GROUP LA GARDONNENQUE. La Gardonnenque SCA since INOSUD SA since people. 25 M Turnover

Transcription

1 GROUP LA GARDONNENQUE La Gardonnenque SCA since 1969 INOSUD SA since people 25 M Turnover

2 TRADITIONAL PRODUCTS OENOLOGY Alcohol Seeds Grape Seed Oil Calcium Tartrate Tartaric Acid Compost, Pulps, Natural Sugar (1988) Tannins (2002)

3 DIVERSIFICATION (1994) FOOD INDUSTRY Grape Skin Extract E163 Grape Juice Concentrates Wine Extracts

4 DIVERSIFICATION 2 (1997) NUTRACEUTICALS Grape Seed Extracts Polyphenols from Grape Anthocyanins Resveratrol (2002)

5 INOSUD SA : SUBSIDIARY Olive Polyphenols Black Carrot Concentrate

6 THE FRENCH PARADOX Epidemiological studies (St LEGER, 1979 / Dr RENAUD, Dr LOREGIL 1992) Moderate consumption of red wine = decrease of heart disease, cardio-protective effects.

7 THE FRENCH PARADOX CBS s 60 minutes (1991) : «moderate wine consumption is associated with much lower risk of heart disease and stroke, leading causes of death in the USA». R.CURTIS ELLISON, Chief of Preventive Medicine and Epidemiology, Boston University School of Medicine => The FRENCH PARADOX was born

8 POLYPHENOLS FROM GRAPE LA GARDONNENQUE SCA CRUVIERS-LASCOURS Tel.: Fax: Web : gardo@gardonnenque.fr

9 PRESENTATION Extract from selected red grapes Contains the polyphenols of RED WINE 2 glasses of wine 400mg of ExGrape Total Standardised in Procyanidins Anthocyanins Resveratrol

10 MANUFACTURING PROCESS Grape marc selection 500kg Solvents: water, ethanol Preservation of the active principles properties Acqueous Extraction Purification / standardisation of polyphenols Concentration under vacuum Spray drying 1kg

11 COMPOSITION Total Polyphenols(OD280nm) > 92% Procyanidins (VANILLIN) > 15% Anthocyanins (RIBEREAU-GAYON) > 2% Trans-resveratrol(HPLC) > 100 ppm

12 CHARACTERISTICS 1 Anti free radicals and anti oxidant activity ORAC VALUE test Comparaison with Various vegetal extracts and vitamin C (LAREAL data) ORAC value (µmole TE/g) ExGrape Total 0 Rosemary Green tea Ascorbic acid

13 CHARACTERISTICS 2 Prevention of atherosclerotic diseases Reduction of aortic lipid deposition on hamster AUGER, ROUANET (J. Agric. Food Chem. 2004) 6 Lipid deposition (%) Control Red Wine -57% ExGrape Total ExGrape Total decreases aortic lipid deposition by more than 57%

14 CHARACTERISTICS Reduction of aortic lipid deposition on hamster Dépôt Lipid deposition in the aortic arch Control Red Wine ExGrape Total

15 APPLICATIONS Food Supplements Beverages Confectionery

16 CONCLUSION KEY BENEFITS A unique total profile of red wine polyphenols 100% water and alcohol soluble Greater antioxidant activity than catechin and lycopene An effect on aortic lipid deposition shown by scientific studies An ORAC value (over ) superior to other grape branded extracts

17 References 1) AUGER Cyril et al. (2002) Red wine Phenolic Compounds reduce plasma lipids and apolipoprotein B and prevent early aortic atherosclerosis in hypercholesterolemic golden Syrian hamsters. American Society for Nutritional Sciences, p ) ZERN Tosca L. et al. (2003) Grape Polyphenols decrease plasma triglycerides and Cholesterol accumulation in the aorta of ovariectomized Guinea pigs. American Society for Nutritional Sciences, p

18 References 3) AUGER Cyril et al. (2003) Procyanidins and anthocyanidins rich grape extracts prevent early atherosclerosis in hypercholesterolemic hamsters 1 st International Conference of Polyphenols and health. Vichy November 2003, France 4) MANIJEH-SHAFIEE et al. (2003) Grape and grape seed Extract capacities at protecting LDL against oxidation generated by Cu2+, AAPH or SIN-1 and at decreasing superoxide THP-1 cell production. A comparison to other extracts or compounds. Free Radical Research, 2003, Vol 37 (5), pp ) AUGER Cyril et al. (2004) Phenolics from commercialized grape extracts prevent early Atherosclerotic Lesions in hamsters by mechanisms other than antioxidant effect. Journal of Agricultural and Food Chemistry, 2004, 52,