D = > A ; 9 J 9 > ; N H 2 < < = P > 6? ; > 9? 6 = J 9 B = A B J 5 B < N 6 = 5 F <? > = A ; < E : 8 B J ; B 9 F 6 = 9? Q F? < J > N J 9 B = A L 6 7 A F ; > H Packaging and Distribution ; > 6 7 < 9 > B = < 9 >? 5 = 9 7 D > B = F D? ; > F 6 5 L 6 7 ; = 9 9 R L? ; S? 5 5 : <? I = < 5 : 9 > 7 6? 5 = : 9 B J L L 5 T H 6

7 ALK Extracts 7

8 Extracts Pollens Name Latin Name Acacia Acacia dealbata Alder, White Alnus rhombifolia Alfalfa Medicago sativa Ash, Arizona (Velvet) Fraxinus velutina Ash, White Fraxinus ameriana Aspen, Quaking Populus tremuloides Bahia Grass Paspalum notatum Bayberry Morella cerifera Beech, American Fagus grandifolia Bermuda Cynodon dactylon Birch, Black-Sweet Betula lenta Birch, White Betula verrucosa Box Elder Acer negundo Brome, Smooth Bromus inermis Careless Weed Amaranthus palmeri Cedar, Mountain Juniperus ashei Cedar, Red Juniperus virginiana Cocklebur Xanthium strumarium Cottonwood, Eastern (Common) Populus deltoides spp. monilifera Cottonwood, Western Populus sargentii Cypress, Bald Taxodium distichum Dandelion Taraxacum officinale Dock, Yellow (Curly Dock) Rumex crispus Dock/Sorrel Mix Elm, American Ulmus americana Item # Allergen Type 1:10 w/v ACAC Tree ALDE Tree 1:20 w/v Formulation Glycerin 1:20 w/v ALFA Cul. Crop ARAS Tree 20,000 PNU 40,000 PNU ASH- Tree QUAS Tree BAHI Grass BAYB Tree BEEC Tree BERM Grass BLBI Tree WHBI Tree BOEL Tree BROM Grass CARE Weed MOCE Tree RECE Tree COCK Weed COWO Tree WECO Tree BACY Tree DAND Weed YEDO Weed SODO Weed ELM- Tree Custom products are available, please contact your ALK allergy consultant. Product availability is subject to change without notice. 8 = Indicates outsourced product.

9 Pollens Name Latin Name Elm, Cedar Ulmus crassifolia Elm, Chinese (Siberian) Ulmus pumila Eucalyptus (Blue Gum) Eucalyptus globulus Goldenrod Solidaga canadensis Hackberry Celtis occidentalis Hazelnut, American Corylus californica Hickory, Shagbark Carya ovata Hickory/Pecan Mix Johnson Grass Sorghum halepense Juniper, Western Juniperus occidentalis June (Kentucky Blue) Poa pratensis Kochia (Mexican Firebush) Kochia scoparia Lamb s Quarters Chenopodium album Lenscale Atriplex lentiformis Maple, Red Acer saccharum Maple, Sugar Acer saccharinum Marshelder, Burweed Iva xanthifolia Marshelder, True (Rough) Iva annua Meadow Fescue Festuca pratensis (elatior) Melaleuca Melaleuca quinquenervia Mesquite Prosopis juliflora Mugwort, Common Artemisia vulgaris Mulberry, Red Morus rubra Mulberry, White Morus alba Nettle, Stinging Urtica dioica Oak, Virginia Live Quercus virginiana Oak, White Quercus alba Olive Olea europaea Orchard Dactylis glomerata Item # Allergen Type 1:10 w/v CEEL Tree CHEL Tree EUCA Tree Formulation Glycerin 1:20 w/v GOLD Weed HACK Tree HAZE Tree HICK Tree HIPE Tree 40,000 PNU JOHN Grass WEJU Tree JUNE Grass KOCH Weed LAQU Weed LENS Weed REMA Tree MAPL Tree BUMA Weed ROMA Weed MEFE Grass MELA Tree MESQ Tree MUGW Weed REMU Tree WHMU Tree NETT Weed VILI Tree OAK- Tree OLIV Tree ORCH Grass = Indicates outsourced product

