Metabolism.

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2 Metabolism Metabolism is the set of life-sustaining chemical transformations within the cells of living organisms. The three main purposes of metabolism are the conversion of food/fuel to energy to run cellular processes, the conversion of food/fuel to building blocks for proteins, lipids, nucleic acids, and some carbohydrates, and the elimination ofnitrogenous wastes. These enzymecatalyzed reactions allow organisms to grow and reproduce, maintain their structures, and respond to their environments. The word metabolism can also refer to the sum of all chemical reactions that occur in living organisms, including digestion and the transport of substances into and between different cells, in which case the set of reactions within the cells is called intermediary metabolism or intermediate metabolism. Metabolism is usually divided into two categories: catabolism, the breaking down of organic matter, for example, by cellular respiration, and anabolism, the building up of components of cells such as proteins and nucleic acids. Usually, breaking down releases energy and building up consumes energy. The chemical reactions of metabolism are organized into metabolic pathways, in which one chemical is transformed through a series of steps into another chemical, by a sequence of enzymes. In a broad sense, a metabolic disorder is any disease that is caused by an abnormal chemical reaction in the body's cells. Most disorders involve either abnormal levels of enzymes or hormones, or problems with how those enzymes or hormones work.when the metabolism of body chemicals is blocked or defective, it can cause a buildup of toxic substances in the body or a lack of substances needed for normal body function, either of which can lead to serious symptoms. 1

3 Pathways and Processes Cat. No. Product Name Name Detection Range Sensitivity E-EL-H0002 Human ACE (Angiotensin I Converting Enzyme) ng/mL 0.47ng/mL Sandwich E-EL-H0004 Human ADP/Acrp30 (Adiponectin) ng/mL 0.47ng/mL Sandwich E-EL-H0006 Human ANG (Angiogenin) pg/mL 9.38pg/mL Sandwich E-EL-H0017 Human CASP3 (Caspase 3) ng/mL 0.19ng/mL Sandwich E-EL-H0020 Human MCP-1 (Monocyte Chemotactic Protein 1) pg/mL 9.38pg/mL Sandwich E-EL-H0054 Human CXCL16 (Chemokine C-X-C-Motif Ligand 16) ng/mL 0.09ng/mL Sandwich E-EL-H0056 Human Cyt-C (Cytochrome C) pg/mL 46.88pg/mL Sandwich E-EL-H0064 Human ET-1 (Endothelin 1) pg/mL 0.75pg/mL Sandwich E-EL-H0066 Human EPO (Erythropoietin) pg/mL 18.75pg/mL Sandwich E-EL-H0074 Human FGF21 (Fibroblast Growth Factor 21) pg/mL 18.75pg/mL Sandwich E-EL-H0086 Human IGF-1 (Insulin-Like Growth Factor 1) ng/mL 0.94ng/mL Sandwich 2 Focus on Lab Research Service for Life Science

4 E-EL-H0093 Human LEPR (Leptin Receptor) ng/mL 0.19ng/mL Sandwich E-EL-H0096 E-EL-H0111 Human NGAL (Neutrophil Gelatinase Associated Lipocalin) Human VEGF-A (Vascular Endothelial Cell Growth Factor A ) ng/mL 0.09ng/mL Sandwich pg/mL 18.75pg/mL Sandwich E-EL-H0125 Human ApoA1 (Apolipoprotein A1) ng/mL 1.88ng/mL Sandwich E-EL-H0142 Human MYO (Myoglobin) ng/mL 1.88ng/mL Sandwich E-EL-H0148 Human GLP-1 (Glucagon Like Peptide 1) ng/mL 0.19ng/mL Sandwich E-EL-H0208 Human 12-HETE (12-Hydroxyeicosatetraenoic Acid) ng/mL 0.47ng/mL Competitive E-EL-H0232 Human 5-HETE (5-Hydroxyeicosatetraenoic Acid) ng/mL 0.09ng/mL Competitive E-EL-H0327 Human Ang-I (Angiotensin I) pg/mL 75pg/mL Competitive E-EL-H0337 Human ANGPTL4 (Angiopoietin Like Protein 4) ng/mL 0.94ng/mL Sandwich E-EL-H0462 Human ApoA2 (Apolipoprotein A2) ng/mL 37.5ng/mL Sandwich E-EL-H0464 Human ApoB (Apolipoprotein B) ng/mL 46.88ng/mL Sandwich E-EL-H0465 Human ApoC1 (Apolipoprotein C1) ng/mL 5.63ng/mL Sandwich Focus on Lab Research Service for Life Science 3

