PROTHIOCONAZOLE (232) First draft prepared by Mr D. Lunn, Senior Programme Manager, New Zealand Food Safety Authority, Wellington, New Zealand

Transcription

1 Prothioconazole 883 PROTHIOCONAZOLE (232) First draft prepared by Mr D. Lunn, Senior Programme Manager, New Zealand Food Safety Authority, Wellington, New Zealand EXPLANATION Prothioconazole was evaluated for the first time by the 2008 JMPR, which recommended maximum residue limits for peanut, rape seed, barley, oats, rye, triticale and wheat grain and straws, and for meat, mammalian fats and milks based on a residue definition of prothioconazole. At the 41 st Session of the CCPR, the Delegation of the expressed concern that because JMPR had adopted this residue definition, all US field trial data which reported only total residue (i.e., the sum of prothioconazole and desthio-prothioconazole) had been disregarded, even though residues of the parent compound, prothioconazole was a very small part of the total residue. The CCPR noted this concern and requested JMPR to review the existing US data (together with any additional residue information) on pulses, sugar beet, cereal grains (wheat, barley), canola (rape seed), soya bean, and cereal forages/straws. The present meeting was provided with additional information on residues of the sulfonic acid and desthio metabolites of prothioconazole that were analysed seperately in the above US/Canadian field trials (but initially summed and reported as total prothioconazole residues). USE PATTERN Information provided to the JMPR 2008 meeting on registered uses for prothioconazole on the crops under reconsideration, are summarised in the following tables. Table 1 Use pattern of prothioconazole for foliar application with spraying in cereals in, [See 2008 JMPR Evaluations, Prothioconazole, Table 4] Crop Form (conc) a Rate (max) (kg ai/ha) litres/ha No b Barley SC (480) (GS/days) Barley United States SC (480) c Up to 5d after full head emergence Max 330 g ai/ha/year d interval Wheat SC (480) Spring, durum & winter wheat Wheat United States SC (480) c Up to full flower (Feekes 10.52). Max 330 g ai/ha/year d interval a concentration expressed as g ai/litre b Maximum rate/ha/year requires at least 1 application at less than the maximum rate/ha c Minimum. Harvest interval based on last application at full head emergence (barley) or full flowering (wheat) growth stages Note: s of 5 days for wheat forage and 12 days for wheat and barley hay used by US EPA for establishing MRLs in these commodities. Notes

2 884 Prothioconazole Table 2 Use pattern of prothioconazole for foliar application in pulses, canola, rape and sugarbeet in, [See 2008 JMPR Evaluations, Prothioconazole, Tables 48 49] Crop Form (conc) a Rate (kg ai/ha) Water rate (L/ha) No. Notes Canola SC (480) b Incl rapeseed, Oriental mustard Apply at 20-50% bloom Canola SC (480) b d interval up to 50% bloom Max 400 g ai/ha/year Chick pea SC (480) d intervals Chick pea SC (480) d intervals Max 600 g ai/ha/year Lentils SC (480) d intervals Lentils SC (480) d intervals Max 600 g ai/ha/year Peanut SC (3) d intervals With tebuconazole (28) Not for animal feed or grazing Peanut SC (480) d intervals Max 800 g ai/ha/year Not for animal feed or grazing Peas & beans (dried, shelled) SC (480) day intervals Max 600 g ai/ha/year Includes Lupinus, Phaseolus, Vigna, Pisum spp, dry broad, guar & lablab beans Rape SC (480) b d interval up to 50% bloom Max 400 g ai/ha/year Also Indian rape, Field mustard, Crambe Soya bean SC (480) min 3 21 Aerial: 4 L/ha min d intervals Max 315 g ai/ha/year Sugar beet SC (480) d intervals Max 600 g ai/ha/year Sugar beet SC (480) 0.2 Soil-borne diseases: Band spray (180mm) before row closure a concentration expressed as g ai/litre b Minimum of 36 days. Harvest interval based on last application at 50% bloom growth stage RESIDUES RESULTING FROM SUPERVISED TRIALS ON CROPS The 2008 JMPR meeting received supervised trial data for prothioconazole uses on barley, wheat, triticale (one seed dressing trial), dried bean and pea, oil seed rape and canola, sugar beet, soya bean and peanut. Prothioconazole was applied as a foliar spray using an EC (emulsifiable concentrate), SC (suspension concentrate) formulation, and for seed dressing of cereals using a FS (flowable concentrate) formulation. The use patterns permit both uses on cereals. The present meeting received further information on the individual residue components measured in the trials from and on pulses (dried beans and peas), soya beans, sugar beet, wheat, barley, rape seed and peanut and these new data are summarised in the following tables (taken

3 Prothioconazole 885 from the 2008 JMPR Evaluation of prothioconazole). In these tables, results have been rounded to 2 significant figures, or one significant figure when the results are close to the Limit of Quantification. Commodity Table Beans, dry (beans), Table 3 Peas, dry (peas), Table 4 Soya bean (beans) Table 5 Sugar beet (roots) Table 6 Wheat (grain), Table Barley (grain), Table 8 Oil seed rape (seeds), Table 9 Peanut (meat) Table 10 Sugar beet (tops) Table 11 Wheat (forage), Table 12 Wheat fodder (hay, straw), Table 13 Barley fodder (hay, straw), Table Soya bean (forage) Table 15 Soya bean (hay) Table 16 Peanut (hay) Table 1 Pulses (beans, dry and peas, dry) The 2008 JMPR reported that a total of 22 trials on peas, dry and beans, dry were carried out with 3 foliar application of SC480 formulation at a target rate of 200 g/ha in (9) and (13). The interval between applications was 9 to days. Mature (dry) seeds (BBCH 89 to 92) were harvested to 8 days after the last treatment. As a part of normal agricultural practice, plants were cut and allowed to dry in the field for 2 to 8 days prior to collecting the dried seeds. The pre-harvest interval () for the dried peas and beans is based on the date when the dried peas and beans were cut. Residues of prothioconazole, desthio-prothioconazole and prothioconazole sulfonic acid were analysed using Method RPA JA/03/01 which extracts residues of the desthio metabolite unchanged, converts prothioconazole residues to a mixture of the sulfonic acid and desthio metabolites and measures these two components seperately using LC/MS-MS. The reported limit of quantification for this method is 0.05 mg/kg for both components. Tables 3 and 4 summarise the results of these trials, initially reported in the 2008 JMPR Evaluation (Prothioconazole Table 52), with the inclusion of the additional information on reported residues of prothioconazole sulfonic acid and desthio-prothioconazole [BCS ].