10 Pollens Name Latin Name Palm, Queen Arecastrum romanzoffiana Pecan Pollen Carya illinoinensis Pepper Tree, California Schinus molle Pigweed, Rough Redroot Amaranthus retroflexus Pigweed, Spiny Amaranthus spinosus Pine, Australian (Beefwood) Casuarina equisetifolia Pine, Yellow Pinus echinata Pine, White (Eastern) Pinus strobus Plantain, English Plantago lanceolata Poplar, White Populus alba Privet Ligustrum vulgare Quack Grass Elymus repens Ragweed, False Ambrosia acanthicarpa Ragweed, Short Ambrosia artemisiifolia Ragweed, Giant (Tall) Ambrosia trifida Ragweed, Western Ambrosia psilostachya Ragweed, Mixed Redtop Agrostis alba Russian Thistle Salsola kali Rye, Perennial Lolium perenne Sagebrush, Common Artemisia tridentata Sheep Sorrel Rumex acetosella Sweet Vernal Anthoxanthum odoratum Sweetgum Liquidambar styraciflua Sycamore, American (Eastern) Platanus occidentalis Timothy Phleum pratense Walnut, Black Juglans nigra Willow, Black Salix nigra Item # Allergen Type 1:10 w/v QUPA Tree PEPO Tree Glycerin 1:20 w/v CAPE Tree ROPI Weed SPPI Weed AUPI Tree YEPI Tree WHPI Tree Formulation 10,000 PNU 20,000 PNU 40,000 PNU ENPL Weed POPL Tree PRIV Tree QUGR Grass FARA Weed SHRA Weed TARA Weed WERA Weed MIRA Weed RETO Grass RUTH Weed PERY Grass SAGE Weed SHSO Weed STSV Grass SWGU Tree SYCA Tree TIMO Grass BLWA Tree BLWI Tree Custom products are available, please contact your ALK allergy consultant. 10

11 Molds & Fungi Name (Alternate Name) Alternaria alternata (Alternaria tenuis) Aspergillus fumigatus Aureobasidium pullulans (Pullularia pullulans) Bipolaris sorokiniana (Dreschslera sorokiniana) Botrytis cinerea Candida albicans Cladosporium cladosporioides (Hormodendrum cladosporioides) Epicoccum nigrum (Epicoccum purpurascens) Gibberella pulicaris (Fusarium roseum) Mucor plumbeus Penicillium notatum Rhodotorula mucilaginosa (Rhodotorula rubra) Saccharomyces cerevisiae (Yeast) Sarocladium strictum (Sarocladium strictum) Trichophyton mentagrophytes Item # (1:10 w/v)* Formulation Glycerin (1:20 w/v)* ALTE ASFU AURE BIPO BOTR CAAL CLCL EPIC GIBB MUCO PENO RHOD SACC SARO TRME Mold Mixes Name (Mix Components) Mold Mix A (Alternaria, Aspergillus, Cladosporium, Penicillium) Mold Mix B (Epicoccum, Gibberella, Mucor) Mold Mix C (Botrytis, Candida, Rhodotorula, Trichophyton) Item # (1:10 w/v)* Formulation Glycerin (1:20 w/v)* MOMA MOMB MOMC Smut Formulation Name Latin Name Corn Smut Ustilago maydis Code Allergen Type Glycerin (1:20 w/v)* COSM Smut * The PNU value for aqueous mold extracts and glycerinated mold extracts can be obtained by contacting Customer Service at Custom products are available, please contact your ALK allergy consultant 11

12 Mites Name Latin Name/(Mix Comp.) Item # Acarus siro Allergen Type 1:50 w/v ACSI Mite Formulation 5,000 PNU 10,000 PNU Dust Mite D. farinae Dust Mite D. pteronyssinus Mite, Mixed (D. farinae & D. pteronyssinus) Tyrophagus putrescentiae STDF Mite STDP Mite STMM Mite TPUT Mite Insects Formulation Name Latin Name/(Mix Comp.) Item # Ant, Fire Solenopsis invicta Cockroach, German Blattella germanica Mosquito Culex pipiens Allergen Type 1:10 w/v FIAN Insect Glycerin 1:20 w/v GECO Insect Glycerin 1:100 w/v MOSQ Insect Epidermal & Misc. Formulation Name Latin Name/(Mix Comp.) Item # Cat Hair Felis domesticus Cattle Epithelium Bos taurus Cotton Linters Dog Epithelium Canis lupus familiaris Feather, Mixed (Chicken, Duck, Goose) Guinea Pig Epithelium Cavia porcellus Horse Dander Equus caballus Kapok Allergen Type Glycerin 1:10 w/v Glycerin 1:20 w/v 1:10 w/v 10,000 PNU 20,000 PNU STCH Epidermal COEP Epidermal Misc. DOEP Epidermal MIFE Epidermal GUIN Epidermal HOEP Epidermal KAPO Misc. Mouse Epithelium Mus musculus Rabbit Epithelium Oryctolagus cuniculus Sheep Epithelium Tobacco MOEP Epidermal RABB Epidermal Epidermal Misc. Product availability is subject to change without notice. 12 = Indicates outsourced product.