5 E-EL-H0466 Human ApoC2 (Apolipoprotein C2) ng/mL 1.88ng/mL Sandwich E-EL-H0467 Human ApoC3 (Apolipoprotein C3) ng/mL 4.69ng/mL Sandwich E-EL-H0562 Human Bax (Bcl-2 Associated X Protein) ng/mL 0.47ng/mL Sandwich E-EL-H0698 Human CHEM(Chemerin) ng/mL 0.09ng/mL Sandwich E-EL-H0838 Human LDHB (Lactate Dehydrogenase B) ng/mL 1.88ng/mL Sandwich E-EL-H0965 Human α1-at (Alpha 1-Antitrypsin) ng/mL 1.88ng/mL Sandwich E-EL-H0966 Human PLCγ2 (Phospholipase C Gamma 2, Phosphatidylinositol Specific) ng/mL 0.19ng/mL Sandwich E-EL-H1026 Human PRDX5 (Peroxiredoxin 5) ng/mL 0.09ng/mL Sandwich E-EL-H1087 Human VEGFR1/FLT1 (Vascular Endothelial Growth Factor Receptor 1) pg/mL 75pg/mL Sandwich E-EL-H1090 Human PDH E1 (Pyruvate Dehydrogenase E1) pg/mL 18.75pg/mL Sandwich E-EL-H1092 Human PDK4(Pyruvate Dehydrogenase Kinase Isozyme 4) ng/mL 0.94ng/mL Sandwich E-EL-H1141 Human TSH (Thyroid Stimulating Hormone) ng/mL 0.09ng/mL Sandwich E-EL-H1161 Human PRDX1 (Peroxiredoxin 1) pg/mL 9.38pg/mL Sandwich 4 Focus on Lab Research Service for Life Science

6 E-EL-H1174 Human PKB (Protein Kinase B) ng/mL 0.09ng/mL Sandwich E-EL-H1213 Human RETN (Resistin) pg/mL 18.75pg/mL Sandwich E-EL-H1260 Human NNE (Non-Neuronal Enolase) ng/mL 0.19ng/mL Sandwich E-EL-H1298 Human SDC1 (Syndecan 1) ng/mL 0.09ng/mL Sandwich E-EL-H1324 Human Smad3/MADH3 (Mothers Against Decapentaplegic Homolog 3) ng/mL 0.38ng/mL Sandwich E-EL-H1433 Human CKM (Creatine Kinase, Muscle) ng/mL 0.94ng/mL Sandwich E-EL-H1544 Human SOST (Sclerostin) pg/mL 37.5pg/mL Sandwich E-EL-H1575 E-EL-H1606 Human PDGF-AA (Platelet Derived Growth Factor-AA) Human EMMPRIN/CD147 (Extracellular Matrix Metalloproteinase Inducer) pg/mL 9.38pg/mL Sandwich pg/mL 9.38pg/mL Sandwich E-EL-H1634 Human FXN (Frataxin) pg/mL 14.06pg/mL Sandwich E-EL-H1657 Human TGFβI (Transforming Growth Factor Beta Induced Protein) ng/mL 0.38ng/mL Sandwich E-EL-H1817 Human GPI (Glucose 6 Phosphate Isomerase) pg/mL 18.75pg/mL Sandwich E-EL-H2086 Human ERK1 (Extracellular Signal Regulated Kinase 1) ng/mL 0.19ng/mL Sandwich Focus on Lab Research Service for Life Science 5