4 886 Prothioconazole Table 3 Residues in beans, dry from residue trials conducted with three foliar applications of prothioconazole (480 SC) on beans in North America. BEANS, DRY (Variety) kg ai/ha kg Lentil () Chickpea () Dried & shelled peas & beans () Bean (OAC Thunder) Lynden, Ontario Bean (Othello) Fromberg, Montana Bean (Pinto Othello) Taber, Alberta Bean (Pinto Othello) Ephrata, Washington Bean (Pinto) Carlyle, Illinois Bean (Pinto) Plainview, Texas Bean (Pinto) Stilwell, Kansas Bean (Red Kidney) Fresno, California Bean (Remington) Eldridge, N Dakota Bean (Sanilac) Oxford, Indiana Residues (mg/kg) in dry beans Max 0.6 kg ai/ha/year J H , , , J602-02H , , J H J H J H J H , , 0.08, 0.16, , 0.05 J D 0.09, J H J H J H

5 Prothioconazole 88 Table 4 Residues in peas, dry from residue trials conducted with three foliar applications of prothioconazole ( SC) on peas in North America PEAS, DRY (Variety) kg ai/ha kg Lentil () Chickpea () Dried & shelled peas & beans () Pea, field (Carnival) Campbell, Minnesota Pea, field (Delta) Rosthern, Saskatchewan Pea, field (Delta) Wakaw, Saskatchewan Pea, field (DS Admiral) Brookdale, Manitoba Pea, field (Eiffel) Edmonton, Alberta Pea, field (Eiffel) Kipp, Alberta Pea, field (Keoma) Rosthern, Saskatchewan Pea, field (Majorettes) Hermiston, Oregon Pea, field (Sugar Snap) Hood River, Oregon Pea, field (Talbot) Jerome, Idaho Pea, field (Tonic) Ephrata, Washington Residues (mg/kg) in dry peas Max 0.6 kg ai/ha/year J H , , , J H 0.16, , , J601-02H J H , , , ,, , , 0.06, ,, J D, J60-02H J H J H , , , , , , , , , , J D 0.09, , J H 0.11, , J600-02H

6 888 Prothioconazole PEAS, DRY (Variety) Pea, field (Trapper) Branchton Ontario Pea, field (XP ) Madras, Oregon kg ai/ha kg Residues (mg/kg) in dry peas J H J H Soya bean The 2008 JMPR reported that in trials conducted in, 3 foliar spray applications of JAU SC were made to soya beans at a target rate of 150 g/ha/application (actual ranged from 5 to 188 g/ha) using spray volumes ranging from 85 to 18 L/ha. Intervals between applications were from to 11 days. All applications were made using ground-based equipment. A non-ionic surfactant was added as a spray adjuvant at the lowest labelled rate. Duplicate treated samples of soya bean forage and hay were collected at s ranging from 5 to days and seed was collected at s ranging from 19 to 23 days. Residues of prothioconazole, desthio-prothioconazole and prothioconazole sulfonic acid were analysed using Method RPA JA/03/01 which extracts residues of the desthio metabolite unchanged, converts prothioconazole residues to a mixture of the sulfonic acid and desthio metabolites and measures these two components seperately using LC/MS-MS. The reported limit of quantification for this method is 0.05 mg/kg for both components in soya bean seed, forage and hay. Table 5 summarises the results of these trials, initially reported in the 2008 JMPR Evaluation (Prothioconazole Table 65), with the inclusion of the additional information on residues of prothioconazole sulfonic acid and desthio-prothioconazole [BCS ]. Table 5 Residues in soya bean seed from residue trials conducted with three foliar applications of prothioconazole ( SC) on soya beans in SOYA BEAN (Variety) kg ai/ha kg Residues (mg/kg) in soya bean seed Soya bean () 3 x Min 0 L/ha (ground), 4 L/ha (air) Max kg ai/ha/year Soya (Pioneer 96M20) Molino, Florida GS ,,,,, SC 480 (JMPR08) RAJAY026 JA0-04D-P2

7 Prothioconazole 889 SOYA BEAN (Variety) Soya (Stine 288) Seymour, Illinois Soya (Pioneer RR 9B52) Tifton, Georgia Soya (Pioneer 9492RR) Leland, Mississippi Soya (DP 5915 RR) Washington, Louisiana Soya (DP5634RR) Proctor, Arkansas Soya (Fontanelle 431RR) Stilwell, Kansas Soya (NKS28W2) Springfield, Nebraska Soya (Croplan RT090) Britton, South Dakota Soya (Croplan RT4) Dumfries, Minnesota Soya (SC 933) New Holland, Ohio Soya (92M0) Bagley, Iowa kg ai/ha kg Residues (mg/kg) in soya bean seed GS ,,,,, GS80 21, GS9 20, GS81 21, RAJAY026 JA019-04D-P2 RAJAY026 JA015-04H-P2, RAJAY026 JA016-04H-P2 RAJAY026 JA01-04H-P2 GS , 0.06, RAJAY026 JA018-04H GS8 23, 0.06, 0.0 RAJAY026 JA020-04H GS80 19, GS83 19, GS9 21, RAJAY026 JA021-04H-P2 RAJAY026 JA024-04H-P2 RAJAY026 JA025-04H-P2 GS , , 0.1 RAJAY026 JA026-04H GS9 19, RAJAY026 JA02-04H-P2