13 Diagnostic Controls* Item# Description Vial Size Diagnostic DILU15 Control 5 ml Multi-Dose Diagnostic *Contact your ALK allergy consultant for more information Ancillary Items Some Ancillary products are available with different color vial seals (noted below). The last letter of the part number where color options are available determines the seal color. For instance: NSP4020S is NSP 4.0 ml with a Silver seal. Colors available: R = red, Y = gold, G = green, O = orange, P = pink, V = purple, B = blue. Normal Saline with Phenol (NSP) Item# Volume Vial Size Quantity NSP2013S 2.0 ml 13 mm x 16.5 mm 50 NSP2020S 2.0 ml 20 mm x 22 mm 25 NSP4013S 4.0 ml 13 mm x 16.5 mm 50 NSP4020S 4.0 ml 20 mm x 22 mm *Various Colors Available NSP4513S 4.5 ml 13 mm x 16 mm 50 NSP4520S 4.5 ml 20 mm x 22 mm *Various Colors Available NSP8013S 8.0 ml 13 mm x 18.5 mm 50 NSP8020S 8.0 ml 20 mm x 22 mm 25 NSP9020S 9.0 ml 20 mm x 22 mm *Various Colors Available NSP30 30 ml 20 mm x 29 mm (Tall) 1 NSP50 50 ml 20 mm x 40 mm 1 NSP ml 20 mm x 52 mm Labels Item# Description Titration Labels Vial Labels, Roll of 1,000 Blue Vial Labels, Roll of 1,000 Yellow Vial Labels, Roll of 1,000 Green Vial Labels, Roll of 1,000 Red LABELS2 Pump Vials Vial Labels, Roll of 1,000 White Item# Description Quantity ml Glass Amber Vial with 50 ul Metered Pump Amber Vial (for Pump) Dropper Pump.05 ml Black Cap for Amber Vial (with Pump) 1 1 Colored Caps for Vials (13 mm) Item# Color Quantity Dark Blue Green Orange Pink Purple Red Yellow 100 Colored Caps for Vials (20 mm) Item# Color Quantity Dark Blue Green Orange Pink Purple Red Yellow

14 Ancillary Items Sterile Empty Vials (SEV) Item# Volume Vial Size Quantity SEV ml 14 mm x 13 mm 100 SEV513S 5.0 ml 13 mm x 16.5 mm *Various Colors Available SEV520S 5.0 ml 20 mm x 22 mm *Various Colors Available SEV1020S 10.0 ml 20 mm x 22 mm *Various Colors Available SEV20 20 ml 20 mm x 30 mm 1 SEV30 30 ml 20 mm x 36.5 mm 25 SEV50 50 ml 20 mm x 40 mm 25 SEV mL 20 mm x 52 mm SEV Size Chart 2 ml 5 ml 5 ml 10 ml 10 ml 20 ml 30 ml 50 ml 100 ml 14

15 Ancillary Items Syringes Item# Volume Needle Size Description Quantity Manufact Manufact Part # Manufact Packaging SYR ml 27 G x 1/2 Reg. Bevel 1,000 BD trays of 25 SYR ml 27 G x 3/8 ID Bevel 1,000 BD trays of 25 SYR ml 26 G x 1/2 ID Bevel 1,000 BD trays of 25 SYR ml 26 G x 1/2 Reg. Bevel 1,000 BD trays of 25 SYR ml 26 G x 3/8 ID Bevel 1,000 BD trays of 25 SYR ml 27 G x 1/2 Reg. Bevel 1,000 BD trays of 25 SYR ml 27 G x 3/8 ID Bevel 1,000 BD trays of 25 SYR ml 27 G x 3/8 Reg. Bevel 1,000 BD trays of 25 SYR ml 28 G x 1/2 Monoject Perm. Attached Reg. Bevel 1,000 Kendall trays of 25 SYR ml 27 G x 1/2 Non-Saftey Allergy Tray 1,000 SOL-M T 40 trays of 25 SYR ml 23 G x 1/2 Mixing Tray 1,000 SOL-M T 40 trays of 25 *Note - Syringes available may vary and are not exclusive to the types listed above, please call Sales Support for more information. Trays Item# Description Dimensions in inches (L x W x H) Vial Trays for 18 mm and 22 mm base vials, 48 holes (6x8) 10 x 7 3 / 4 x Vial Trays for 18 mm and 22 mm base vials, 60 holes (6x10) 12 x 7 3 / 4 x Rachman Tray, Large #202, 13 mm base vials, 84 holes Rachman Tray, Large #303, 13 mm base vials, 70 holes Rachman Tray, Large #404, 22 mm base vials, 60 holes Rachman Tray, Large #808, 18 holes Lucite Tray, 22 mm base vials, 5-10 ml, 60 holes 11 x 7 x 3 / Syringe Tray (18 places) Rondo Tray, 13 mm base vials, 6 holes Rondo Box Only, 13 mm base vials, 6 holes Rondo Box Only, 13 mm base vials, 10 holes Rachman Tray 808 Rachman Tray 303 Rachman Tray 404 Rachman Tray 202 Vial Trays for 18 mm & 22 mm (48 hole, 60 hole) 15