7 E-EL-H2087 E-EL-H2115 E-EL-H2130 Human ERK2 (Extracellular Signal Regulated Kinase 2) Human SOD2 (Superoxide Dismutase 2, Mitochondrial) Human STAT1 (Signal Transducer and Activator of Transcription 1) pg/mL 28.13pg/mL Sandwich ng/mL 0.19ng/mL Competitive ng/mL 0.09ng/mL Sandwich E-EL-H2172 Human HO1 (Heme Oxygenase 1) ng/mL 0.19ng/mL Sandwich E-EL-H2183 Human SAA (Serum Amyloid A) ng/mL 0.75ng/mL Sandwich E-EL-H2358 Human 11,12-DHETs(11,12-dihydroxyeicosatrienoic acids) ELISA ng/mL 0.94ng/mL Competitive E-EL-H5408 Human CAT(Catalase) pg/mL 9.38pg/mL Sandwich E-EL-H5449 Human PDH (Pyruvate Dehydrogenase ) ng/mL 0.09ng/mL Sandwich E-EL-H5546 Human SDH (Succinate Dehydrogenase) ng/mL 0.19ng/mL Sandwich E-EL-H5619 Human HPX(Hemopexin) ng/mL 0.94ng/mL Sandwich E-EL-M0002 Mouse ADP/Acrp30 (Adiponectin) pg/mL 9.38pg/mL Sandwich E-EL-M0006 Mouse MCP-1 (Monocyte Chemotactic Protein 1) pg/mL 9.38pg/mL Sandwich E-EL-M0015 Mouse CHEM (Chemerin) pg/mL 28.13pg/mL Sandwich 6 Focus on Lab Research Service for Life Science

8 E-EL-M0023 Mouse Cyt C (Cytochrome C) ng/mL 0.23ng/mL Sandwich E-EL-M0027 Mouse EPO (Erythropoietin) pg/mL 46.88pg/mL Sandwich E-EL-M0034 Mouse IGF-1 (Insulin-like growth factor 1) pg/mL 46.88pg/mL Sandwich E-EL-M0051 Mouse TGF-β1 (Transforming Growth Factor β1) pg/mL 18.75pg/mL Sandwich E-EL-M0084 Mouse MYO (Myoglobin) ng/mL 0.94ng/mL Sandwich E-EL-M0090 Mouse GLP-1 (Glucagon Like Peptide 1) pg/mL 9.38pg/mL Sandwich E-EL-M0091 Mouse ACE (Angiotensin I Converting Enzyme) ng/mL 0.19ng/mL Sandwich E-EL-M0132 Mouse ApoB (Apolipoprotein B) ng/mL 18.75ng/mL Sandwich E-EL-M0236 Mouse CT-1 (Cardiotrophln 1) pg/mL 9.38pg/mL Sandwich E-EL-M0238 Mouse CASP3 (Caspase 3) ng/mL 0.09ng/mL Sandwich E-EL-M0270 Mouse CXCL16 (Chemokine C-X-C-Motif Ligand 16) pg/mL 18.75pg/mL Sandwich E-EL-M0358 Mouse CKM (Creatine Kinase, Muscle) ng/mL 0.94ng/mL Sandwich E-EL-M0457 Mouse ET-1 (Endothelin 1) pg/mL 4.69pg/mL Sandwich Focus on Lab Research Service for Life Science 7

9 E-EL-M0480 E-EL-M0481 Mouse ERK1 (Extracellular Signal Regulated Kinase 1) Mouse ERK2 (Extracellular Signal Regulated Kinase 2) pg/mL 46.88pg/mL Sandwich ng/mL 1.0ng/mL Sandwich E-EL-M0565 Mouse GPI (Glucose 6 Phosphate Isomerase) ng/mL 0.19ng/mL Sandwich E-EL-M0630 Mouse PDGF-AA (Platelet-Derived Growth Factor-AA) pg/mL 15.6pg/mL Sandwich E-EL-M0635 Mouse RETN (Resistin) pg/mL 46.88pg/mL Sandwich E-EL-M0648 Mouse FLT1/VEGFR1 (Vascular Endothelial Growth Factor Receptor 1) ng/mL 0.09ng/mL Sandwich E-EL-M0651 Mouse HO-1 (Heme Oxygenase 1) pg/mL 9.38pg/mL Sandwich E-EL-M0749 Mouse LEPR (Leptin Receptor) pg/mL 18.75pg/mL Sandwich E-EL-M0828 Mouse NGAL (Neutrophil Gelatinase Associated Lipocalin) pg/mL 23.44pg/mL Sandwich E-EL-M0996 Mouse PDHa (Pyruvate Dehydrogenase Alpha) ng/mL 0.09ng/mL Sandwich E-EL-M0997 Mouse PDK4 (Pyruvate Dehydrogenase Kinase Isozyme 4) ng/mL 0.19ng/mL Sandwich E-EL-M0999 Mouse PDH E1 (Pyruvate Dehydrogenase-E1) ng/mL 0.94ng/mL Sandwich E-EL-M1046 Mouse SAA (Serum amyloid A) ng/mL 0.94ng/mL Sandwich 8 Focus on Lab Research Service for Life Science