8 890 Prothioconazole SOYA BEAN (Variety) Soya (DynaGro DG 32M32RR) York, Nebraska Soya (Pioneer RR) Sheridan, Indiana Soya (Pioneer 93M80) Richland, Iowa Soya (Pioneer 91M50) Geneva, Minnesota Soya (Pioneer 93B85) Geneva, Minnesota Soya (BT-383CR) Carlyle, Illinois Soya (RG 200 RR) Sabin, Minnesota 2005 kg ai/ha kg GS: growth stage at last application Residues (mg/kg) in soya bean seed GS80 19, GS9 21, GS83 21, GS80 20, GS 21, GS9 21, GS69 19, RAJAY026 JA028-04H-P2 RAJAY026 JA029-04H RAJAY026 JA030-04H-P2 RAJAY026 JA031-04H-P2 RAJAY026 JA032-04H-P2 RAJAY026 JA033-04H RAJAY026 JA022-04HA Sugar beet The 2008 Meeting received reports of 12 residue trials on sugar beet from complying with US GAP. In these trials, three foliar spray applications of JAU SC were made to sugar beets at a target rate of 200 g/ha/application (actual ranged from 192 to 2 g/ha) using spray volumes ranging from 85 to 18 L/ha. Intervals between applications were from 8 to 10 days. A non-ionic surfactant (NIS) was added as a spray adjuvant at the lowest labelled rate. All applications were made using ground-based equipment. Sugar beet tops and roots were harvested when the beets had reached harvestable size (BBCH 49). Sampling was performed at 6 - and 13 - days after last treatment. Residues of JAU646, JAU646 and JAU were measured. In these trials, residues of prothioconazole, desthio-prothioconazole and prothioconazole sulfonic acid were analysed using Method RPA JA/03/01 which extracts residues of the desthio metabolite unchanged, converts prothioconazole residues to a mixture of the sulfonic acid and desthio metabolites and measures these two components seperately using LC/MS-MS. The reported limit of quantification for this method is 0.05 mg/kg for both components in sugar beet roots and tops. Table 6 summarises the results of these trials, initially reported in the 2008 JMPR Evaluation (Prothioconazole Table 53), with the inclusion of the additional information on residues of prothioconazole sulfonic acid and desthio-prothioconazole [BCS ].

9 Prothioconazole 891 Table 6 Residues in sugar beet roots from trials conducted with three foliar applications of prothioconazole (JAU SC) on sugar beet in SUGAR BEET (Variety) kg ai/ha kg Residues (mg/kg) in sugar beet roots Sugar beet () Max 0.6 kg ai/ha/year Sugar beet (unknown) Springfield, Nebraska Sugar beet (Tonic) Sabin, Minnesota Sugar beet (Talbot) Rockwood, Ontario Sugar beet (Hilleshog 2433RZ) Britton, South Dakota Sugar beet (66283 Medium) Theilman, Minnesota Sugar beet (Crystal 955) Velva, North Dakota Sugar beet (Wrangler) Levelland, Texas Sugar beet (Beta 85 LL) Jerome, Idaho Sugar beet (Beta 4430R) Porterville, California Sugar beet (Alpine) Fresno, California Sugar beet (Beta 4490R) Rupert, Idaho Sugar beet (Beta 4490R) Twin Falls, Idaho , , , 0.06, 0.05, 0.09, , , , , , ,, 0.0, , , , , , JA001-04D M JA002-04H M JA003-04H M JA004-04H M JA005-04H M JA006-04H M JA00-04H M JA008-04H M JA009-04H M JA010-04H M JA011-04H M JA012-04H M

10 892 Prothioconazole Cereal grains The 2008 JMPR reported that in and, a total of 54 residue trials (52 harvest and 2 decline) were conducted on wheat with the 480 SC formulation of prothioconazole. Two foliar spray applications of JAU SC were made (±2) days apart to each treated plot at a target rate of 12 g ai/ha (120 3 g ai/ha) for the first application made at BBCH growth stage 34 to 65 ( Node 4 at least 2 cm above node 2 to full flowering: 50% of anthers mature ) and 202 g ai/ha ( g ai/ha) for the second application made at BBCH growth stage 59 to 1 ( end of heading; inflorescence fully emerged to first grains have reached half their final size ) in target spray volumes ranging from 103 to 421 L/ha. The interval between applications was 13 to 18 days. Residues of desthio-prothioconazole and prothioconazole sulfonic acid in forage, hay, grain and straw were determined after 2 spray applications were analysed using Method RPA JA/03/01 which extracts residues of the desthio metabolite unchanged, converts prothioconazole residues to a mixture of the sulfonic acid and desthio metabolites and measures these two components seperately using LC/MS-MS. The reported limits of quantification for both residue componemts are 0.02 mg/kg in grain and 0.05 mg/kg in forage, hay and straw. From the treated plot of each trial, duplicate composite samples of forage, hay, grain, or straw were collected. Both residue values are reported for each of the matrices, however only the larger ones were taken into account for estimation of maximum residue levels. Wheat Table summarises the results in wheat grain from these trials, initially reported in the 2008 JMPR Evaluation (Prothioconazole Tables 1 and 2), with the inclusion of the additional information on residues of prothioconazole sulfonic acid and desthio-prothioconazole [BCS ]. Table Residues in wheat grain from trials conducted with two foliar applications of prothioconazole (JAU SC) on wheat in North America WHEAT (Variety) kg ai/ha kg Residues (mg/kg) in wheat grain Wheat () SC 480 Wheat () 1+1 a Maximum 0.33 kg ai/ha/year SC 480 Wheat (Russ Wheat) New Rockford, N Dakota Wheat (Arapahoe) Louisville, Nebraska Wheat (Tahoe) St. George, Ontario ,,,,,,,,,,,,,,,,,,,,,,,, 42,,, J D J D J H