16 Suggested Diagnostic Zones and Treatment Regions Our Scientific Affairs department has developed these suggested zones and regions by thoroughly reviewing the indigenous allergens of each geographical area. Specific allergens can be ordered separately as needed. If you would like further assistance in developing or modifying your testing panel, please contact our Scientific Affairs department at Northwest Zone Diagnostic Panel Positive Control American Sycamore Mixed Ragweed Johnson Grass Cat Hair Aspergillus Negative Control Eastern Cottonwood Lambs Quarters Bermuda Grass Dog Epithelium Penicillium Queen Palm American Elm Rough Pigweed Red Mulberry Dust Mite (D. farinae) Gibberella Timothy Grass White Ash Sagebrush White Pine Dust Mite (D. pteronyssinus) Aureobasidium Brome Grass Black Walnut Russian Thistle Hackberry Cockroach, American* Bipolaris White Alder Eastern Red Cedar Sheep Sorrel Black Willow Mouse* Rhodotorula Box Elder White Birch Mugwort Rough Marshelder Alternaria Mucor Western Juniper White Oak English Plantain Cocklebur Cladosporium Epicoccum Southwest Zone Diagnostic Panel Positive Control American Sycamore Pecan (pollen) Johnson Grass Cat Hair Aspergillus Negative Control Eastern Cottonwood Mountain Cedar Bahia Grass Dog Epithelium Penicillium Queen Palm American Elm Mixed Ragweed White Alder Dust Mite (D. farinae) Gibberella Perennial Rye Grass White Ash Lambs Quarters Black Willow Dust Mite (D. pteronyssinus) Aureobasidium Bermuda Grass Black Walnut Rough Pigweed English Plantain Cockroach, American* Bipolaris White Oak Mesquite Sagebrush Western Ragweed Mouse* Rhodotorula Box Elder Olive (pollen) Russian Thistle Kochia Alternaria Mucor Western Juniper Red Mulberry Sheep Sorrel Rough Marshelder Cladosporium Epicoccum Southeast Zone Diagnostic Panel Positive Control Red Birch Black Willow White Pine Cat Hair Aspergillus Negative Control Eastern Cottonwood Bayberry American Sycamore Dog Epithelium Penicillium Queen Palm American Elm Mixed Ragweed Yellow Pine Dust Mite (D. farinae) Gibberella Timothy Grass Box Elder Lambs Quarters White Ash Dust Mite (D. pteronyssinus) Aureobasidium Bermuda Grass Pecan (pollen) Rough Pigweed Sweetgum Cockroach, American* Bipolaris Bahia Grass Red Maple English Plantain Red Mulberry Mouse* Rhodotorula Johnson Grass Shagbark Hickory Mugwort Cocklebur Alternaria Mucor White Oak Eastern Red Cedar Sheep Sorrel Rough Marshelder Cladosporium Epicoccum Northeast Zone Diagnostic Panel Positive Control American Sycamore Black Willow Johnson Grass Cat Hair Aspergillus Negative Control Eastern Cottonwood White Pine Privet Dog Epithelium Penicillium Queen Palm American Elm Rough Pigweed Red Mulberry Dust Mite (D. farinae) Gibberella Timothy Grass White Ash Mixed Ragweed Black Walnut Dust Mite (D. pteronyssinus) Aureobasidium Bermuda Grass Shagbark Hickory Lambs Quarters White Pine Cockroach, American* Bipolaris White Birch Red Cedar Sheep Sorrel Russian Thistle Mouse* Rhodotorula Box Elder American Beech Mugwort Rough Marshelder Alternaria Mucor White Oak Red Maple* English Plantain Cocklebur Cladosporium Epicoccum * Only available in Glycerin 16