10 E-EL-M1055 Mouse STAT1 (Signal Transducer And Activator Of Transcription ng/mL 0.19ng/mL Sandwich E-EL-M1153 Mouse TSH (Thyroid Stimulating Hormone) ng/mL 0.75ng/mL Sandwich E-EL-M2424 Mouse SOD2 (Superoxide Dismutase 2, Mitochondrial) ELISA ng/mL 0.19ng/mL Competitive E-EL-M2428 Mouse α1-at (Alpha 1-Antitrypsin) ng/mL 1.88ng/mL Sandwich E-EL-M2435 Mouse SOST (Sclerostin) pg/mL 9.38pg/mL Sandwich E-EL-M2440 Mouse DPP4 (Dipeptidyl Peptidase IV) pg/mL 37.5pg/mL Sandwich E-EL-M2460 Mouse SDC1 (Syndecan 1) ng/mL 0.09ng/mL Sandwich E-EL-M2462 Mouse ApoA2 (Apolipoprotein A2) pg/mL 4.69pg/mL Sandwich E-EL-M2619 Mouse MAOB(Amine oxidaseb)elisa kit pg/mL 9.38pg/mL Sandwich E-EL-M2632 Mouse MPO(Myeloperoxidase) pg/mL 37.5pg/mL Sandwich E-EL-R0006 Rat Cyt-C (Cytochrome C) ng/mL 0.23ng/mL Sandwich E-EL-R0010 Rat IGF-1 (Insulin-Like Growth Factor 1) pg/mL 18.75pg/mL Sandwich E-EL-R0053 Rat MYO (Myoglobin) ng/mL 0.38ng/mL Sandwich Focus on Lab Research Service for Life Science 9

11 E-EL-R0059 Rat GLP-1 (Glucagon Like Peptide 1) pg/mL 9.38pg/mL Sandwich E-EL-R0084 Rat TGF-β1(Transforming Growth Factor β1) pg/mL 18.75pg/mL Sandwich E-EL-R0160 Rat CASP3 (Caspase 3) ng/mL 0.19ng/mL Sandwich E-EL-R0167 Rat ET-1 (Endothelin 1) pg/mL 4.69pg/mL Sandwich E-EL-R0189 Rat CXCL16 (Chemokine C-X-C-Motif Ligand 16) ng/mL 0.09ng/mL Sandwich E-EL-R0274 Rat CKM (Creatine Kinase, Muscle) ng/mL 0.94ng/mL Sandwich E-EL-R0329 Rat ADP/Acrp30 (Adiponectin) pg/mL 28.13pg/mL Sandwich E-EL-R0488 Rat HO-1 (Heme Oxygenase 1) ng/mL 0.09ng/mL Sandwich E-EL-R0614 Rat RETN (Resistin) ng/mL 0.19ng/mL Sandwich E-EL-R0633 Rat MCP-1 (Monocyte Chemotactic Protein 1) ng/mL 0.09ng/mL Sandwich E-EL-R0662 E-EL-R0713 Rat NGAL (Neutrophil Gelatinase Associated Lipocalin) Rat Smad3 (Mothers Against Decapentaplegic Homolog 3) pg/mL 37.5pg/mL Sandwich ng/mL 0.09ng/mL Sandwich E-EL-R0834 Rat PDHA (Pyruvate Dehydrogenase Alpha) ng/mL 0.47ng/mL Sandwich 10 Focus on Lab Research Service for Life Science