11 Prothioconazole 893 WHEAT (Variety) Wheat (Penawawa) Hermiston, Oregon 200 Wheat (Ogallala) Uvalde, Texas Wheat (Jagger) Claude, Texas Wheat (Custer) Cordell, Oklahoma Wheat (Custer) Frederick, Oklahoma Wheat (Tam 200) Hart, Texas Wheat (235) Velva, North Dakota Wheat (Tam 202, Lot Star 10) Levelland, Texas Wheat (Alsen) Ellendale, North Dakota Wheat (Forge spring wheat) Lake Andes, S Dakota Wheat (Tahoe) Paris, Ontario Wheat (Mit) East Bernard, Texas Wheat (Karl 92) Stilwell, Kansas kg ai/ha kg Residues (mg/kg) in wheat grain 42,,, 42,,, 41,,, 38,,, 40,,, 35,,, 33,,, 43,,, 39,,, J604-00H J H J H J H J H J H J H J H J H 46,, 0.022, 0.03 J H 42,,, 32,,, 42,,, J605-00H J H J H

12 894 Prothioconazole WHEAT (Variety) Wheat (Becks 10) Oxford, Indiana Wheat (Barrie) Red Deer, Alberta Wheat (HRS wheat prodigy) Monarch, Alberta Wheat (Pioneer 2684) Benoit, Mississippi Wheat (Cooker 10) Knightdale, N Carolina Wheat (AC Cora) Minto, Manitoba Wheat (AC Cora) Minto, Manitoba Wheat (AC Barrie) Wakaw, Saskatchewan Wheat (McKenzie) Leask, Saskatchewan Wheat (AC Cadillac) Rostern, Saskatchewan Wheat (Barrie) Brookdale, Manitoba Wheat (Barrie) Lacombe, Alberta Wheat (AC Barrie) Delisle, Saskatchewan kg ai/ha kg Residues (mg/kg) in wheat grain 43,,, 5,,, J H J H 30, 0.04, , 0.04 J H 42,,, 3,,, 4,,, 49,,, 55,,, 48,,, 53,,, J H J H J H J606-00H J H J H J600-00H 43, 0.02, , 0.04 J601-00H 5,,, 38,,, J602-00H J603-00H

13 Prothioconazole 895 WHEAT (Variety) Wheat (Prodigy) Delisle, Saskatchewan Wheat (HRS wheat prodigy) Warner, Alberta Wheat (Prodigy) Coaldale, Alberta Wheat (Prodigy) Kipp, Alberta kg ai/ha kg Residues (mg/kg) in wheat grain 43,,, J604-00H 31, 0.025, , 0.04 J605-00H 35,, 0.02, 0.02 J606-00H 30, 0.02, , 0.06 J60-00H a Maximum rate/ha/year requires at least 1 application at less than the maximum rate/ha Barley The 2008 JMPR received a total of 25 residue trials (23 harvest and 2 decline) conducted with two foliar applications with 480 SC formulation of prothioconazole on barley and. The first application rate was made at growth stage of BBCH 45 to 4 at a target rate of 123 g a.s/ha (120 3 g ai/ha) using spray volumes ranging from 18 to 468 L/ha. The second application was made at full flowering BBCH 65 (±2 days) at a target rate of 202 g a.i/ha ( g ai/ha) using spray volumes ranging from 18 to 468 L/ha. The interval between applications was 5 to 2 days. Residues of desthio-prothioconazole and prothioconazole sulfonic acid in hay, grain and straw were determined after 2 spray applications were analysed using Method RPA JA/03/01 which extracts residues of the desthio metabolite unchanged, converts prothioconazole residues to a mixture of the sulfonic acid and desthio metabolites and measures these two components seperately using LC/MS-MS. The reported limits of quantification for both residue componemts are 0.02 mg/kg in grain and 0.05 mg/kg in hay and straw. From the treated plot of each trial, duplicate composite samples of barley hay, grain, or straw were collected. Both residue values are reported for each of the matrices, however only the larger ones were taken into account for estimation of maximum residue levels. Table 8 summarises the results in barley grain from these trials, initially reported in the 2008 JMPR Evaluation (Prothioconazole Table 3), with the inclusion of the additional information on residues of prothioconazole sulfonic acid and desthio-prothioconazole [BCS ]. Table 8 Residues in barley grain from trials conducted with two foliar applications of prothioconazole (JAU SC) on barley in North America BARLEY (Variety) kg ai/ha kg Residues (mg/kg) in barley grain Barley () SC 480 Barley () 1+1 a Maximum 0.33 kg ai/ha/year SC 480

14 896 Prothioconazole BARLEY (Variety) Barley (Robust) Northwood, N Dakota Barley (Chapais) Branchton, Ontario Barley (Steptoe) Hermiston, Oregon Barley (Baretta) Maricopa, Arizona Barley (Baretta) Wilcox, Arizona Barley (Robust) Velva, North Dakota Barley (Robust) New Rockford, N Dakota, Barley (Robust) Ellendale, North Dakota, Barley (Morex) Jerome, Idaho Barley (Robust) Northwood, N Dakota Barley (AC Stephen) Germans-ville, PA Barley (Robust) Minto, Manitoba Barley (Robust) Minto, Manitoba Barley (AC Rosser) Brookdale, Manitoba kg ai/ha kg Residues (mg/kg) in barley grain,,,,,,,, 0.03, , , 0.04, , 0.03, , , 0.04, , , 0.05, , , , , 0.02 J D J D 42,,, J H , , , 0.08 J H 1, , , 0.08 J H 33,,, J H 36, 0.02, , 0.04 J H 43,,, J600-00H 43,,, J H 44, 0.02, , 0.03 J H 5,, 0.02, J H , , , 0.13 J608-00H , , , 0.16 J609-00H , 0.03, , 0.06 J H