17 U.S. Pollen Prevalence Northwest Zones Southwest Zones Southeast Zones Northeast Zones Pacific Northwest Central California Coast Gulf Coast Atlantic Northeast Western High Plains Desert Southwest Midwest Mississippi Valley Eastern Mountains Northern Rocky Mountains South Central Texas Subtropical Florida Mid-Atlantic Seaboard Great Plains Midwest Great Lakes Timothy Grass Bermuda Grass Bahia Grass Perennial Rye Grass Brome Grass Johnson Grass White Alder Western Juniper White Oak White Pine Red Birch White Birch Box Elder Red Cedar Eastern Cottonwood White Ash Black Walnut American Elm American Sycamore Shagbark Hickory Mesquite Mountain Cedar Pecan (Pollen) Olive (Pollen) Bayberry Russian Thistle Sheep Sorrel Rough Pigweed Mixed Ragweed Lambs Quarters Sagebrush English Plantain Mugwort Pacific Northwest Western High Plains Northern Rocky Mountains Great Plains Central California Coast Desert Southwest South Central Texas Atlantic Northeast Mid-Atlantic Seaboard Eastern Mountains Midwest Great Lakes Midwest Mississippi Valley Gulf Coast Subtropical Florida 17

18 Cross Reactivity The term cross-reactivity refers to two distinct antigens that are recognized by the same antibody, thereby eliciting a similar immune response. Cross-reactivity in allergic reactions occurs when the proteins in one allergen are similar to the proteins found in other allergen. Typically, cross-reactivity occurs between species in the same taxonomic genus or family. For example: TREES Members of the Betula genus (e.g. White Birch, Red Birch and Black Birch) are cross-reactive. WEEDS Ragweed species (Ambrosia genus) are highly cross-reactive, and exhibit moderate cross-reactivity with other members of the Asteraceae family (e.g Mugwort, Marhshelder, and Cocklebur). GRASSES Timothy grass is expected to be cross-reactive with Pooideae subfamily, including Orchard, Sweet Vernal, and Perennial Rye grasses. MOLDS Molds containing the same genus name (e.g. Aspergillus niger and Aspergillus fumigatus) are considered cross-reactive, and these molds can be readily substituted for one another. ALK strives to improve the scientifi c knowledge base for allergy in the veterinary fi eld. Many cross-reactivity relationships have been established in the scientifi c literature for human immunotherapy, and our Scientifi c Affairs department can provide substitution options available for ALK allergens as well as cross-reactivity charts by request. Our Scientific Affairs Department is available for all of your science questions Science@alk.net Science Hotline: (Option 4) Online helpdesk: 18

19 Weight to Volume Allergenic extracts are available commercially in multiple formulations as well as concentrations. All extracts are initially generated by combining source material (e.g., pollen, mold, etc.) with set volumes of solutions designed to extract allergenic proteins. Weight-to-volume (w/v) is a manufacturer s designation that identifi es the amount of source material and extraction buffer used to make the product. Additionally, w/v extracts may be diluted to a certain Protein Nitrogen Unit (PNU) and sold at specifi c concentrations. Each formulation has unique advantages, and both are successfully utilized for immunotherapy nationwide. In order to determine which formulation is best for your specifi c practice, we have outlined the differences between PNU and w/v extracts below. x y z { } ~ U V W W X Y ˆ X W ƒ V Y Z [ \ ] ^ _ ` a b ` c d e [ f g _ [ d \ g h i j j ] k l ` h c f [ ` a g Š c [ ` c b p c a a [ d i j j f o k Z [ \ ] ^ ` l ` h c f [ ] m ` h h [ n m [ d f o p c a a [ d q r s _ ` q r q t t u v w [ f ` w g h ` a b ` c d e [ f g _ [ d \ g h g n \ f m c d \ _ \ [ b b _ [ d \ h [ Weight-to-Volume (w/v) Most w/v extracts are generated at the 1:10 w/v aqueous strength. This formulation serves as the mother lot from which most other extract formulations are derived. Glycerin extracts may be generated two ways: 1) addition of equal parts of 100% glycerin to the aqueous mother lot, yielding a 1:20 w/v extract; 2) direct extraction using 50% glycerin solutions. The concentration of w/v extracts is typically much higher than diluted PNU formulations, conferring greater protein stability for long-term storage. This equates to more stable potency over the lifespan of the product. Protein Nitrogen Unit (PNU) PNU was one of the fi rst measurements used to describe extract strength and indicates the concentration of total protein in a vial. PNU identifi es the total nitrogen present in a sample measured by the Kjeldahl assay, as specifi ed by the FDA. Nearly all aqueous extracts are subjected to PNU determination as part of FDA-required quality control measures, therefore this measurement is also used to dilute extracts to specifi c PNU concentrations (i.e. 10,000, 20,000, and 40,000 PNU/mL). These dilutions are useful for formulating immunotherapy dosage by PNU. There are a few issues to note when using PNU for immunotherapy applications. Not all of the components identifi ed by the Kjeldahl assay are relevant allergenic proteins, therefore the PNU concentration on the label may overstate the actual amount of true allergen in the vial. To further complicate the issue, studies have shown that in some cases not all of an allergen protein is identifi ed by Kjeldahl assay, causing PNU to understate allergenic content. May et al. reported that only half of the short ragweed in solution was captured by Nitrogen determination 1. Because of this, the FDA does not recognize PNU as a potency measurement and therefore is not a reliable parameter for standardization. Nevertheless, knowledge of PNU concentration does provide some useful information, and is often utilized as a unit for therapeutic dosing. 19