12 E-EL-R0835 Rat PDK4 (Pyruvate Dehydrogenase Kinase Isozyme 4) ng/mL 0.09ng/mL Sandwich E-EL-R0881 Rat SAA (Serum Amyloid A) μg/mL 0.09μg/mL Sandwich E-EL-R0911 Rat FLT1/VEGFR1 (Vascular Endothelial Growth Factor Receptor 1) ng/mL 0.09ng/mL Sandwich E-EL-R0976 Rat TSH (Thyroid Stimulating Hormone) ng/mL 0.75ng/mL Sandwich E-EL-R0996 Rat SDC1 (Syndecan 1) ng/mL 0.94ng/mL Sandwich E-EL-R1080 Rat XIAP (X-Linked Inhibitor Of Apoptosis Protein) pg/mL 5.88pg/mL Sandwich E-EL-R1095 Rat LEPR (Leptin Receptor) pg/mL 18.75pg/mL Sandwich E-EL-R1213 Rat ND1 (NADH Dehydrogenase 1) nmol/mL 0.09nmol/mL Sandwich E-EL-R1215 Rat ApoA2 (Apolipoprotein A2) ng/mL 3.75ng/mL Sandwich E-EL-R1218 Rat ApoB (Apolipoprotein B) ng/mL 18.75ng/mL Sandwich E-EL-R1425 Rat SOD2 (Superoxide Dismutase 2, Mitochondrial) ng/mL 0.19ng/mL Competitive E-EL-R2388 Rat 5-HETE (5-Hydroxyeicosatetraenoic Acid) pg/mL 18.75pg/mL Competitive E-EL-R2401 Rat ACE (Angiotensin I Converting Enzyme) ng/mL 0.19ng/mL Sandwich Focus on Lab Research Service for Life Science 11

13 E-EL-R2403 Rat NNE (Non-Neuronal Enolase) ng/mL 0.19ng/mL Sandwich E-EL-R2420 Rat α1-at (Alpha 1-Antitrypsin) ng/mL 3.75ng/mL Sandwich E-EL-R2427 Rat SOST (Sclerostin) pg/mL 9.38pg/mL Sandwich E-EL-R2492 Rat CHEM(Chemerin) pg/mL 18.75pg/mL Sandwich E-EL-R2548 Rat LDHB(Lactate Dehydrogenase B) ng/mL 0.47ng/mL Sandwich 12 Focus on Lab Research Service for Life Science

14 Types of Disease Cat. No Product Name Detection Range Sensitivity E-EL-H0043 Human CRP (C-Reactive Protein) ng/mL 0.47ng/mL Sandwich E-EL-H0058 Human DPP4 (Dipeptidyl Peptidase IV) ng/mL 0.19ng/mL Sandwich E-EL-H0121 Human C-P (C-Peptide) ng/mL 0.09ng/mL Sandwich E-EL-H0250 Human ACO-2 (Aconitase 2) ng/mL 0.19ng/mL Sandwich E-EL-H0930 Human SHH (Hedgehog Homolog, Sonic) pg/mL 46.88pg/mL Sandwich E-EL-H1655 Human mtor (Mammalian Target of Rapamycin) ng/mL 0.09ng/mL Sandwich E-EL-H1818 Human GCK (Glucokinase) ng/mL 0.47ng/mL Sandwich E-EL-H2193 Human FG (Fibrinogen) ng/mL 5.63ng/mL Sandwich E-EL-M0053 Mouse CRP (C-Reactive Protein) ng/mL 0.23ng/mL Sandwich E-EL-M0354 Mouse C-P (C-Peptide) ng/mL 0.09ng/mL Sandwich E-EL-M0390 Mouse CYSLTR2 (Cysteinyl Leukotriene Receptor 2) ng/mL 0.06ng/mL Sandwich Focus on Lab Research Service for Life Science 13

15 E-EL-M0559 Mouse GCK (Glucokinase) ng/mL 0.09ng/mL Sandwich E-EL-R0022 Rat CRP (C-Reactive Protein) ng/mL 0.19ng/mL Sandwich E-EL-R0032 Rat C-P (C-peptide) ng/mL 0.28ng/mL Sandwich E-EL-R0337 Rat DPP Ⅳ (Dipeptidyl Peptldase Ⅳ ) ng/mL 0.38ng/mL Sandwich E-EL-R0426 Rat GCK (Glucokinase) ng/mL 0.38ng/mL Sandwich E-EL-R0582 Rat LEP (Leptin) ng/mL 0.09ng/mL Sandwich E-EL-R0645 Rat PTEN (Phosphatase and Tensin Homolog) ng/mL 0.09ng/mL Sandwich E-EL-R1125 Rat FG (Fibrinogen) ng/mL 37.5ng/mL Sandwich 14 Focus on Lab Research Service for Life Science

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17 Brochure of ELISA kits & Antibodies 16 Focus on Lab Research Service for Life Science

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