15 Prothioconazole 89 BARLEY (Variety) Barley (Bedford) Clanwilliam, Manitoba, Barley (AC Metcalf) Marcelin, Saskatchewan, Barley (Harrington) Rosthem, Saskatchewan, Barley (Harrington) Wakaw, Saskatchewan, Barley Lacombe, Alberta Barley Penhold, Alberta Barley (Stein) Rosthem, Saskatchewan, Barley (AC Harper) Kipp, Alberta, Barley (Lacombe) Leduc, Alberta, Barley (Excel) Delisle, Saskatchewan Barley (Chapais) St-Paul-d'Abbotsford, Quebec, kg ai/ha kg Residues (mg/kg) in barley grain 65,, , 0.03 J H 48,,, J H 43,,, J H 34,,, J H 1 J H 1,,, J H 52,,, J608-00H 4,,, J H 33,,, 0.02 J H 30, , , 0.09 J H 36, , , 0.11 J H a Maximum rate/ha/year requires at least 1 application at less than the maximum rate/ha Rape seed The 2008 JMPR received the results from North-American trials on oil seed rape (canola) where two foliar spray applications of JAU SC were made at a target rate of 202 g/ha/application (actual ranged from 190 to 213 g/ha) using spray volumes ranging from 150 to 384 L/ha. All applications were made using ground-based equipment. The first application was made at BBCH 51 to 53 (flower buds visible to flower buds raised above the youngest leaves), and the second application was made at BBCH 65± 2 days (full flowering). The interval between applications was

16 898 Prothioconazole to 44 days. Canola seed was harvested from the treated plots at earliest commercial harvest ( BBCH growth stage 83) which ranged from 36 to 83 days after the last treatment. Residues of desthio-prothioconazole and prothioconazole sulfonic acid in rape seed were analysed using Method RPA JA/03/01 which extracts residues of the desthio metabolite unchanged, converts prothioconazole residues to a mixture of the sulfonic acid and desthio metabolites and measures these two components seperately using LC/MS-MS. The reported limit of quantification for both residue components are 0.02 mg/kg in rape seed. Table 9 summarises the results in rape seed from these trials, initially reported in the 2008 JMPR Evaluation (Prothioconazole Table 63), with the inclusion of the additional information on residues of prothioconazole sulfonic acid and desthio-prothioconazole [BCS ]. Table 9 Residues in rape seed from trials conducted with two foliar applications of prothioconazole (JAU SC) on oil seed rape (canola) in North America OIL SEED RAPE (Var) kg ai/ha kg Residues (mg/kg) in rape seed Canola () day spray intervals Canola () Rape () Incl Indian rape Rape (Phoenix) Jerome, Idaho Rape (Invigor 243L) Branchton, Ontario Rape (Quest) Bethany, Manitoba Rape (Exceed) Dundern, Saskatchewan Rape (45A51) Brookdale, Manitoba Rape (45A1) Wakaw, Saskatchewan day spray intervals a d 41+10d 41+15d,,,,,,,,,,,,,,,, 56,, 54,, ,, ,, Max 0.6 kg ai/ha/year Max 0.6 kg ai/ha/year, 64, J D, M , 33d spray intervals, 64, J D, M , 2d spray intervals, 64 J60-00H M d spray intervals, 64 J H M d spray intervals, 64 J H M d spray intervals, 64 J601-00H M d spray intervals

17 Prothioconazole 899 OIL SEED RAPE (Var) Rape (SW Legion) Hepburn, Saskatchewan Rape (46A6) Rosthern, Saskatchewan Rape (Quest) Blaine Lake, Saskatchewan, Rape (LG3235) Lacombe, Alberta Rape (Round up ready, Quest) Kemnay, Manitoba, Rape (223 invigor) Carberry, Manitoba Rape (Q2) Kipp, Alberta, Rape (Agassiz) Leduc, Alberta Rape (Agassiz) Gwyne, Alberta Rape (46A65) Glenboro, Manitoba Rape (Flint) Chula, Georgia Rape (Quantum) Northwood, N Dakota Rape (Quantum) New Rockford, N Dakota, kg ai/ha kg Residues (mg/kg) in rape seed ,, ,, ,, ,, ,,, 64 J H M d spray intervals, 64 J H M d spray intervals, 64 J H M d spray intervals, 64 J H M d spray intervals, 64 J H M d spray intervals 1, 0.03, 0.029, 64 J HA M d spray intervals ,, , J H M d spray intervals ,, ,, 5,, 8,, 43,, 36,,, 64 J H M d spray intervals, 64 J H M nd app BBCH 6 44d spray intervals, 64 J602-00H M d spray intervals, 64 J H M d spray intervals, 64 J H M d spray intervals, 64 J612-00H M d spray intervals