20 Converting between PNU and w/v Extracts Transitioning between PNU and w/v extracts is a relatively straight-forward process, but does require two simple calculations. Before getting started, acquire the PNU value of the w/v extract that will be diluted; identify the desired (diluted) PNU concentration, and determine the total volume of diluted extract that will be created. Most aqueous extracts state the PNU concentration on the vial label. For glycerin extracts or those extracts without a labeled PNU concentration, contact ALK customer service at for the historical PNU concentration. To create a specific PNU concentration from a w/v product: Volume of W/V extract needed = (desired PNU PNU of W/V extract) X Total vial volume Divide the desired PNU concentration by the PNU concentration of the w/v extract; multiply the resulting number by the total volume of diluted extract needed. Example : (10,000PNU/mL desired 80,000PNU/mL w/v extract) X 10mL = 1.25mL of w/v extract needed Next, determine how much diluent is needed to dilute the extract above in a new vial: Volume of diluent needed = Total vial volume Volume of w/v extract needed (determined above) Subtract the volume of w/v extract needed (answer from previous calculation) from the total vial volume that will be created (i.e. 10mL in above example). Example: 10mL 1.25mL = 8.75mL of diluent Finally, use the two numbers from the formulas above to create a diluted extract in a sterile empty vial by combining the w/v extract with diluent *PNU calculators are available, please contact your ALK allergy consultant It is important to note that when the desired PNU concentration is greater than the w/v extract PNU concentration, a dilution cannot be made. For instance, Mountain Cedar 1:10 W/V typically has a PNU concentration below 10,000. Therefore a 20,000PNU/mL vial cannot be formulated. When issues such as these arise, feel free to contact Medical Scientifi c Affairs for advice on extract formulation. ALK Commitment ALK is committed to helping our customers maintain uniformity of care for their patients. Please do not hesitate to contact Scientifi c Affairs Team at should you have additional questions or concerns regarding a transition between ALK products. References 1. May, et.al JACI 63:89 (1979) 20

21 Ordering Information Terms and Conditions Confirmation A confirmation number will be issued for all telephone orders. Fax and orders will be confirmed by the corresponding method within 24 hours. If you send a written confirmation of your telephone order, you must indicate Confirming Phone Order to prevent duplication of your order. No credit will be issued for duplication resulting from customer errors in ordering. Shipping To provide the best service and to safeguard the integrity of our products, allergen extracts are shipped to arrive the next day. Allergenic extracts are normally shipped Monday, Tuesday, Wednesday and Thursday only to avoid weekend delays. Other products are shipped daily by ground delivery service. Freight charges are calculated by weight of package rounded to the nearest full pound. Terms F.O.B. Round Rock, TX or Port Washington, NY. Net 30 days. All prices are subject to change without notice. Return Policy Please contact Sales Support at for all product return and/or credit issues. Allergenic extracts and sterile products may not be returned unless shipped by an ALK, Inc. error. All shipping errors must be reported to Sales Support within 10 days of invoice date. Returns are permitted ONLY with prior authorization from the Sales Support Department. If, for any reason you are dissatisfied with the quality of the product, these returns will not be subject to the stated 10-day time period, but will be subject to our investigation and approval process. Product return requests initiated in response to customer order errors will be subject to a 15% processing charge, provided that the item is eligible for restocking per the ALK, Inc. Restocking Policy. Per the Restocking Policy, we are not able to restock allergy extracts. You will be notified as to the results of all return investigations within 5 10 business days. Upon investigation and approval of your return claim, a credit will be issued to your account and/ or replacement product will be shipped to you, when deemed necessary. A revised invoice will not be sent; however, a copy of the credit memo will be sent and/or faxed to the number or address on record. Product Quality If you have any concerns with product quality, please contact our Sales Support department at. The 10-day call limitation does not apply to product quality issues, but will be subject to our investigation and approval process. Errors Errors in order entry or shipping should be reported immediately but no later than ten (10) days from date shipped (invoice date). Minimum Order A minimum order of $50 is required. Please combine orders to achieve these minimums. A service charge of not more than $10 will be applied to orders of less than $50. 21

22 Œ Ž Ž š œ ž Ÿ ž š ž ž ª ª «ª ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ² ³ µ µ µ µ ³ µ ¹ º µ µ» ¼ ³ ½ µ ¹ ¾ µ º À ³ Á  à ¾ Ä µ  µ À Á º Ä ½» µ» µ À Á Å Æ À º Æ ¼ ³ ½ Å ³ ½ Ä» Ä À Ç µ ³ µ º µ À È µ ¾ ³» ½ º  À Á ¼ ³ ½ ³ É É À º µ Ê Ë Ä µ  µ Á ³ µ Ã Å Æ µ Á É ¹ À Á Ì Ã µ Í ½ µ  µ»» µ Ä À È µ ¼» µ ½  µ À Á À ½ ³ É Î Ï Æ ³ ½  ³ ½ É ³ Æ µ À µ ³» µ À  µ º µ À È µ» ¼ Ð Ñ Ò Ê Ó É ¾ ³» ½ º  µ Á µ µ» µ» ½ Ì µ Á Ä ¼ Ô Å À Æ À Á Î Ï Æ ³ ½ Â Õ À À  µ  ³ º Ä Ä ³ ½ Ö ½  ³ µ µ È À º µ» µ ¾ µ Á É ³ ¾ µ  ³ Á Ä À Ø µ» ³» µ ¾ Ä º µ µ Á Ê Ù ¹ º  µ Á ³ Ä Ä ¼ Â Æ À ¾ ¾ µ» ³ È µ Á À Ì Æ Á» Ð Á º À Ä Ä ¼ À µ Â Ô È À Ä Â Ã» À Ä ½ µ Á  à  ¼ À Á Ì µ Â Õ µ  µ Á È À Ì ³ ½ Á»» µ Ä À È µ ¼ Ô Ì µ Á µ Ä Ä ¼ Ú Û Ü ½  À Á µ  » ¼ Â É ³ Â Æ À ¾ ¾ À Á Ì» µ Õ Ê Ý Þ «ß Þ à ß ª á â ã ± ± ± ± ± ± ± ± ± ± ± ± ± ± Þ ä å â æ ç ã è ß æ é ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± Þ æ ê â á ë â Ý ã è å æ ê ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± Ý ì æ ê ã ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± í á î ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± Ý é à é ß ä ç ï ã è ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ð ñ ò ò æ ì ñ ó æ á ç ã á å ð ñ ò ò æ ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô ô õ ö ø ö ù ú û ù ü ý þ ø ÿ ö ø ø ü ø ù ý ý ù ö þ ö ø õ ý ü ý þ ø û ä ã æ ä å «ò ë ã è ñ ê Þ «Þ ã ê â ã è ò Þ ë è á â ë ì ª ê â è á ã è ç á ò ß à ì ã ê æ è ã è ñ ê ê æ ê å â æ ë ó ã ë ñ á ò ñ î â ä è ã å ó ò ã á å ã ò ñ å â â ì ã Þ í ê ä ç ï ã è á ê «æ â ê ä ç ï ã è Ë Ä µ  µ Ö Æ µ º Ç Ð Ä Ä ² Æ Ð ¾ ¾ Ä À µ Â Ó Á È ³ À º µ Ð º º ³ ½ Á À   µ Ö» Ð µ À º Á Ù ¹ ¾ µ   À  º ³ È µ Þ á è ß æ ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± Þ á è ì æ ò ã è ß á ç ã ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± î ó ± ± ± ± ± ± ± ± ± ± ± ±! " # $ % & & ' $ " $ ( ) %! * +! ) " 22, -. / / : : ; < = 6 5 < >? ; < 3 > 1 ; < A C D 9 E F F G H E F F I J K K I 9 9 J J L M