18 900 Prothioconazole OIL SEED RAPE (Var) Rape (RaideRR) Ashton, Idaho, Rape (Chinook) Ashton, Idaho Rape (46A4) Melfort, Saskatchewan kg ai/ha kg Residues (mg/kg) in rape seed 55,,, 64 J H M d spray intervals 3, , , J HA M d spray intervals 58,, a Samples harvested 41 DAT and collected after 0, 5, 10 and 15 days field drying, 64 J H M d spray intervals Peanut The 2008 JMPR received information on 12 residue trials on peanuts carried out with prothioconazole SC 480 in the. Four foliar spray applications of prothioconazole 480 SC were made to peanuts at a target rate of 202 g/ha/application (actual rate ranged from 202 to 213 g/ha) using spray volumes ranging from 122 to 346 L/ha. The interval between applications was 12 to 15 days. All applications were made using ground-based equipment. Samples were collected at ± 1 days. As a part of normal agricultural practice for growing peanuts, following digging, the peanuts with shells and the peanut hay samples were both allowed to dry in the field for five to eight days prior to collecting the samples (except for trial J H in which the samples were only dried for two days due to the threat of rain). The for the peanuts and peanut hay is based on the date that the peanut plants were dug. Residues of desthio-prothioconazole and prothioconazole sulfonic acid in peanut nutmeat and hay were analysed using Method RPA JA/03/01 which extracts residues of the desthio metabolite unchanged, converts prothioconazole residues to a mixture of the sulfonic acid and desthio metabolites and measures these two components seperately using LC/MS-MS. The reported limit of quantification for both residue components are 0.02 mg/kg in nutmeat and 0.05 mg/kg in hay. Table 10 summarises the results in peanut nutmeat from these trials, initially reported in the 2008 JMPR Evaluation (Prothioconazole Table 64), with the inclusion of the additional information on residues of prothioconazole sulfonic acid and desthio-prothioconazole [BCS ]. Table 10 Residues in peanut meat from trials conducted with four foliar applications of prothioconazole (JAU SC) on peanuts in PEANUT (Var) kg ai/ha kg Residues (mg/kg) in peanut meat Groundnut () 4 x 0.2 Max 0.8 kg ai/ha/year SC 480 Groundnut () 4 x With tebuconazole (28) SC 3

19 Prothioconazole 901 PEANUT (Var) kg ai/ha kg Residues (mg/kg) in peanut meat Peanut (Georgia Greens) Tifton, Georgia ,,,,,,,,,,,, J D Peanut (VA 98R_ Suffolk, Virginia ,,, J H Peanut (NC 12C, Lot G- 2204) Jamesville, N Carolina ,,, J H Peanut (VAC92RCV92R54399) Roper, North Carolina ,,, J H Peanut (Georgia Green) Inaha, Georgia ,,, J H Peanut (AgraTech 201) Herod, Georgia, ,,, J H Peanut (Georgia Green) Columbia, Alabama ,,, J H Peanut (VA 98R) Knightdale, N Carolina ,,, J H Peanut (Georgia Green) Vero Beach, Florida ,,, J603-00H Peanut (TAMRun) Vernon, Texas, ,,, J H Peanut (TAMRun) Vernon, Texas, ,,, J H Peanut (Spanco) Eakly, Oklahoma, ,,, J H Primary feed commodities The 2008 JMPR evaluated prothioconazole residue information from North America on a number of primary feed commodities and concluded that the data from these trials could not be used for estimation of residue levels because only the total residue was reported.

20 902 Prothioconazole The present meeting received further information on the the individual residue components measured in the trials from and on the following primary feed commodites and these new data are included in the following tables (initially summarised in the 2008 JMPR Evaluation of prothioconazole). Sugar beet tops Table 11 summarises the results in sugar beet tops from sugar beet trials in and, initially reported in the 2008 JMPR Evaluation (Prothioconazole Table 6), with the inclusion of the additional information on residues of prothioconazole sulfonic acid and desthio-prothioconazole [BCS ]. Table 11 Residues in sugar beet tops from trials conducted with three foliar applications of prothioconazole (JAU SC) on sugar beet in SUGAR BEET (Var) kg ai/ha kg Residues (mg/kg) in sugar beet tops Sugar beet () Maximum 0.6 kg ai/ha/year Sugar beet (unknown) Springfield, Nebraska Sugar beet (Tonic) Sabin, Minnesota Sugar beet (Talbot) Rockwood, Ontario Sugar beet (Hilleshog 2433RZ) Britton, South Dakota Sugar beet (66283 Medium) Theilman, Minnesota Sugar beet (Crystal 955) Velva, North Dakota Sugar beet (Wrangler) Levelland, Texas, Sugar beet (Beta 85 LL) Jerome, Idaho, Sugar beet (Beta 4430R) Porterville, California , , , , , , , , , , , , 0.1, , , , , 0.55, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , 1.5 JA001-04D M JA002-04H M JA003-04H M JA004-04H M JA005-04H M JA006-04H M JA00-04H M JA008-04H M JA009-04H M

21 Prothioconazole 903 SUGAR BEET (Var) kg ai/ha kg Residues (mg/kg) in sugar beet tops Sugar beet (Alpine), Fresno, California , , , , , , 1.1 JA010-04H M Sugar beet (Beta 4490R) Rupert, Idaho, , 0.19, , , , , 0.35 JA011-04H M Sugar beet (Beta 4490R) Twin Falls, Idaho, , , , , , 0.31 JA012-04H M Wheat forage Table 12 summarises the results in wheat forage from wheat trials in and, initially reported in the 2008 JMPR Evaluation (Prothioconazole Tables 1 and 2), with the inclusion of the additional information on residues of prothioconazole sulfonic acid and desthio-prothioconazole [BCS ]. Table 12 Residues in wheat forage from trials conducted with two foliar applications of prothioconazole (JAU SC) on wheat in North America WHEAT (Variety) kg ai/ha kg Residues (mg/kg) in wheat forage Wheat () SC 480 Wheat () 1+1 a b Maximum 0.33 kg ai/ha/year SC 480 Wheat (Russ Wheat) New Rockford, N Dakota Wheat (Arapahoe) Louisville, Nebraska Wheat, winter (Pioneer 2684) Tifton, Georgia 2003 Wheat, winter (Pioneer 2684) Leland, Mississippi 2003 Wheat, winter (Jagger) Stilwell, Kansas 2003 Wheat. winter (Wahoo W3-43) Louisville, Nebraska , , , , , 0.18, , , , , , , , , , , , , , , 0.33 J D J D 0.09, , , 0.38 J H 0.65, , , 2.9 J610-00H, , , 0.3 J611-00H 0.26, , , 1.2 J612-00H

22 904 Prothioconazole WHEAT (Variety) Wheat. winter (Ogallala) Uvalde, Texas, Wheat. spring (Alsen) New Rockford, N Dakota Wheat. spring (Alsen) Eldridge, N Dakota Wheat. spring (Ingot) Leola, South Dakota Wheat. spring (CDC Teal) Dundum, Saskatchewan Wheat. spring (A.C. Barrie) Taber, Alberta, Wheat. winter (Tam 105) Levelland, Texas, 2003 Wheat. winter (Jagger) Hart, Texas, 2003 Wheat. winter (Tam 105) Wolforth, Texas, 2003 Wheat. winter (Coker 9663) Colony, Oklahoma, 2003 Wheat. spring (Pennewawa) Hood River, Oregon, Wheat. spring (AC Barrie) Minto, Manitoba, Wheat. spring (Prodigy) Rosthern, Saskatchewan Wheat. spring (AC Splender) Edmonton, Alberta, Wheat. spring (AC Splender Spruce Grove, Alberta kg ai/ha kg Residues (mg/kg) in wheat forage 1.6, , 3..0, 4. J613-00H 0.059, 0.3, , 0.3 J614-00H 0.08, , 0.12 J615-00H 0.05, 0.068, J616-00H 0.41, , , 2.9 J61-00H 0., , , 1.8 J618-00H 0.42, , , 1. J619-00H 0.3, , , 1.3 J H 0.46, , , 2.3 J H 0.21, , , 1.4 J H 0.21, , , 0.9 J H 0.1, , 0. J H 0.13, , , 0.8 J H 0.29, , , 1.2 J H 0.11, , , 1.4 J618-00H

23 Prothioconazole 905 WHEAT (Variety) Wheat. spring (AC Cora) Brookdale, Manitoba Wheat. spring (AC Cora) Bethany, Manitoba kg ai/ha kg Residues (mg/kg) in wheat forage 0.15, , , 2.1 J H 0.29, , , 1. J H a Maximum rate/ha/year requires at least 1 application at less than the maximum rate/ha b of 5 days for wheat forage used by US EPA for establishing an MRL for wheat forage. Wheat fodder (hay and straw) Table 13 summarises the results in wheat hay and straw from the trials in and, initially reported in the 2008 JMPR Evaluation (Prothioconazole Tables 1 and 2), with the inclusion of the additional information on residues of prothioconazole sulfonic acid and desthio-prothioconazole [BCS ]. Table 13 Residues in wheat hay and straw from trials conducted with two foliar applications of prothioconazole (JAU SC) on wheat in North America WHEAT (Variety) Residues (mg/kg) in wheat fodder kg ai/ha kg Wheat () SC 480 Wheat () a Max 0.33 kg ai/ha/yr SC 480 Wheat (Russ Wheat) New Rockford. N Dakota Wheat (Arapahoe) Louisville Nebraska Wheat (Tahoe) St. George. Ontario Wheat (Penawawa) Hermiston. Oregon hay hay 20 hay 28 hay 36 strw 40 strw 46 strw 50 strw hay hay 21 hay 28 hay 35 strw 39 strw 44 strw 49 strw 1 hay 42 strw 13 hay 42 strw 0.4, , , , , , , 0.04, 0.084, , , 0.06, 0.05, 2.6, , , , , , , , 0.69, , , , , , , , 0.26, , , , , , , , , , , n.a. 0.31, , , , , < , , , , , , , , 0.11 J D J D J H J604-00H

24 906 Prothioconazole WHEAT (Variety) Wheat (Ogallala) Uvalde. Texas, Wheat (Jagger) Claude. Texas, Wheat (Custer) Cordell. Oklahoma Wheat (Custer) Frederick. Oklahoma Wheat (Tam 200) Hart. Texas, Wheat (235) Velva. North Dakota Wheat (Tam 202. Lot Star 10) Levelland. Texas, Wheat (Alsen) Ellendale. N Dakota Wheat (Forge spring wheat) Lake Andes. S Dakota Wheat (Tahoe) Paris. Ontario, Wheat (Mit) East Bernard. Texas Wheat (Karl 92) Stilwell. Kansas, Wheat (Becks 10) Oxford. Indiana, Wheat (Barrie) Red Deer. Alberta, Wheat (HRS wheat prodigy) Monarch. Alberta, Residues (mg/kg) in wheat fodder kg ai/ha kg hay 42 strw hay 41 strw hay 38 strw hay 40 strw 13 hay 35 strw 13 hay 33 strw 13 hay 43 strw 12 hay 39 strw 13 hay 46 strw 1 hay 42 strw 12 hay 32 strw 16 hay 42 strw hay 43 strw hay 5 strw hay 30 strw 0.53, , , , , , , , , , , , , , 0.1 n.a., , , , , , 0.086, , , , , , , , , , , , , , , , , , , , 2.2 n.a., , , , , , , , , , , , , , , , , , , , , , , , , , , , , 2.4 n.a., , , , , , , , , , , , , 0.39 J H J H J H J H J H J H J H J H J H J605-00H J H J H J H J H J H

25 Prothioconazole 90 WHEAT (Variety) Wheat (Pioneer 2684) Benoit. Mississippi Wheat (Cooker 10) Knightdale. N Carolina Wheat (AC Cora) Minto. Manitoba, Wheat (AC Cora) Minto. Manitoba, Wheat (AC Barrie) Wakaw. Saskatchewan Wheat (McKenzie) Leask. Saskatchewan Wheat (AC Cadillac) Rostern. Saskatchewan Wheat (Barrie (certified)) Brookdale. Manitoba Wheat (Barrie ) Lacombe. Alberta, Wheat (AC Barrie ) Delisle. Saskatchewan Wheat (Prodigy) Delisle. Saskatchewan Wheat (HRS wheat prodigy) Warner. Alberta, Wheat (Prodigy) Coaldale. Alberta, Wheat (Prodigy) Kipp. Alberta, Residues (mg/kg) in wheat fodder kg ai/ha kg hay 42 strw hay 3 strw hay 4 strw hay 49 strw 12 hay 55 strw 12 hay 48 strw hay 53 strw hay 43 strw hay 5 strw 15 hay 38 strw 15 hay 43 strw hay 31 strw hay 35 strw hay 30 strw 0.21, , , , , , , , , , , , , , 0.66, , , , , , , 0.43, , , , , , , , , , , , , , , , , , , , , , , , , , , , 1.9, , , , , , 0.41 a Maximum rate/ha/year requires at least 1 application at less than the maximum rate/ha 1.8, , , , , , , , , , , , , , , , , , , , , , , , , , , , J H J H J H J606-00H J H J H J600-00H J601-00H J602-00H J603-00H J604-00H J605-00H J606-00H J60-00H