23 ACTT Allergy Program 23

24 ALK and the ACTT Allergy Program ALK enables the veterinary dermatologist and general practitioner alike to manage allergic patients with confi dence and success. We provide complete allergy management, offering allergy testing and treatment solutions that suit the needs of your patients and your practice. Our commitment is to help you bring allergy relief to your patients, and to provide you with the resources to grow your allergy practice. Allergenic Extracts ALK handles the entire manufacturing process from the collection of raw materials to fi nished allergy extracts ALK provides over one-third of the allergy immunotherapy products worldwide Comprehensive analyses and quality control at all stages of the manufacturing process In addition to providing allergenic extracts, ALK also provides the ACTT Allergy Program, with serum allergy testing and custom -made, allergen specifi c treatment. ACTT Allergy Test Supplement for skin testing In vitro serum IgE testing for allergen identifi cation No steroid or antihistamine interference Accurate and reproducible results Canine, feline, and equine Comprehensive: weeds, trees, grasses, molds, mites, insects, foods, fl eas, and culicoides. ACTT also offers testing for Staphylococcus and Malassezia. Patient Specific Treatment Sets Customized treatment sets based on your dosing and formulation protocols in both subcutaneous and sublingual ACTT formulations available following fi ve different protocols; specifi c to the patient s species, age, weight, breed and clinical history USDA approved sublingual treatments Strict quality control and sterility standards in production Allergy Program Countless Pet Allergies. One Solution. 24

25 ACTT Serum Testing ACTT Allergy Test Proven Technology The ACTT ELISA technology identifi es allergen-specifi c IgE with precision and accuracy. Our affi nity purifi ed, anti-ige antibody detects IgE only; it does not bind to IgG. Test scores are not subject to miss-identifi cation or false-positive due to IgG interference. Our laboratory employs rigorous quality control methods to ensure accurate and reproducible test results for each patient. No Steroid Interference ACTT Allergy Test results are not affected by steroid use. Your patient does not need to be withdrawn from steroid or anti-histamine therapy prior to serum allergy testing, making this modality a safe and accurate testing alternative to intradermal testing. ACTT Allergy Testing Services Successful allergy management begins by identifying all aspects of the animal s allergy exposure. The ACTT Allergy Test offers a comprehensive list of testing options: The ACTT ELISA test results are the foundation for a successful immunotherapy treatment program. Immunotherapy is the only treatment that can change the course of allergic disease, and is a safe, all- natural treatment modality. Immunotherapy is available in allergy shots and allergy drops. 25

26 ACTT Treatment Allergen-Specific Immunotherapy Treatment Immunotherapy is the only allergy treatment that actually reverses the natural course of allergic disease, thereby reducing the body s sensitivity to allergens. Because every allergy case is unique, we custom-formulate treatment for each animal, based on species, age, weight, breed and clinical history. This unique feature separates ALK from other laboratories. Benefi ts of custom treatment include: Fewer patient reactions to injections and drops Quicker improvement of the patient s symptoms Increased owner compliance Distinguishing Features of ACTT Immunotherapy Careful Allergen Selection ALK focuses on treating immuno-dominant allergens, which provide cross protection for any allergens in related families. Allergen cross-reactivity occurs within grass, tree, weed, mold, dust mite and insect families. Separation of Molds, Mites and Insects ALK follows the recommendations of the AAAAI for allergen groupings when formulating immunotherapy treatment. Custom Treatment Protocols Immunotherapy protocols are custom-formulated according to the species, age, weight, breed and clinical history of each animal. Save staff resources, minimize inventory, and reduce necessary mixing space - ALK can customize your treatment sets. For more information about testing and treatment, please call to speak with our allergy specialists. 26

27

28 Visit Us Online Order Online 24 hours a day. myalkus.com Orders customerservices@alk.net Telephone Orders 7:30 am - 5:30 pm CST Mon-Wed 7:30 am - 5:00 pm CST Thurs - Fri Serum Testing and Treatment Telephone Orders Fax Orders ALK USA 1700 Royston Ln Round Rock, TX ALK products are available to licensed veterinarians only. 28 VET-US