26 908 Prothioconazole Barley fodder (hay and straw) Table summarises the results in barley hay and straw from the barley trials in and, initially reported in the 2008 JMPR Evaluation (Prothioconazole Table 5), with the inclusion of the additional information on residues of prothioconazole sulfonic acid and desthio-prothioconazole [BCS ]. Table Residues in barley hay and straw from trials conducted with two foliar applications of prothioconazole (JAU SC) on barley in North America BARLEY (Variety) kg ai/ha kg Residues (mg/kg) in barley fodder Barley () SC 480 Barley () a Max 0.33 kg ai/ha/year SC 480 Barley (Robust) Northwood N Dakota Barley (Steptoe) Hermiston Oregon Barley (Baretta) Maricopa. Arizona, Barley (Baretta) Wilcox. Arizona, Barley (Robust) Velva. N Dakota, Barley (Robust) New Rockford. N Dakota, Barley (Robust) Ellendale. N Dakota Barley (Chapais) Branchton. Ontario Barley (Morex) Jerome. Idaho, Barley (Robust) Northwood. N Dakota hay 13 hay 22 hay 28 hay 32 strw 3 strw 44 strw 4 strw 13 hay 42 strw hay 48 strw 15 hay 1 strw 13 hay 33 strw hay 36 strw hay 43 strw 9 hay hay 21 hay 29 hay 36 strw 39 strw 45 strw 49 strw 12 hay 43 strw hay 44 strw 0.066, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , 0.36, , , , , , , , , , , , , , , , , , , , , , 0.55, , , , , , , , , , , , , 0.11 J D J H J H J H J H J H J600-00H J D J H J H

27 Prothioconazole 909 BARLEY (Variety) kg ai/ha Barley (AC Stephen) Germansville, Pennsylvania, Barley (Robust) Minto. Manitoba, Barley (Robust) Minto. Manitoba, Barley (AC Rosser) Brookdale. Manitoba Barley (Bedford) Clanwilliam Manitoba Barley (AC Metcalf) Marcelin. Saskatchewan Barley (Harrington) Rosthem. Saskatchewan Barley (Harrington) Wakaw. Saskatchewan Barley Lacombe. Alberta, Barley Penhold. Alberta, Barley (Stein) Rosthem. Saskatchewan Barley (AC Harper) Kipp. Alberta, Barley (Lacombe) Leduc. Alberta, Barley (Excel) Delisle. Saskatchewan Barley (Chapais) St-Paul-d'Abbotsford. Quebec, kg hay 5 strw 13 hay 36 strw 16 hay 32 strw hay 43 strw hay 65 strw 12 hay 48 strw 12 hay 43 strw 15 hay 34 strw 13 hay 1 strw 13 hay 1 strw 13 hay 52 strw hay 4 strw 15 hay 33 strw 15 hay 30 strw 15 hay 36 strw Residues (mg/kg) in barley fodder 0.096, 0.1, , , , , , , , , , , , , , , , , , , 0.13, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , 1.3 a Maximum rate/ha/year requires at least 1 application at less than the maximum rate/ha 1.19, , , , , , , , , , , , , , , , , , , , , 0. 0., , , , , , , , 1.4 J H J608-00H J609-00H J H J H J H J H J H J H J H J608-00H J H J H J H J H

28 910 Prothioconazole Soya bean forage Table 15 summarises the results in soya bean forage from the soya bean trials in, initially reported in the 2008 JMPR Evaluation (Prothioconazole Table 8), with the inclusion of the additional information on residues of prothioconazole sulfonic acid and desthio-prothioconazole [BCS ]. Table 15 Residues in soya bean forage from residue trials conducted with three foliar applications of prothioconazole ( SC) on soya beans in SOYA BEAN (Variety) kg ai/ha kg GS Residues (mg/kg) in soya bean forage Soya bean () Min 0 L/ha (ground), 4 L/ha (air) 480 SC Soya (Pioneer 96M20) Molino, Florida Soya (Stine 288) Seymour, Illinois Soya (Pioneer RR 9B52) Tifton, Georgia, Soya (Pioneer 9492RR) Leland, Mississippi, Soya (DP 5915 RR) Washington, Louisiana Soya (NKS28W2) Springfield Nebraska Soya (Jim) Sabin, Minnesota Soya (Croplan RT090) Britton, South Dakota Soya (Croplan RT4) Dumfries, Minnesota Soya (SC934) New Holland, Ohio , 0.91 a 0.26, , , , a, 1.0 a 0.82 a, , , , , 2.5 a 0.94, , , , a, 2.6 a 1. a, , , , , 3.4 a 1.2, , , , a, 3.6 a 2.6 a, , , , 0.43 RAJAY026 JA0-04D-P1 RAJAY026 JA019-04D-P , , , 1.1 RAJAY026 JA015-04H-P , , , 1.6 RAJAY026 JA016-04H-P , , , 1.8 RAJAY026 JA01-04H-P , , , 1.5 RAJAY026 JA021-04H-P , , , 0.4 RAJAY026 JA022-04H , , , 1. RAJAY026 JA024-04H-P , , , 1.6 RAJAY026 JA025-04H-P , , , 1.2 RAJAY026 JA026-04HA